DegronMD

Uniprot ID: Q8WW38

Source protein: Zinc finger protein ZFPM2

Source gene: ZFPM2

Class: DEG_SPOP_SBC_1

Location: 769:773

E3 ligase: SPOP

DEGRON score: 0.5014

ASA_SCORE: 71.52

COIL: 0.8408

CONS_SCORE: 0.436

DSS_SCORE: 0.4101

HELIX: 0.0932

FCONS_SCORE: 1.1183

RIG_SCORE: 0.7052

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L761P	TCGA-2H-A9GF	ESCA	TCGA	PCTST	DEG_SPOP_SBC_1	0.1111
p.G779R	TCGA-55-8207	LUAD	TCGA	PCTST	DEG_SPOP_SBC_1	0.1667
p.G779R	DO45351	LUAD	ICGC	PCTST	DEG_SPOP_SBC_1	0.1667
p.P776T	TCGA-61-1913	OV	TCGA	PCTST	DEG_SPOP_SBC_1	0.25
p.P776T	DO32069	OV	ICGC	PCTST	DEG_SPOP_SBC_1	0.25
p.C770S	TCGA-AA-3831	COAD	TCGA	PCTST	DEG_SPOP_SBC_1	0.643
p.C770S	DO8538	COAD	ICGC	PCTST	DEG_SPOP_SBC_1	0.643
p.P776S	TCGA-CA-6717	COAD	TCGA	PCTST	DEG_SPOP_SBC_1	0.25
p.P776S	DO8264	COAD	ICGC	PCTST	DEG_SPOP_SBC_1	0.25
p.P769H	TCGA-EE-A2GR	SKCM	TCGA	PCTST	DEG_SPOP_SBC_1	0.7694
p.P769H	DO37996	SKCM	ICGC	PCTST	DEG_SPOP_SBC_1	0.7694
p.T771I	TCGA-EO-A3AY	UCEC	TCGA	PCTST	DEG_SPOP_SBC_1	0.7078
p.T771I	DO43202	UCEC	ICGC	PCTST	DEG_SPOP_SBC_1	0.7078
p.L780I	TCGA-EO-A3AY	UCEC	TCGA	PCTST	DEG_SPOP_SBC_1	0.1389
p.L780I	DO43202	UCEC	ICGC	PCTST	DEG_SPOP_SBC_1	0.1389
p.P769S	TCGA-FS-A1Z3	SKCM	TCGA	PCTST	DEG_SPOP_SBC_1	0.6752
p.P769S	DO37635	SKCM	ICGC	PCTST	DEG_SPOP_SBC_1	0.6752
p.Q774L	TCGA-L9-A7SV	LUAD	TCGA	PCTST	DEG_SPOP_SBC_1	0.3056
p.Q774L	DO49875	LUAD	ICGC	PCTST	DEG_SPOP_SBC_1	0.3056
p.D762Y	TCGA-NJ-A4YF	LUAD	TCGA	PCTST	DEG_SPOP_SBC_1	0.1389
p.D762Y	DO218940	LUAD	ICGC	PCTST	DEG_SPOP_SBC_1	0.1389
p.G781E	TCGA-YD-A89C	SKCM	TCGA	PCTST	DEG_SPOP_SBC_1	0.1111
p.G781E	DO219501	SKCM	ICGC	PCTST	DEG_SPOP_SBC_1	0.1111
p.N765S	DO222973	BTCA	ICGC	PCTST	DEG_SPOP_SBC_1	0.2222
p.T771A	DO228656	GACA	ICGC	PCTST	DEG_SPOP_SBC_1	0.7139
p.L761R	DO233949	GACA	ICGC	PCTST	DEG_SPOP_SBC_1	0.1111
p.L761I	DO231495	THCA	ICGC	PCTST	DEG_SPOP_SBC_1	0.1111
p.V763I	SIDM00718	Non-Small Cell Lung Carcinoma	GDSC	PCTST	DEG_SPOP_SBC_1	0.1667
p.V763I	SIDM01178	Other Solid Cancers	GDSC	PCTST	DEG_SPOP_SBC_1	0.1667
p.V763I	SIDM01083	Oral Cavity Carcinoma	GDSC	PCTST	DEG_SPOP_SBC_1	0.1667
p.N767S	SIDM00412	B-Cell Non-Hodgkin's Lymphoma	GDSC	PCTST	DEG_SPOP_SBC_1	0.2778
p.N767S	WSU-NHL	haematopoietic_and_lymphoid_tissue	COSMIC	PCTST	DEG_SPOP_SBC_1	0.2778
p.S780N	SNU-1040	large_intestine	COSMIC	PCTST	DEG_SPOP_SBC_1	0.1389
p.K761E	CW-2	large_intestine	COSMIC	PCTST	DEG_SPOP_SBC_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14917	Protocadherin-17	DEG_SPOP_SBC_1	1046:1050	PCTST	SPOP	0.9985	More...
Q01851	POU domain, class 4, transcription factor 1	DEG_SPOP_SBC_1	89:93	PCTST	SPOP	0.8746	More...
Q12816	Trophinin	DEG_SPOP_SBC_1	923:927	PCTST	SPOP	0.7275	More...
Q15319	POU domain, class 4, transcription factor 3	DEG_SPOP_SBC_1	87:91	PCTST	SPOP	0.9732	More...
Q6ZN17	Protein lin-28 homolog B	DEG_SPOP_SBC_1	186:190	PCTST	SPOP	0.9507	More...
Q8IUM7	Neuronal PAS domain-containing protein 4	DEG_SPOP_SBC_1	503:507	PCTST	SPOP	0.8959	More...
Q8WW38	Zinc finger protein ZFPM2	DEG_SPOP_SBC_1	769:773	PCTST	SPOP	0.5014	More...
Q9Y2X3	Nucleolar protein 58	DEG_SPOP_SBC_1	506:510	PCTST	SPOP	0.9963	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PCTST

Degron related mutations and impact score

Drug responses associated with ZFPM2 mutations

All proteins holding degron of PCTST