DegronMD - Q8WW38(ZFPM2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L761P	TCGA-2H-A9GF	ESCA	TCGA	PCTST	DEG_SPOP_SBC_1	769:773	Mutation rewiring degron network	0.1111
p.G779R	TCGA-55-8207	LUAD	TCGA	PCTST	DEG_SPOP_SBC_1	769:773	Mutation rewiring degron network	0.1667
p.G779R	DO45351	LUAD	ICGC	PCTST	DEG_SPOP_SBC_1	769:773	Mutation rewiring degron network	0.1667
p.P776T	TCGA-61-1913	OV	TCGA	PCTST	DEG_SPOP_SBC_1	769:773	Mutation rewiring degron network	0.25
p.P776T	DO32069	OV	ICGC	PCTST	DEG_SPOP_SBC_1	769:773	Mutation rewiring degron network	0.25
p.C770S	TCGA-AA-3831	COAD	TCGA	PCTST	DEG_SPOP_SBC_1	769:773	Mutation altering degron motif	0.643
p.C770S	DO8538	COAD	ICGC	PCTST	DEG_SPOP_SBC_1	769:773	Mutation altering degron motif	0.643
p.P776S	TCGA-CA-6717	COAD	TCGA	PCTST	DEG_SPOP_SBC_1	769:773	Mutation rewiring degron network	0.25
p.P776S	DO8264	COAD	ICGC	PCTST	DEG_SPOP_SBC_1	769:773	Mutation rewiring degron network	0.25
p.P769H	TCGA-EE-A2GR	SKCM	TCGA	PCTST	DEG_SPOP_SBC_1	769:773	Mutation altering degron motif	0.7694
p.P769H	DO37996	SKCM	ICGC	PCTST	DEG_SPOP_SBC_1	769:773	Mutation altering degron motif	0.7694
p.T771I	TCGA-EO-A3AY	UCEC	TCGA	PCTST	DEG_SPOP_SBC_1	769:773	Mutation altering degron motif	0.7078
p.T771I	DO43202	UCEC	ICGC	PCTST	DEG_SPOP_SBC_1	769:773	Mutation altering degron motif	0.7078
p.L780I	TCGA-EO-A3AY	UCEC	TCGA	PCTST	DEG_SPOP_SBC_1	769:773	Mutation rewiring degron network	0.1389
p.L780I	DO43202	UCEC	ICGC	PCTST	DEG_SPOP_SBC_1	769:773	Mutation rewiring degron network	0.1389
p.P769S	TCGA-FS-A1Z3	SKCM	TCGA	PCTST	DEG_SPOP_SBC_1	769:773	Mutation altering degron motif	0.6752
p.P769S	DO37635	SKCM	ICGC	PCTST	DEG_SPOP_SBC_1	769:773	Mutation altering degron motif	0.6752
p.Q774L	TCGA-L9-A7SV	LUAD	TCGA	PCTST	DEG_SPOP_SBC_1	769:773	Mutation rewiring degron network	0.3056
p.Q774L	DO49875	LUAD	ICGC	PCTST	DEG_SPOP_SBC_1	769:773	Mutation rewiring degron network	0.3056
p.D762Y	TCGA-NJ-A4YF	LUAD	TCGA	PCTST	DEG_SPOP_SBC_1	769:773	Mutation rewiring degron network	0.1389
p.D762Y	DO218940	LUAD	ICGC	PCTST	DEG_SPOP_SBC_1	769:773	Mutation rewiring degron network	0.1389
p.G781E	TCGA-YD-A89C	SKCM	TCGA	PCTST	DEG_SPOP_SBC_1	769:773	Mutation rewiring degron network	0.1111
p.G781E	DO219501	SKCM	ICGC	PCTST	DEG_SPOP_SBC_1	769:773	Mutation rewiring degron network	0.1111
p.N765S	DO222973	BTCA	ICGC	PCTST	DEG_SPOP_SBC_1	769:773	Mutation rewiring degron network	0.2222
p.T771A	DO228656	GACA	ICGC	PCTST	DEG_SPOP_SBC_1	769:773	Mutation altering degron motif	0.7139
p.L761R	DO233949	GACA	ICGC	PCTST	DEG_SPOP_SBC_1	769:773	Mutation rewiring degron network	0.1111
p.L761I	DO231495	THCA	ICGC	PCTST	DEG_SPOP_SBC_1	769:773	Mutation rewiring degron network	0.1111
p.V763I	SIDM00718	Non-Small Cell Lung Carcinoma	GDSC	PCTST	DEG_SPOP_SBC_1	769:773	Mutation rewiring degron network	0.1667
p.V763I	SIDM01178	Other Solid Cancers	GDSC	PCTST	DEG_SPOP_SBC_1	769:773	Mutation rewiring degron network	0.1667
p.V763I	SIDM01083	Oral Cavity Carcinoma	GDSC	PCTST	DEG_SPOP_SBC_1	769:773	Mutation rewiring degron network	0.1667
p.N767S	SIDM00412	B-Cell Non-Hodgkin's Lymphoma	GDSC	PCTST	DEG_SPOP_SBC_1	769:773	Mutation rewiring degron network	0.2778
p.N767S	WSU-NHL	haematopoietic and lymphoid tissue	COSMIC	PCTST	DEG_SPOP_SBC_1	769:773	Mutation rewiring degron network	0.2778
p.S780N	SNU-1040	large intestine	COSMIC	PCTST	DEG_SPOP_SBC_1	769:773	Mutation rewiring degron network	0.1389
p.K761E	CW-2	large intestine	COSMIC	PCTST	DEG_SPOP_SBC_1	769:773	Mutation rewiring degron network	0.1111

Kaplan plot for ZFPM2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZFPM2

UniProt ID: Q8WW38

Entrez ID: 23414

Protein name: Zinc finger protein ZFPM2 (Friend of GATA protein 2) (FOG-2) (Friend of GATA 2) (hFOG-2) (Zinc finger protein 89B) (Zinc finger protein multitype 2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ZFPM2 in