DegronMD - O14917(PCDH17)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S1053F	TCGA-17-Z042	LUAD	TCGA	PCTST	DEG_SPOP_SBC_1	1046:1050	Mutation rewiring degron network	0.25
p.D654Y	TCGA-17-Z059	LUAD	TCGA	DPSSGE	DEG_Kelch_Keap1_1	639:644	Mutation rewiring degron network	0.0556
p.S886I	TCGA-44-A4SS	LUAD	TCGA	DSGHGDS	DEG_SCF_TRCP1_1	889:895	Mutation rewiring degron network	0.25
p.S886I	TCGA-44-A4SS	LUAD	TCGA	VQSSS	DEG_SPOP_SBC_1	873:877	Mutation rewiring degron network	0.0833
p.S886I	TCGA-95-7567	LUAD	TCGA	DSGHGDS	DEG_SCF_TRCP1_1	889:895	Mutation rewiring degron network	0.25
p.S886I	TCGA-95-7567	LUAD	TCGA	VQSSS	DEG_SPOP_SBC_1	873:877	Mutation rewiring degron network	0.0833
p.S886I	DO229028	LICA	ICGC	DSGHGDS	DEG_SCF_TRCP1_1	889:895	Mutation rewiring degron network	0.25
p.S886I	DO229028	LICA	ICGC	VQSSS	DEG_SPOP_SBC_1	873:877	Mutation rewiring degron network	0.0833
p.S886I	DO24227	LUAD	ICGC	DSGHGDS	DEG_SCF_TRCP1_1	889:895	Mutation rewiring degron network	0.25
p.S886I	DO24227	LUAD	ICGC	VQSSS	DEG_SPOP_SBC_1	873:877	Mutation rewiring degron network	0.0833
p.S886I	DO25564	LUAD	ICGC	DSGHGDS	DEG_SCF_TRCP1_1	889:895	Mutation rewiring degron network	0.25
p.S886I	DO25564	LUAD	ICGC	VQSSS	DEG_SPOP_SBC_1	873:877	Mutation rewiring degron network	0.0833
p.F879L	TCGA-50-6593	LUAD	TCGA	DSGHGDS	DEG_SCF_TRCP1_1	889:895	Mutation rewiring degron network	0.0556
p.F879L	TCGA-50-6593	LUAD	TCGA	VQSSS	DEG_SPOP_SBC_1	873:877	Mutation rewiring degron network	0.2778
p.F879L	DO24100	LUAD	ICGC	DSGHGDS	DEG_SCF_TRCP1_1	889:895	Mutation rewiring degron network	0.0556
p.F879L	DO24100	LUAD	ICGC	VQSSS	DEG_SPOP_SBC_1	873:877	Mutation rewiring degron network	0.2778
p.G867C	TCGA-55-6978	LUAD	TCGA	VQSSS	DEG_SPOP_SBC_1	873:877	Mutation rewiring degron network	0.1667
p.G867C	DO23625	LUAD	ICGC	VQSSS	DEG_SPOP_SBC_1	873:877	Mutation rewiring degron network	0.1667
p.E653A	TCGA-5M-AAT6	COAD	TCGA	DPSSGE	DEG_Kelch_Keap1_1	639:644	Mutation rewiring degron network	0.0833
p.E653A	DO223703	COAD	ICGC	DPSSGE	DEG_Kelch_Keap1_1	639:644	Mutation rewiring degron network	0.0833
p.I645V	TCGA-61-2096	OV	TCGA	DPSSGE	DEG_Kelch_Keap1_1	639:644	Mutation rewiring degron network	0.3056
p.I645V	DO29708	OV	ICGC	DPSSGE	DEG_Kelch_Keap1_1	639:644	Mutation rewiring degron network	0.3056
p.Q874E	TCGA-63-A5MW	LUSC	TCGA	VQSSS	DEG_SPOP_SBC_1	873:877	Mutation altering degron motif	0.5633
p.Q874E	DO219169	LUSC	ICGC	VQSSS	DEG_SPOP_SBC_1	873:877	Mutation altering degron motif	0.5633
