DegronMD - Q01851(POU4F1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.N86D	TCGA-33-4583	LUSC	TCGA	PCTST	DEG_SPOP_SBC_1	89:93	Mutation rewiring degron network	0.25
p.N86D	DO27112	LUSC	ICGC	PCTST	DEG_SPOP_SBC_1	89:93	Mutation rewiring degron network	0.25
p.H83Q	TCGA-BR-6565	STAD	TCGA	PCTST	DEG_SPOP_SBC_1	89:93	Mutation rewiring degron network	0.1667
p.H83Q	DO38843	STAD	ICGC	PCTST	DEG_SPOP_SBC_1	89:93	Mutation rewiring degron network	0.1667
p.D79V	TCGA-DI-A1BU	UCEC	TCGA	PCTST	DEG_SPOP_SBC_1	89:93	Mutation rewiring degron network	0.0556
p.D79V	DO42023	UCEC	ICGC	PCTST	DEG_SPOP_SBC_1	89:93	Mutation rewiring degron network	0.0556
p.T84M	DO10841	ESAD	ICGC	PCTST	DEG_SPOP_SBC_1	89:93	Mutation rewiring degron network	0.1944
p.H102Y	DO27811	MALY	ICGC	PCTST	DEG_SPOP_SBC_1	89:93	Mutation rewiring degron network	0.0833
p.C90F	DO37259	READ	ICGC	PCTST	DEG_SPOP_SBC_1	89:93	Mutation altering degron motif	0.5996
p.P89R	SIDM00211	B-Lymphoblastic Leukemia	GDSC	PCTST	DEG_SPOP_SBC_1	89:93	Mutation altering degron motif	0.7512
p.P89R	ACH-002209	Leukemia	CCLE	PCTST	DEG_SPOP_SBC_1	89:93	Mutation altering degron motif	0.7512
p.P89R	ALL-PO	haematopoietic and lymphoid tissue	COSMIC	PCTST	DEG_SPOP_SBC_1	89:93	Mutation altering degron motif	0.7512
p.D79E	SIDM00719	Small Cell Lung Carcinoma	GDSC	PCTST	DEG_SPOP_SBC_1	89:93	Mutation rewiring degron network	0.0556
p.D79E	ACH-001364	Lung Cancer	CCLE	PCTST	DEG_SPOP_SBC_1	89:93	Mutation rewiring degron network	0.0556
p.D79E	NCI-H345	lung	COSMIC	PCTST	DEG_SPOP_SBC_1	89:93	Mutation rewiring degron network	0.0556
p.Y82H	SIDM00537	Colorectal Carcinoma	GDSC	PCTST	DEG_SPOP_SBC_1	89:93	Mutation rewiring degron network	0.1389
p.Y82H	ACH-000982	Colon/Colorectal Cancer	CCLE	PCTST	DEG_SPOP_SBC_1	89:93	Mutation rewiring degron network	0.1389
p.Y82H	ACH-001345	Colon/Colorectal Cancer	CCLE	PCTST	DEG_SPOP_SBC_1	89:93	Mutation rewiring degron network	0.1389
p.Y82H	GP5d	large intestine	COSMIC	PCTST	DEG_SPOP_SBC_1	89:93	Mutation rewiring degron network	0.1389
p.T95A	SIDM00982	Glioblastoma	GDSC	PCTST	DEG_SPOP_SBC_1	89:93	Mutation rewiring degron network	0.2778
p.T95A	SIDM01760	Rhabdomyosarcoma	GDSC	PCTST	DEG_SPOP_SBC_1	89:93	Mutation rewiring degron network	0.2778

Kaplan plot for POU4F1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

POU4F1

UniProt ID: Q01851

Entrez ID: 5457

Protein name: POU domain, class 4, transcription factor 1 (Brain-specific homeobox/POU domain protein 3A) (Brain-3A) (Brn-3A) (Homeobox/POU domain protein RDC-1) (Oct-T1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for POU4F1 in