DegronMD - Q6ZN17(LIN28B)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P192T	TCGA-05-4396	LUAD	TCGA	PCTST	DEG_SPOP_SBC_1	186:190	Mutation rewiring degron network	0.2778
p.P192T	DO23838	LUAD	ICGC	PCTST	DEG_SPOP_SBC_1	186:190	Mutation rewiring degron network	0.2778
p.Q177H	TCGA-05-5428	LUAD	TCGA	PCTST	DEG_SPOP_SBC_1	186:190	Mutation rewiring degron network	0.0833
p.Q177H	TCGA-DU-7298	LGG	TCGA	PCTST	DEG_SPOP_SBC_1	186:190	Mutation rewiring degron network	0.0833
p.Q177H	DO22679	LGG	ICGC	PCTST	DEG_SPOP_SBC_1	186:190	Mutation rewiring degron network	0.0833
p.Q177H	DO229022	LICA	ICGC	PCTST	DEG_SPOP_SBC_1	186:190	Mutation rewiring degron network	0.0833
p.Q177H	DO24005	LUAD	ICGC	PCTST	DEG_SPOP_SBC_1	186:190	Mutation rewiring degron network	0.0833
p.R193G	TCGA-17-Z022	LUAD	TCGA	PCTST	DEG_SPOP_SBC_1	186:190	Mutation rewiring degron network	0.25
p.R193G	DO217850	BTCA	ICGC	PCTST	DEG_SPOP_SBC_1	186:190	Mutation rewiring degron network	0.25
p.S184T	TCGA-44-A4SU	LUAD	TCGA	PCTST	DEG_SPOP_SBC_1	186:190	Mutation rewiring degron network	0.2778
p.S184T	DO24507	LUAD	ICGC	PCTST	DEG_SPOP_SBC_1	186:190	Mutation rewiring degron network	0.2778
p.L191F	TCGA-DF-A2KU	UCEC	TCGA	PCTST	DEG_SPOP_SBC_1	186:190	Mutation rewiring degron network	0.3056
p.L191F	DO223286	UCEC	ICGC	PCTST	DEG_SPOP_SBC_1	186:190	Mutation rewiring degron network	0.3056
p.G178E	TCGA-DQ-5624	HNSC	TCGA	PCTST	DEG_SPOP_SBC_1	186:190	Mutation rewiring degron network	0.1111
p.G178E	TCGA-EE-A2GC	SKCM	TCGA	PCTST	DEG_SPOP_SBC_1	186:190	Mutation rewiring degron network	0.1111
p.G178E	DO14158	HNSC	ICGC	PCTST	DEG_SPOP_SBC_1	186:190	Mutation rewiring degron network	0.1111
p.G178E	DO37839	SKCM	ICGC	PCTST	DEG_SPOP_SBC_1	186:190	Mutation rewiring degron network	0.1111
p.E183Q	TCGA-EB-A41B	SKCM	TCGA	PCTST	DEG_SPOP_SBC_1	186:190	Mutation rewiring degron network	0.25
p.E183Q	DO37611	SKCM	ICGC	PCTST	DEG_SPOP_SBC_1	186:190	Mutation rewiring degron network	0.25
p.S189L	TCGA-EE-A29L	SKCM	TCGA	PCTST	DEG_SPOP_SBC_1	186:190	Mutation altering degron motif	0.7667
p.S189L	DO222599	MELA	ICGC	PCTST	DEG_SPOP_SBC_1	186:190	Mutation altering degron motif	0.7667
p.S189L	DO37835	SKCM	ICGC	PCTST	DEG_SPOP_SBC_1	186:190	Mutation altering degron motif	0.7667
p.G196R	TCGA-GN-A266	SKCM	TCGA	PCTST	DEG_SPOP_SBC_1	186:190	Mutation rewiring degron network	0.1667
p.G196R	DO37432	SKCM	ICGC	PCTST	DEG_SPOP_SBC_1	186:190	Mutation rewiring degron network	0.1667
p.R179T	TCGA-PN-A8MA	CESC	TCGA	PCTST	DEG_SPOP_SBC_1	186:190	Mutation rewiring degron network	0.1389
p.R179T	DO49982	CESC	ICGC	PCTST	DEG_SPOP_SBC_1	186:190	Mutation rewiring degron network	0.1389
p.A182V	DO222765	COCA	ICGC	PCTST	DEG_SPOP_SBC_1	186:190	Mutation rewiring degron network	0.2222
p.G198R	DO228424	MALY	ICGC	PCTST	DEG_SPOP_SBC_1	186:190	Mutation rewiring degron network	0.1111
p.A182E	RCC-MF	kidney	COSMIC	PCTST	DEG_SPOP_SBC_1	186:190	Mutation rewiring degron network	0.2222

Kaplan plot for LIN28B in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

LIN28B

UniProt ID: Q6ZN17

Entrez ID: 389421

Protein name: Protein lin-28 homolog B (Lin-28B)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for LIN28B in