p.A1042E	TCGA-73-4666	LUAD	TCGA	PCTST	DEG_SPOP_SBC_1	1046:1050	Mutation rewiring degron network	0.2222
p.A1042E	DO26230	LUAD	ICGC	PCTST	DEG_SPOP_SBC_1	1046:1050	Mutation rewiring degron network	0.2222
p.R646S	TCGA-AA-3663	COAD	TCGA	DPSSGE	DEG_Kelch_Keap1_1	639:644	Mutation rewiring degron network	0.2778
p.R646S	DO9346	COAD	ICGC	DPSSGE	DEG_Kelch_Keap1_1	639:644	Mutation rewiring degron network	0.2778
p.G893V	TCGA-AD-6548	COAD	TCGA	DSGHGDS	DEG_SCF_TRCP1_1	889:895	Mutation altering degron motif	0.6421
p.G893V	DO9586	COAD	ICGC	DSGHGDS	DEG_SCF_TRCP1_1	889:895	Mutation altering degron motif	0.6421
p.D639N	TCGA-AP-A059	UCEC	TCGA	DPSSGE	DEG_Kelch_Keap1_1	639:644	Mutation altering degron motif	0.5821
p.D639N	DO41361	UCEC	ICGC	DPSSGE	DEG_Kelch_Keap1_1	639:644	Mutation altering degron motif	0.5821
p.C1043Y	TCGA-AP-A0LM	UCEC	TCGA	PCTST	DEG_SPOP_SBC_1	1046:1050	Mutation rewiring degron network	0.25
p.C1043Y	DO43306	UCEC	ICGC	PCTST	DEG_SPOP_SBC_1	1046:1050	Mutation rewiring degron network	0.25
p.D903G	TCGA-AX-A06F	UCEC	TCGA	DSGHGDS	DEG_SCF_TRCP1_1	889:895	Mutation rewiring degron network	0.1111
p.D903G	DO41752	UCEC	ICGC	DSGHGDS	DEG_SCF_TRCP1_1	889:895	Mutation rewiring degron network	0.1111
p.R888I	TCGA-AX-A2HC	UCEC	TCGA	DSGHGDS	DEG_SCF_TRCP1_1	889:895	Mutation rewiring degron network	0.3056
p.R888I	DO41572	UCEC	ICGC	DSGHGDS	DEG_SCF_TRCP1_1	889:895	Mutation rewiring degron network	0.3056
p.H634R	TCGA-BG-A222	UCEC	TCGA	DPSSGE	DEG_Kelch_Keap1_1	639:644	Mutation rewiring degron network	0.1944
p.H634R	DO42977	UCEC	ICGC	DPSSGE	DEG_Kelch_Keap1_1	639:644	Mutation rewiring degron network	0.1944
p.Q870P	TCGA-BH-A0BZ	BRCA	TCGA	VQSSS	DEG_SPOP_SBC_1	873:877	Mutation rewiring degron network	0.25
p.Q870P	DO1396	BRCA	ICGC	VQSSS	DEG_SPOP_SBC_1	873:877	Mutation rewiring degron network	0.25
p.R646H	TCGA-BR-7851	STAD	TCGA	DPSSGE	DEG_Kelch_Keap1_1	639:644	Mutation rewiring degron network	0.2778
p.R646H	DO38711	STAD	ICGC	DPSSGE	DEG_Kelch_Keap1_1	639:644	Mutation rewiring degron network	0.2778
p.S1037R	TCGA-CG-4436	STAD	TCGA	PCTST	DEG_SPOP_SBC_1	1046:1050	Mutation blocking phosphorylation signal	0.5278
p.S1037R	DO38320	STAD	ICGC	PCTST	DEG_SPOP_SBC_1	1046:1050	Mutation blocking phosphorylation signal	0.5278
p.S1037C	TCGA-CK-4952	COAD	TCGA	PCTST	DEG_SPOP_SBC_1	1046:1050	Mutation blocking phosphorylation signal	0.5278
