DegronMD

Uniprot ID: O14917

Source protein: Protocadherin-17

Source gene: PCDH17

Class: DEG_SCF_TRCP1_1

Location: 889:895

E3 ligase: BTRC

DEGRON score: 0.9691

ASA_SCORE: 62.1429

COIL: 0.8104

CONS_SCORE: 0.5463

DSS_SCORE: 0.7308

HELIX: 0.1344

FCONS_SCORE: 1.0784

RIG_SCORE: 0.5415

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S886I	TCGA-44-A4SS	LUAD	TCGA	DSGHGDS	DEG_SCF_TRCP1_1	0.25
p.S886I	TCGA-95-7567	LUAD	TCGA	DSGHGDS	DEG_SCF_TRCP1_1	0.25
p.S886I	DO229028	LICA	ICGC	DSGHGDS	DEG_SCF_TRCP1_1	0.25
p.S886I	DO24227	LUAD	ICGC	DSGHGDS	DEG_SCF_TRCP1_1	0.25
p.S886I	DO25564	LUAD	ICGC	DSGHGDS	DEG_SCF_TRCP1_1	0.25
p.F879L	TCGA-50-6593	LUAD	TCGA	DSGHGDS	DEG_SCF_TRCP1_1	0.0556
p.F879L	DO24100	LUAD	ICGC	DSGHGDS	DEG_SCF_TRCP1_1	0.0556
p.G893V	TCGA-AD-6548	COAD	TCGA	DSGHGDS	DEG_SCF_TRCP1_1	0.6421
p.G893V	DO9586	COAD	ICGC	DSGHGDS	DEG_SCF_TRCP1_1	0.6421
p.D903G	TCGA-AX-A06F	UCEC	TCGA	DSGHGDS	DEG_SCF_TRCP1_1	0.1111
p.D903G	DO41752	UCEC	ICGC	DSGHGDS	DEG_SCF_TRCP1_1	0.1111
p.R888I	TCGA-AX-A2HC	UCEC	TCGA	DSGHGDS	DEG_SCF_TRCP1_1	0.3056
p.R888I	DO41572	UCEC	ICGC	DSGHGDS	DEG_SCF_TRCP1_1	0.3056
p.S900R	TCGA-D3-A2JF	SKCM	TCGA	DSGHGDS	DEG_SCF_TRCP1_1	0.1944
p.S900R	DO38153	SKCM	ICGC	DSGHGDS	DEG_SCF_TRCP1_1	0.1944
p.D903H	TCGA-D3-A3MR	SKCM	TCGA	DSGHGDS	DEG_SCF_TRCP1_1	0.1111
p.D903H	DO47256	SKCM	ICGC	DSGHGDS	DEG_SCF_TRCP1_1	0.1111
p.D881N	TCGA-D3-A5GN	SKCM	TCGA	DSGHGDS	DEG_SCF_TRCP1_1	0.1111
p.D881N	DO47317	SKCM	ICGC	DSGHGDS	DEG_SCF_TRCP1_1	0.1111
p.D896Y	TCGA-OR-A5KB	ACC	TCGA	DSGHGDS	DEG_SCF_TRCP1_1	0.3056
p.S886R	DO228359	LICA	ICGC	DSGHGDS	DEG_SCF_TRCP1_1	0.25
p.S895R	DO231947	LICA	ICGC	DSGHGDS	DEG_SCF_TRCP1_1	0.7427
p.G891V	DO228952	LICA	ICGC	DSGHGDS	DEG_SCF_TRCP1_1	0.7532
p.D899Y	DO228976	LICA	ICGC	DSGHGDS	DEG_SCF_TRCP1_1	0.2222
p.A885S	DO23544	LIRI	ICGC	DSGHGDS	DEG_SCF_TRCP1_1	0.2222
p.R884K	DO229177	LMS	ICGC	DSGHGDS	DEG_SCF_TRCP1_1	0.1944
p.A898G	DO227736	PACA	ICGC	DSGHGDS	DEG_SCF_TRCP1_1	0.25
p.Q897H	SIDM01943	Colorectal Carcinoma	GDSC	DSGHGDS	DEG_SCF_TRCP1_1	0.2778
p.L887V	SIDM00477	Esophageal Carcinoma	GDSC	DSGHGDS	DEG_SCF_TRCP1_1	0.2778
p.L887V	ACH-000383	Esophageal Cancer	CCLE	DSGHGDS	DEG_SCF_TRCP1_1	0.2778
p.L887V	OE33	oesophagus	COSMIC	DSGHGDS	DEG_SCF_TRCP1_1	0.2778
p.R884I	SIDM00892	Breast Carcinoma	GDSC	DSGHGDS	DEG_SCF_TRCP1_1	0.1944
p.R884I	ACH-000818	Breast Cancer	CCLE	DSGHGDS	DEG_SCF_TRCP1_1	0.1944
p.R884I	BT-483	breast	COSMIC	DSGHGDS	DEG_SCF_TRCP1_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14917	Protocadherin-17	DEG_SCF_TRCP1_1	889:895	DSGHGDS	BTRC	0.9691	More...
Q9P2E7	Protocadherin-10	DEG_SCF_TRCP1_1	910:916	DSGHGDS	BTRC	0.9662	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DSGHGDS

Degron related mutations and impact score

Drug responses associated with PCDH17 mutations

All proteins holding degron of DSGHGDS