DegronMD

Uniprot ID: Q01851

Source protein: POU domain, class 4, transcription factor 1

Source gene: POU4F1

Class: DEG_SPOP_SBC_1

Location: 89:93

E3 ligase: SPOP

DEGRON score: 0.8746

ASA_SCORE: 85

COIL: 0.9374

CONS_SCORE: 0.5097

DSS_SCORE: 0.4347

HELIX: 0.0388

FCONS_SCORE: 1.2349

RIG_SCORE: 0.6565

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N86D	TCGA-33-4583	LUSC	TCGA	PCTST	DEG_SPOP_SBC_1	0.25
p.N86D	DO27112	LUSC	ICGC	PCTST	DEG_SPOP_SBC_1	0.25
p.H83Q	TCGA-BR-6565	STAD	TCGA	PCTST	DEG_SPOP_SBC_1	0.1667
p.H83Q	DO38843	STAD	ICGC	PCTST	DEG_SPOP_SBC_1	0.1667
p.D79V	TCGA-DI-A1BU	UCEC	TCGA	PCTST	DEG_SPOP_SBC_1	0.0556
p.D79V	DO42023	UCEC	ICGC	PCTST	DEG_SPOP_SBC_1	0.0556
p.T84M	DO10841	ESAD	ICGC	PCTST	DEG_SPOP_SBC_1	0.1944
p.H102Y	DO27811	MALY	ICGC	PCTST	DEG_SPOP_SBC_1	0.0833
p.C90F	DO37259	READ	ICGC	PCTST	DEG_SPOP_SBC_1	0.5996
p.P89R	SIDM00211	B-Lymphoblastic Leukemia	GDSC	PCTST	DEG_SPOP_SBC_1	0.7512
p.P89R	ACH-002209	Leukemia	CCLE	PCTST	DEG_SPOP_SBC_1	0.7512
p.P89R	ALL-PO	haematopoietic_and_lymphoid_tissue	COSMIC	PCTST	DEG_SPOP_SBC_1	0.7512
p.D79E	SIDM00719	Small Cell Lung Carcinoma	GDSC	PCTST	DEG_SPOP_SBC_1	0.0556
p.D79E	ACH-001364	Lung Cancer	CCLE	PCTST	DEG_SPOP_SBC_1	0.0556
p.D79E	NCI-H345	lung	COSMIC	PCTST	DEG_SPOP_SBC_1	0.0556
p.Y82H	SIDM00537	Colorectal Carcinoma	GDSC	PCTST	DEG_SPOP_SBC_1	0.1389
p.Y82H	ACH-000982	Colon/Colorectal Cancer	CCLE	PCTST	DEG_SPOP_SBC_1	0.1389
p.Y82H	ACH-001345	Colon/Colorectal Cancer	CCLE	PCTST	DEG_SPOP_SBC_1	0.1389
p.Y82H	GP5d	large_intestine	COSMIC	PCTST	DEG_SPOP_SBC_1	0.1389
p.T95A	SIDM00982	Glioblastoma	GDSC	PCTST	DEG_SPOP_SBC_1	0.2778
p.T95A	SIDM01760	Rhabdomyosarcoma	GDSC	PCTST	DEG_SPOP_SBC_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14917	Protocadherin-17	DEG_SPOP_SBC_1	1046:1050	PCTST	SPOP	0.9985	More...
Q01851	POU domain, class 4, transcription factor 1	DEG_SPOP_SBC_1	89:93	PCTST	SPOP	0.8746	More...
Q12816	Trophinin	DEG_SPOP_SBC_1	923:927	PCTST	SPOP	0.7275	More...
Q15319	POU domain, class 4, transcription factor 3	DEG_SPOP_SBC_1	87:91	PCTST	SPOP	0.9732	More...
Q6ZN17	Protein lin-28 homolog B	DEG_SPOP_SBC_1	186:190	PCTST	SPOP	0.9507	More...
Q8IUM7	Neuronal PAS domain-containing protein 4	DEG_SPOP_SBC_1	503:507	PCTST	SPOP	0.8959	More...
Q8WW38	Zinc finger protein ZFPM2	DEG_SPOP_SBC_1	769:773	PCTST	SPOP	0.5014	More...
Q9Y2X3	Nucleolar protein 58	DEG_SPOP_SBC_1	506:510	PCTST	SPOP	0.9963	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons