DegronMD

Uniprot ID: O14917

Source protein: Protocadherin-17

Source gene: PCDH17

Class: DEG_SPOP_SBC_1

Location: 1046:1050

E3 ligase: SPOP

DEGRON score: 0.9985

ASA_SCORE: 66.3

COIL: 0.8502

CONS_SCORE: 0.5069

DSS_SCORE: 0.3334

HELIX: 0.0504

FCONS_SCORE: 1.0442

RIG_SCORE: 0.7148

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1053F	TCGA-17-Z042	LUAD	TCGA	PCTST	DEG_SPOP_SBC_1	0.25
p.A1042E	TCGA-73-4666	LUAD	TCGA	PCTST	DEG_SPOP_SBC_1	0.2222
p.A1042E	DO26230	LUAD	ICGC	PCTST	DEG_SPOP_SBC_1	0.2222
p.C1043Y	TCGA-AP-A0LM	UCEC	TCGA	PCTST	DEG_SPOP_SBC_1	0.25
p.C1043Y	DO43306	UCEC	ICGC	PCTST	DEG_SPOP_SBC_1	0.25
p.S1037R	TCGA-CG-4436	STAD	TCGA	PCTST	DEG_SPOP_SBC_1	0.5278
p.S1037R	DO38320	STAD	ICGC	PCTST	DEG_SPOP_SBC_1	0.5278
p.S1037C	TCGA-CK-4952	COAD	TCGA	PCTST	DEG_SPOP_SBC_1	0.5278
p.S1037C	DO10357	COAD	ICGC	PCTST	DEG_SPOP_SBC_1	0.5278
p.K1051N	TCGA-CV-A45Z	HNSC	TCGA	PCTST	DEG_SPOP_SBC_1	0.3056
p.K1051N	DO52064	HNSC	ICGC	PCTST	DEG_SPOP_SBC_1	0.3056
p.K1060N	TCGA-D5-6928	COAD	TCGA	PCTST	DEG_SPOP_SBC_1	0.1667
p.K1060N	DO7776	COAD	ICGC	PCTST	DEG_SPOP_SBC_1	0.1667
p.K1060N	DO50438	ESAD	ICGC	PCTST	DEG_SPOP_SBC_1	0.1667
p.T1040P	TCGA-DM-A28F	COAD	TCGA	PCTST	DEG_SPOP_SBC_1	0.6111
p.T1040P	DO9828	COAD	ICGC	PCTST	DEG_SPOP_SBC_1	0.6111
p.T1040P	DO233703	GACA	ICGC	PCTST	DEG_SPOP_SBC_1	0.6111
p.E1045K	TCGA-EO-A22U	UCEC	TCGA	PCTST	DEG_SPOP_SBC_1	0.3056
p.E1045K	DO43755	UCEC	ICGC	PCTST	DEG_SPOP_SBC_1	0.3056
p.A1042V	TCGA-FI-A2D5	UCEC	TCGA	PCTST	DEG_SPOP_SBC_1	0.2222
p.A1042V	DO234161	ESAD	ICGC	PCTST	DEG_SPOP_SBC_1	0.2222
p.A1042V	DO41331	UCEC	ICGC	PCTST	DEG_SPOP_SBC_1	0.2222
p.E1058K	TCGA-GN-A266	SKCM	TCGA	PCTST	DEG_SPOP_SBC_1	0.1111
p.E1058K	DO37432	SKCM	ICGC	PCTST	DEG_SPOP_SBC_1	0.1111
p.E1058K	ACH-002669	Colon/Colorectal Cancer	CCLE	PCTST	DEG_SPOP_SBC_1	0.1111
p.K1060T	TCGA-HU-8604	STAD	TCGA	PCTST	DEG_SPOP_SBC_1	0.1667
p.K1060T	DO47907	STAD	ICGC	PCTST	DEG_SPOP_SBC_1	0.1667
p.P1039T	TCGA-JY-A6FD	ESCA	TCGA	PCTST	DEG_SPOP_SBC_1	0.1389
p.K1041N	TCGA-NJ-A4YF	LUAD	TCGA	PCTST	DEG_SPOP_SBC_1	0.3056
p.K1041N	DO218940	LUAD	ICGC	PCTST	DEG_SPOP_SBC_1	0.3056
p.T1040A	DO233114	GACA	ICGC	PCTST	DEG_SPOP_SBC_1	0.6111
p.G1056V	DO229041	LICA	ICGC	PCTST	DEG_SPOP_SBC_1	0.1667
p.T1048I	DO220877	MELA	ICGC	PCTST	DEG_SPOP_SBC_1	0.7078
p.T1048I	DO219878	SKCA	ICGC	PCTST	DEG_SPOP_SBC_1	0.7078
p.T1048A	SIDM00845	Burkitt's Lymphoma	GDSC	PCTST	DEG_SPOP_SBC_1	0.7139
p.T1048A	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	PCTST	DEG_SPOP_SBC_1	0.7139
p.P1039L	ACH-001567	Skin Cancer	CCLE	PCTST	DEG_SPOP_SBC_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14917	Protocadherin-17	DEG_SPOP_SBC_1	1046:1050	PCTST	SPOP	0.9985	More...
Q01851	POU domain, class 4, transcription factor 1	DEG_SPOP_SBC_1	89:93	PCTST	SPOP	0.8746	More...
Q12816	Trophinin	DEG_SPOP_SBC_1	923:927	PCTST	SPOP	0.7275	More...
Q15319	POU domain, class 4, transcription factor 3	DEG_SPOP_SBC_1	87:91	PCTST	SPOP	0.9732	More...
Q6ZN17	Protein lin-28 homolog B	DEG_SPOP_SBC_1	186:190	PCTST	SPOP	0.9507	More...
Q8IUM7	Neuronal PAS domain-containing protein 4	DEG_SPOP_SBC_1	503:507	PCTST	SPOP	0.8959	More...
Q8WW38	Zinc finger protein ZFPM2	DEG_SPOP_SBC_1	769:773	PCTST	SPOP	0.5014	More...
Q9Y2X3	Nucleolar protein 58	DEG_SPOP_SBC_1	506:510	PCTST	SPOP	0.9963	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PCTST

Degron related mutations and impact score

Drug responses associated with PCDH17 mutations

All proteins holding degron of PCTST