DegronMD

Uniprot ID: Q12816

Source protein: Trophinin

Source gene: TRO

Class: DEG_SPOP_SBC_1

Location: 923:927

E3 ligase: SPOP

DEGRON score: 0.7275

ASA_SCORE: 80.22

COIL: 0.8984

CONS_SCORE: 0.4116

DSS_SCORE: 0.1725

HELIX: 0.0358

FCONS_SCORE: 0.8046

RIG_SCORE: 0.7377

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G920S	TCGA-A5-A2K5	UCEC	TCGA	PCTST	DEG_SPOP_SBC_1	0.25
p.G920S	DO231673	LINC	ICGC	PCTST	DEG_SPOP_SBC_1	0.25
p.G920S	DO41379	UCEC	ICGC	PCTST	DEG_SPOP_SBC_1	0.25
p.G915C	DO230342	COCA	ICGC	PCTST	DEG_SPOP_SBC_1	0.1111
p.G915V	DO229018	LICA	ICGC	PCTST	DEG_SPOP_SBC_1	0.1111
p.G915V	DO220007	SARC	ICGC	PCTST	DEG_SPOP_SBC_1	0.1111
p.S929I	DO229026	LICA	ICGC	PCTST	DEG_SPOP_SBC_1	0.2778
p.D931E	DO26608	LUSC	ICGC	PCTST	DEG_SPOP_SBC_1	0.2222
p.D931E	DO27381	LUSC	ICGC	PCTST	DEG_SPOP_SBC_1	0.2222
p.T935A	SIDM00193	Colorectal Carcinoma	GDSC	PCTST	DEG_SPOP_SBC_1	0.1111
p.T935A	ACH-000991	Colon/Colorectal Cancer	CCLE	PCTST	DEG_SPOP_SBC_1	0.1111
p.T935A	SNU-81	large_intestine	COSMIC	PCTST	DEG_SPOP_SBC_1	0.1111
p.P926L	OE19	oesophagus	COSMIC	PCTST	DEG_SPOP_SBC_1	0.7582
p.P921L	SK-MEL-30	skin	COSMIC	PCTST	DEG_SPOP_SBC_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14917	Protocadherin-17	DEG_SPOP_SBC_1	1046:1050	PCTST	SPOP	0.9985	More...
Q01851	POU domain, class 4, transcription factor 1	DEG_SPOP_SBC_1	89:93	PCTST	SPOP	0.8746	More...
Q12816	Trophinin	DEG_SPOP_SBC_1	923:927	PCTST	SPOP	0.7275	More...
Q15319	POU domain, class 4, transcription factor 3	DEG_SPOP_SBC_1	87:91	PCTST	SPOP	0.9732	More...
Q6ZN17	Protein lin-28 homolog B	DEG_SPOP_SBC_1	186:190	PCTST	SPOP	0.9507	More...
Q8IUM7	Neuronal PAS domain-containing protein 4	DEG_SPOP_SBC_1	503:507	PCTST	SPOP	0.8959	More...
Q8WW38	Zinc finger protein ZFPM2	DEG_SPOP_SBC_1	769:773	PCTST	SPOP	0.5014	More...
Q9Y2X3	Nucleolar protein 58	DEG_SPOP_SBC_1	506:510	PCTST	SPOP	0.9963	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons