DegronMD - Q9Y2X3(NOP58)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K519M	TCGA-04-1353	OV	TCGA	PCTST	DEG_SPOP_SBC_1	506:510	Mutation substituting flanking lysine	0.1944
p.K519M	DO224034	OV	ICGC	PCTST	DEG_SPOP_SBC_1	506:510	Mutation substituting flanking lysine	0.1944
p.T508A	TCGA-A5-A0GP	UCEC	TCGA	PCTST	DEG_SPOP_SBC_1	506:510	Mutation altering degron motif	0.825
p.T508A	DO41109	UCEC	ICGC	PCTST	DEG_SPOP_SBC_1	506:510	Mutation altering degron motif	0.825
p.A511T	TCGA-CM-5861	COAD	TCGA	PCTST	DEG_SPOP_SBC_1	506:510	Mutation rewiring degron network	0.3056
p.A511T	TCGA-SL-A6JA	UCEC	TCGA	PCTST	DEG_SPOP_SBC_1	506:510	Mutation rewiring degron network	0.3056
p.A511T	DO7918	COAD	ICGC	PCTST	DEG_SPOP_SBC_1	506:510	Mutation rewiring degron network	0.3056
p.A511T	DO219787	UCEC	ICGC	PCTST	DEG_SPOP_SBC_1	506:510	Mutation rewiring degron network	0.3056
p.K520R	TCGA-DQ-5630	HNSC	TCGA	PCTST	DEG_SPOP_SBC_1	506:510	Mutation substituting flanking lysine	0.1667
p.K520R	DO14486	HNSC	ICGC	PCTST	DEG_SPOP_SBC_1	506:510	Mutation substituting flanking lysine	0.1667
p.S509I	DO229027	LICA	ICGC	PCTST	DEG_SPOP_SBC_1	506:510	Mutation altering degron motif	0.8453
p.P506S	DO231026	LUSC	ICGC	PCTST	DEG_SPOP_SBC_1	506:510	Mutation altering degron motif	0.6752
p.A511E	DO229234	THCA	ICGC	PCTST	DEG_SPOP_SBC_1	506:510	Mutation rewiring degron network	0.3056

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons