DegronMD

Uniprot ID: Q6ZN17

Source protein: Protein lin-28 homolog B

Source gene: LIN28B

Class: DEG_SPOP_SBC_1

Location: 186:190

E3 ligase: SPOP

DEGRON score: 0.9507

ASA_SCORE: 73.26

COIL: 0.9066

CONS_SCORE: 0.5061

DSS_SCORE: 0.6785

HELIX: 0.059

FCONS_SCORE: 0.9382

RIG_SCORE: 0.6353

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P192T	TCGA-05-4396	LUAD	TCGA	PCTST	DEG_SPOP_SBC_1	0.2778
p.P192T	DO23838	LUAD	ICGC	PCTST	DEG_SPOP_SBC_1	0.2778
p.Q177H	TCGA-05-5428	LUAD	TCGA	PCTST	DEG_SPOP_SBC_1	0.0833
p.Q177H	TCGA-DU-7298	LGG	TCGA	PCTST	DEG_SPOP_SBC_1	0.0833
p.Q177H	DO22679	LGG	ICGC	PCTST	DEG_SPOP_SBC_1	0.0833
p.Q177H	DO229022	LICA	ICGC	PCTST	DEG_SPOP_SBC_1	0.0833
p.Q177H	DO24005	LUAD	ICGC	PCTST	DEG_SPOP_SBC_1	0.0833
p.R193G	TCGA-17-Z022	LUAD	TCGA	PCTST	DEG_SPOP_SBC_1	0.25
p.R193G	DO217850	BTCA	ICGC	PCTST	DEG_SPOP_SBC_1	0.25
p.S184T	TCGA-44-A4SU	LUAD	TCGA	PCTST	DEG_SPOP_SBC_1	0.2778
p.S184T	DO24507	LUAD	ICGC	PCTST	DEG_SPOP_SBC_1	0.2778
p.L191F	TCGA-DF-A2KU	UCEC	TCGA	PCTST	DEG_SPOP_SBC_1	0.3056
p.L191F	DO223286	UCEC	ICGC	PCTST	DEG_SPOP_SBC_1	0.3056
p.G178E	TCGA-DQ-5624	HNSC	TCGA	PCTST	DEG_SPOP_SBC_1	0.1111
p.G178E	TCGA-EE-A2GC	SKCM	TCGA	PCTST	DEG_SPOP_SBC_1	0.1111
p.G178E	DO14158	HNSC	ICGC	PCTST	DEG_SPOP_SBC_1	0.1111
p.G178E	DO37839	SKCM	ICGC	PCTST	DEG_SPOP_SBC_1	0.1111
p.E183Q	TCGA-EB-A41B	SKCM	TCGA	PCTST	DEG_SPOP_SBC_1	0.25
p.E183Q	DO37611	SKCM	ICGC	PCTST	DEG_SPOP_SBC_1	0.25
p.S189L	TCGA-EE-A29L	SKCM	TCGA	PCTST	DEG_SPOP_SBC_1	0.7667
p.S189L	DO222599	MELA	ICGC	PCTST	DEG_SPOP_SBC_1	0.7667
p.S189L	DO37835	SKCM	ICGC	PCTST	DEG_SPOP_SBC_1	0.7667
p.G196R	TCGA-GN-A266	SKCM	TCGA	PCTST	DEG_SPOP_SBC_1	0.1667
p.G196R	DO37432	SKCM	ICGC	PCTST	DEG_SPOP_SBC_1	0.1667
p.R179T	TCGA-PN-A8MA	CESC	TCGA	PCTST	DEG_SPOP_SBC_1	0.1389
p.R179T	DO49982	CESC	ICGC	PCTST	DEG_SPOP_SBC_1	0.1389
p.A182V	DO222765	COCA	ICGC	PCTST	DEG_SPOP_SBC_1	0.2222
p.G198R	DO228424	MALY	ICGC	PCTST	DEG_SPOP_SBC_1	0.1111
p.A182E	RCC-MF	kidney	COSMIC	PCTST	DEG_SPOP_SBC_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14917	Protocadherin-17	DEG_SPOP_SBC_1	1046:1050	PCTST	SPOP	0.9985	More...
Q01851	POU domain, class 4, transcription factor 1	DEG_SPOP_SBC_1	89:93	PCTST	SPOP	0.8746	More...
Q12816	Trophinin	DEG_SPOP_SBC_1	923:927	PCTST	SPOP	0.7275	More...
Q15319	POU domain, class 4, transcription factor 3	DEG_SPOP_SBC_1	87:91	PCTST	SPOP	0.9732	More...
Q6ZN17	Protein lin-28 homolog B	DEG_SPOP_SBC_1	186:190	PCTST	SPOP	0.9507	More...
Q8IUM7	Neuronal PAS domain-containing protein 4	DEG_SPOP_SBC_1	503:507	PCTST	SPOP	0.8959	More...
Q8WW38	Zinc finger protein ZFPM2	DEG_SPOP_SBC_1	769:773	PCTST	SPOP	0.5014	More...
Q9Y2X3	Nucleolar protein 58	DEG_SPOP_SBC_1	506:510	PCTST	SPOP	0.9963	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PCTST

Degron related mutations and impact score

Drug responses associated with LIN28B mutations

All proteins holding degron of PCTST