p.S1037C	DO10357	COAD	ICGC	PCTST	DEG_SPOP_SBC_1	1046:1050	Mutation blocking phosphorylation signal	0.5278
p.E644D	TCGA-CV-6961	HNSC	TCGA	DPSSGE	DEG_Kelch_Keap1_1	639:644	Mutation altering degron motif	0.6758
p.E644D	DO14566	HNSC	ICGC	DPSSGE	DEG_Kelch_Keap1_1	639:644	Mutation altering degron motif	0.6758
p.K1051N	TCGA-CV-A45Z	HNSC	TCGA	PCTST	DEG_SPOP_SBC_1	1046:1050	Mutation rewiring degron network	0.3056
p.K1051N	DO52064	HNSC	ICGC	PCTST	DEG_SPOP_SBC_1	1046:1050	Mutation rewiring degron network	0.3056
p.S900R	TCGA-D3-A2JF	SKCM	TCGA	DSGHGDS	DEG_SCF_TRCP1_1	889:895	Mutation rewiring degron network	0.1944
p.S900R	DO38153	SKCM	ICGC	DSGHGDS	DEG_SCF_TRCP1_1	889:895	Mutation rewiring degron network	0.1944
p.D903H	TCGA-D3-A3MR	SKCM	TCGA	DSGHGDS	DEG_SCF_TRCP1_1	889:895	Mutation rewiring degron network	0.1111
p.D903H	DO47256	SKCM	ICGC	DSGHGDS	DEG_SCF_TRCP1_1	889:895	Mutation rewiring degron network	0.1111
p.D881N	TCGA-D3-A5GN	SKCM	TCGA	DSGHGDS	DEG_SCF_TRCP1_1	889:895	Mutation rewiring degron network	0.1111
p.D881N	TCGA-D3-A5GN	SKCM	TCGA	VQSSS	DEG_SPOP_SBC_1	873:877	Mutation rewiring degron network	0.2222
p.D881N	DO47317	SKCM	ICGC	DSGHGDS	DEG_SCF_TRCP1_1	889:895	Mutation rewiring degron network	0.1111
p.D881N	DO47317	SKCM	ICGC	VQSSS	DEG_SPOP_SBC_1	873:877	Mutation rewiring degron network	0.2222
p.K1060N	TCGA-D5-6928	COAD	TCGA	PCTST	DEG_SPOP_SBC_1	1046:1050	Mutation substituting flanking lysine	0.1667
p.K1060N	DO7776	COAD	ICGC	PCTST	DEG_SPOP_SBC_1	1046:1050	Mutation substituting flanking lysine	0.1667
p.K1060N	DO50438	ESAD	ICGC	PCTST	DEG_SPOP_SBC_1	1046:1050	Mutation substituting flanking lysine	0.1667
p.E637Q	TCGA-D6-8569	HNSC	TCGA	DPSSGE	DEG_Kelch_Keap1_1	639:644	Mutation rewiring degron network	0.2778
p.E637Q	DO14454	HNSC	ICGC	DPSSGE	DEG_Kelch_Keap1_1	639:644	Mutation rewiring degron network	0.2778
p.T1040P	TCGA-DM-A28F	COAD	TCGA	PCTST	DEG_SPOP_SBC_1	1046:1050	Mutation blocking phosphorylation signal	0.6111
p.T1040P	DO9828	COAD	ICGC	PCTST	DEG_SPOP_SBC_1	1046:1050	Mutation blocking phosphorylation signal	0.6111
p.T1040P	DO233703	GACA	ICGC	PCTST	DEG_SPOP_SBC_1	1046:1050	Mutation blocking phosphorylation signal	0.6111
p.P650S	TCGA-EE-A2GB	SKCM	TCGA	DPSSGE	DEG_Kelch_Keap1_1	639:644	Mutation rewiring degron network	0.1667
p.P650S	DO222683	MELA	ICGC	DPSSGE	DEG_Kelch_Keap1_1	639:644	Mutation rewiring degron network	0.1667
p.P650S	DO37417	SKCM	ICGC	DPSSGE	DEG_Kelch_Keap1_1	639:644	Mutation rewiring degron network	0.1667
p.E1045K	TCGA-EO-A22U	UCEC	TCGA	PCTST	DEG_SPOP_SBC_1	1046:1050	Mutation rewiring degron network	0.3056
p.E1045K	DO43755	UCEC	ICGC	PCTST	DEG_SPOP_SBC_1	1046:1050	Mutation rewiring degron network	0.3056
p.A1042V	TCGA-FI-A2D5	UCEC	TCGA	PCTST	DEG_SPOP_SBC_1	1046:1050	Mutation rewiring degron network	0.2222
p.A1042V	DO234161	ESAD	ICGC	PCTST	DEG_SPOP_SBC_1	1046:1050	Mutation rewiring degron network	0.2222
p.A1042V	DO41331	UCEC	ICGC	PCTST	DEG_SPOP_SBC_1	1046:1050	Mutation rewiring degron network	0.2222
p.E1058K	TCGA-GN-A266	SKCM	TCGA	PCTST	DEG_SPOP_SBC_1	1046:1050	Mutation rewiring degron network	0.1111
p.E1058K	DO37432	SKCM	ICGC	PCTST	DEG_SPOP_SBC_1	1046:1050	Mutation rewiring degron network	0.1111
p.E1058K	ACH-002669	Colon/Colorectal Cancer	CCLE	PCTST	DEG_SPOP_SBC_1	1046:1050	Mutation rewiring degron network	0.1111
p.K1060T	TCGA-HU-8604	STAD	TCGA	PCTST	DEG_SPOP_SBC_1	1046:1050	Mutation substituting flanking lysine	0.1667
p.K1060T	DO47907	STAD	ICGC	PCTST	DEG_SPOP_SBC_1	1046:1050	Mutation substituting flanking lysine	0.1667
p.P1039T	TCGA-JY-A6FD	ESCA	TCGA	PCTST	DEG_SPOP_SBC_1	1046:1050	Mutation rewiring degron network	0.1389
p.K1041N	TCGA-NJ-A4YF	LUAD	TCGA	PCTST	DEG_SPOP_SBC_1	1046:1050	Mutation substituting flanking lysine	0.3056
p.K1041N	DO218940	LUAD	ICGC	PCTST	DEG_SPOP_SBC_1	1046:1050	Mutation substituting flanking lysine	0.3056
p.D896Y	TCGA-OR-A5KB	ACC	TCGA	DSGHGDS	DEG_SCF_TRCP1_1	889:895	Mutation rewiring degron network	0.3056
p.D629Y	TCGA-V5-A7RC	ESCA	TCGA	DPSSGE	DEG_Kelch_Keap1_1	639:644	Mutation rewiring degron network	0.0556
p.M866L	TCGA-VQ-A8DU	STAD	TCGA	VQSSS	DEG_SPOP_SBC_1	873:877	Mutation rewiring degron network	0.1389
p.M866L	DO51752	STAD	ICGC	VQSSS	DEG_SPOP_SBC_1	873:877	Mutation rewiring degron network	0.1389
p.N631T	DO50338	ESAD	ICGC	DPSSGE	DEG_Kelch_Keap1_1	639:644	Mutation rewiring degron network	0.1111
p.T1040A	DO233114	GACA	ICGC	PCTST	DEG_SPOP_SBC_1	1046:1050	Mutation blocking phosphorylation signal	0.6111
p.T647M	DO233767	GACA	ICGC	DPSSGE	DEG_Kelch_Keap1_1	639:644	Mutation blocking phosphorylation signal	0.6944
p.T647M	SIDM02035	Colorectal Carcinoma	GDSC	DPSSGE	DEG_Kelch_Keap1_1	639:644	Mutation blocking phosphorylation signal	0.6944
p.D632G	DO233701	GACA	ICGC	DPSSGE	DEG_Kelch_Keap1_1	639:644	Mutation rewiring degron network	0.1389
p.T878M	DO233749	GACA	ICGC	VQSSS	DEG_SPOP_SBC_1	873:877	Mutation rewiring degron network	0.3056
p.T878M	DO228851	MALY	ICGC	VQSSS	DEG_SPOP_SBC_1	873:877	Mutation rewiring degron network	0.3056
p.S886R	DO228359	LICA	ICGC	DSGHGDS	DEG_SCF_TRCP1_1	889:895	Mutation rewiring degron network	0.25
p.S886R	DO228359	LICA	ICGC	VQSSS	DEG_SPOP_SBC_1	873:877	Mutation rewiring degron network	0.0833
p.S895R	DO231947	LICA	ICGC	DSGHGDS	DEG_SCF_TRCP1_1	889:895	Mutation altering degron motif	0.7427
p.G891V	DO228952	LICA	ICGC	DSGHGDS	DEG_SCF_TRCP1_1	889:895	Mutation altering degron motif	0.7532
p.D899Y	DO228976	LICA	ICGC	DSGHGDS	DEG_SCF_TRCP1_1	889:895	Mutation rewiring degron network	0.2222
p.G1056V	DO229041	LICA	ICGC	PCTST	DEG_SPOP_SBC_1	1046:1050	Mutation rewiring degron network	0.1667
p.S876I	DO229045	LICA	ICGC	VQSSS	DEG_SPOP_SBC_1	873:877	Mutation altering degron motif	0.7341
p.G867V	DO229009	LICA	ICGC	VQSSS	DEG_SPOP_SBC_1	873:877	Mutation rewiring degron network	0.1667
p.A885S	DO23544	LIRI	ICGC	DSGHGDS	DEG_SCF_TRCP1_1	889:895	Mutation rewiring degron network	0.2222
p.A885S	DO23544	LIRI	ICGC	VQSSS	DEG_SPOP_SBC_1	873:877	Mutation rewiring degron network	0.1111
p.R884K	DO229177	LMS	ICGC	DSGHGDS	DEG_SCF_TRCP1_1	889:895	Mutation rewiring degron network	0.1944
p.R884K	DO229177	LMS	ICGC	VQSSS	DEG_SPOP_SBC_1	873:877	Mutation rewiring degron network	0.1389
p.T1048I	DO220877	MELA	ICGC	PCTST	DEG_SPOP_SBC_1	1046:1050	Mutation altering degron motif	0.7078
p.T1048I	DO219878	SKCA	ICGC	PCTST	DEG_SPOP_SBC_1	1046:1050	Mutation altering degron motif	0.7078
p.A898G	DO227736	PACA	ICGC	DSGHGDS	DEG_SCF_TRCP1_1	889:895	Mutation rewiring degron network	0.25
p.I645N	DO224719	PACA	ICGC	DPSSGE	DEG_Kelch_Keap1_1	639:644	Mutation rewiring degron network	0.3056
p.P640S	DO219878	SKCA	ICGC	DPSSGE	DEG_Kelch_Keap1_1	639:644	Mutation altering degron motif	0.5641
p.Q897H	SIDM01943	Colorectal Carcinoma	GDSC	DSGHGDS	DEG_SCF_TRCP1_1	889:895	Mutation rewiring degron network	0.2778
p.S642I	SIDM00661	B-Cell Non-Hodgkin's Lymphoma	GDSC	DPSSGE	DEG_Kelch_Keap1_1	639:644	Mutation altering degron motif	0.8453
p.S642I	ACH-000914	Lymphoma	CCLE	DPSSGE	DEG_Kelch_Keap1_1	639:644	Mutation altering degron motif	0.8453
p.S642I	HT	haematopoietic and lymphoid tissue	COSMIC	DPSSGE	DEG_Kelch_Keap1_1	639:644	Mutation altering degron motif	0.8453
p.T1048A	SIDM00845	Burkitt's Lymphoma	GDSC	PCTST	DEG_SPOP_SBC_1	1046:1050	Mutation altering degron motif	0.7139
p.T1048A	Daudi	haematopoietic and lymphoid tissue	COSMIC	PCTST	DEG_SPOP_SBC_1	1046:1050	Mutation altering degron motif	0.7139
p.L887V	SIDM00477	Esophageal Carcinoma	GDSC	DSGHGDS	DEG_SCF_TRCP1_1	889:895	Mutation rewiring degron network	0.2778
p.L887V	SIDM00477	Esophageal Carcinoma	GDSC	VQSSS	DEG_SPOP_SBC_1	873:877	Mutation rewiring degron network	0.0556
p.L887V	ACH-000383	Esophageal Cancer	CCLE	DSGHGDS	DEG_SCF_TRCP1_1	889:895	Mutation rewiring degron network	0.2778
p.L887V	ACH-000383	Esophageal Cancer	CCLE	VQSSS	DEG_SPOP_SBC_1	873:877	Mutation rewiring degron network	0.0556
p.L887V	OE33	oesophagus	COSMIC	DSGHGDS	DEG_SCF_TRCP1_1	889:895	Mutation rewiring degron network	0.2778
p.L887V	OE33	oesophagus	COSMIC	VQSSS	DEG_SPOP_SBC_1	873:877	Mutation rewiring degron network	0.0556
p.R884I	SIDM00892	Breast Carcinoma	GDSC	DSGHGDS	DEG_SCF_TRCP1_1	889:895	Mutation rewiring degron network	0.1944
p.R884I	SIDM00892	Breast Carcinoma	GDSC	VQSSS	DEG_SPOP_SBC_1	873:877	Mutation rewiring degron network	0.1389
p.R884I	ACH-000818	Breast Cancer	CCLE	DSGHGDS	DEG_SCF_TRCP1_1	889:895	Mutation rewiring degron network	0.1944
p.R884I	ACH-000818	Breast Cancer	CCLE	VQSSS	DEG_SPOP_SBC_1	873:877	Mutation rewiring degron network	0.1389
p.R884I	BT-483	breast	COSMIC	DSGHGDS	DEG_SCF_TRCP1_1	889:895	Mutation rewiring degron network	0.1944
p.R884I	BT-483	breast	COSMIC	VQSSS	DEG_SPOP_SBC_1	873:877	Mutation rewiring degron network	0.1389
p.G630D	SIDM00118	Colorectal Carcinoma	GDSC	DPSSGE	DEG_Kelch_Keap1_1	639:644	Mutation rewiring degron network	0.0833
p.G630D	ACH-001081	Colon/Colorectal Cancer	CCLE	DPSSGE	DEG_Kelch_Keap1_1	639:644	Mutation rewiring degron network	0.0833
p.G630D	HCC2998	large intestine	COSMIC	DPSSGE	DEG_Kelch_Keap1_1	639:644	Mutation rewiring degron network	0.0833
p.F872L	SIDM00016	Neuroblastoma	GDSC	VQSSS	DEG_SPOP_SBC_1	873:877	Mutation rewiring degron network	0.3056
p.F872L	ACH-000446	Neuroblastoma	CCLE	VQSSS	DEG_SPOP_SBC_1	873:877	Mutation rewiring degron network	0.3056
p.P1039L	ACH-001567	Skin Cancer	CCLE	PCTST	DEG_SPOP_SBC_1	1046:1050	Mutation rewiring degron network	0.1389
p.E637D	ACH-001656	Leukemia	CCLE	DPSSGE	DEG_Kelch_Keap1_1	639:644	Mutation rewiring degron network	0.2778
p.L648P	ACH-001786	Colon/Colorectal Cancer	CCLE	DPSSGE	DEG_Kelch_Keap1_1	639:644	Mutation rewiring degron network	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PCDH17

UniProt ID: O14917

Entrez ID: 27253

Protein name: Protocadherin-17 (Protocadherin-68)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PCDH17 in