DegronMD

Uniprot ID: Q15319

Source protein: POU domain, class 4, transcription factor 3

Source gene: POU4F3

Class: DEG_SPOP_SBC_1

Location: 87:91

E3 ligase: SPOP

DEGRON score: 0.9732

ASA_SCORE: 61.02

COIL: 0.922

CONS_SCORE: 0.4042

DSS_SCORE: 0.4245

HELIX: 0.0494

FCONS_SCORE: 0.8259

RIG_SCORE: 0.6712

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S98P	TCGA-A5-A0G1	UCEC	TCGA	PCTST	DEG_SPOP_SBC_1	0.1389
p.S98P	DO42472	UCEC	ICGC	PCTST	DEG_SPOP_SBC_1	0.1389
p.P96S	TCGA-AM-5821	COAD	TCGA	PCTST	DEG_SPOP_SBC_1	0.1944
p.P96S	DO8240	COAD	ICGC	PCTST	DEG_SPOP_SBC_1	0.1944
p.A78T	TCGA-EI-6917	READ	TCGA	PCTST	DEG_SPOP_SBC_1	0.0833
p.A78T	DO222946	BTCA	ICGC	PCTST	DEG_SPOP_SBC_1	0.0833
p.A78T	DO36881	READ	ICGC	PCTST	DEG_SPOP_SBC_1	0.0833
p.A78T	SIDM00429	B-Lymphoblastic Leukemia	GDSC	PCTST	DEG_SPOP_SBC_1	0.0833
p.A78T	ACH-000938	Leukemia	CCLE	PCTST	DEG_SPOP_SBC_1	0.0833
p.A78T	NALM-6	haematopoietic_and_lymphoid_tissue	COSMIC	PCTST	DEG_SPOP_SBC_1	0.0833
p.S92L	TCGA-EK-A2RK	CESC	TCGA	PCTST	DEG_SPOP_SBC_1	0.3056
p.S92L	DO49952	CESC	ICGC	PCTST	DEG_SPOP_SBC_1	0.3056
p.S92L	DO227981	COCA	ICGC	PCTST	DEG_SPOP_SBC_1	0.3056
p.S92L	DO50679	ORCA	ICGC	PCTST	DEG_SPOP_SBC_1	0.3056
p.S92L	DO218906	SKCA	ICGC	PCTST	DEG_SPOP_SBC_1	0.3056
p.S84C	TCGA-VQ-A8P3	STAD	TCGA	PCTST	DEG_SPOP_SBC_1	0.25
p.S84C	DO51762	STAD	ICGC	PCTST	DEG_SPOP_SBC_1	0.25
p.S93Y	TCGA-VS-A9UL	CESC	TCGA	PCTST	DEG_SPOP_SBC_1	0.2778
p.S93Y	DO51643	CESC	ICGC	PCTST	DEG_SPOP_SBC_1	0.2778
p.T82N	TCGA-XE-AAOC	TGCT	TCGA	PCTST	DEG_SPOP_SBC_1	0.1944
p.S85N	SIDM00781	Colorectal Carcinoma	GDSC	PCTST	DEG_SPOP_SBC_1	0.2778
p.S85N	SIDM00780	Colorectal Carcinoma	GDSC	PCTST	DEG_SPOP_SBC_1	0.2778
p.S85N	ACH-000967	Colon/Colorectal Cancer	CCLE	PCTST	DEG_SPOP_SBC_1	0.2778
p.S85N	ACH-001199	Colon/Colorectal Cancer	CCLE	PCTST	DEG_SPOP_SBC_1	0.2778
p.S85N	SNU-C2B	large_intestine	COSMIC	PCTST	DEG_SPOP_SBC_1	0.2778
p.V95M	SIDM00660	Colorectal Carcinoma	GDSC	PCTST	DEG_SPOP_SBC_1	0.2222
p.V95M	ACH-000985	Colon/Colorectal Cancer	CCLE	PCTST	DEG_SPOP_SBC_1	0.2222
p.V95M	ACH-001329	Brain Cancer	CCLE	PCTST	DEG_SPOP_SBC_1	0.2222
p.V95M	LS-411N	large_intestine	COSMIC	PCTST	DEG_SPOP_SBC_1	0.2222
p.M83I	SIDM01088	Endometrial Carcinoma	GDSC	PCTST	DEG_SPOP_SBC_1	0.2222
p.M83I	ACH-000965	Endometrial/Uterine Cancer	CCLE	PCTST	DEG_SPOP_SBC_1	0.2222
p.M83I	RL95-2	endometrium	COSMIC	PCTST	DEG_SPOP_SBC_1	0.2222
p.S84N	ACH-001991	Primary	CCLE	PCTST	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14917	Protocadherin-17	DEG_SPOP_SBC_1	1046:1050	PCTST	SPOP	0.9985	More...
Q01851	POU domain, class 4, transcription factor 1	DEG_SPOP_SBC_1	89:93	PCTST	SPOP	0.8746	More...
Q12816	Trophinin	DEG_SPOP_SBC_1	923:927	PCTST	SPOP	0.7275	More...
Q15319	POU domain, class 4, transcription factor 3	DEG_SPOP_SBC_1	87:91	PCTST	SPOP	0.9732	More...
Q6ZN17	Protein lin-28 homolog B	DEG_SPOP_SBC_1	186:190	PCTST	SPOP	0.9507	More...
Q8IUM7	Neuronal PAS domain-containing protein 4	DEG_SPOP_SBC_1	503:507	PCTST	SPOP	0.8959	More...
Q8WW38	Zinc finger protein ZFPM2	DEG_SPOP_SBC_1	769:773	PCTST	SPOP	0.5014	More...
Q9Y2X3	Nucleolar protein 58	DEG_SPOP_SBC_1	506:510	PCTST	SPOP	0.9963	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PCTST

Degron related mutations and impact score

Drug responses associated with POU4F3 mutations

All proteins holding degron of PCTST