DegronMD

Uniprot ID: Q9Y2X3

Source protein: Nucleolar protein 58

Source gene: NOP58

Class: DEG_SPOP_SBC_1

Location: 506:510

E3 ligase: SPOP

DEGRON score: 0.9963

ASA_SCORE: 79.96

COIL: 0.8758

CONS_SCORE: 0.3359

DSS_SCORE: 0.5849

HELIX: 0.077

FCONS_SCORE: 0.8528

RIG_SCORE: 0.6782

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K519M	TCGA-04-1353	OV	TCGA	PCTST	DEG_SPOP_SBC_1	0.1944
p.K519M	DO224034	OV	ICGC	PCTST	DEG_SPOP_SBC_1	0.1944
p.T508A	TCGA-A5-A0GP	UCEC	TCGA	PCTST	DEG_SPOP_SBC_1	0.825
p.T508A	DO41109	UCEC	ICGC	PCTST	DEG_SPOP_SBC_1	0.825
p.A511T	TCGA-CM-5861	COAD	TCGA	PCTST	DEG_SPOP_SBC_1	0.3056
p.A511T	TCGA-SL-A6JA	UCEC	TCGA	PCTST	DEG_SPOP_SBC_1	0.3056
p.A511T	DO7918	COAD	ICGC	PCTST	DEG_SPOP_SBC_1	0.3056
p.A511T	DO219787	UCEC	ICGC	PCTST	DEG_SPOP_SBC_1	0.3056
p.K520R	TCGA-DQ-5630	HNSC	TCGA	PCTST	DEG_SPOP_SBC_1	0.1667
p.K520R	DO14486	HNSC	ICGC	PCTST	DEG_SPOP_SBC_1	0.1667
p.S509I	DO229027	LICA	ICGC	PCTST	DEG_SPOP_SBC_1	0.8453
p.P506S	DO231026	LUSC	ICGC	PCTST	DEG_SPOP_SBC_1	0.6752
p.A511E	DO229234	THCA	ICGC	PCTST	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14917	Protocadherin-17	DEG_SPOP_SBC_1	1046:1050	PCTST	SPOP	0.9985	More...
Q01851	POU domain, class 4, transcription factor 1	DEG_SPOP_SBC_1	89:93	PCTST	SPOP	0.8746	More...
Q12816	Trophinin	DEG_SPOP_SBC_1	923:927	PCTST	SPOP	0.7275	More...
Q15319	POU domain, class 4, transcription factor 3	DEG_SPOP_SBC_1	87:91	PCTST	SPOP	0.9732	More...
Q6ZN17	Protein lin-28 homolog B	DEG_SPOP_SBC_1	186:190	PCTST	SPOP	0.9507	More...
Q8IUM7	Neuronal PAS domain-containing protein 4	DEG_SPOP_SBC_1	503:507	PCTST	SPOP	0.8959	More...
Q8WW38	Zinc finger protein ZFPM2	DEG_SPOP_SBC_1	769:773	PCTST	SPOP	0.5014	More...
Q9Y2X3	Nucleolar protein 58	DEG_SPOP_SBC_1	506:510	PCTST	SPOP	0.9963	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons