DegronMD

Uniprot ID: Q9P2E7

Source protein: Protocadherin-10

Source gene: PCDH10

Class: DEG_SCF_TRCP1_1

Location: 910:916

E3 ligase: BTRC

DEGRON score: 0.9662

ASA_SCORE: 66.0429

COIL: 0.805

CONS_SCORE: 0.5261

DSS_SCORE: 0.7143

HELIX: 0.128

FCONS_SCORE: 1.084

RIG_SCORE: 0.5172

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G914R	TCGA-33-4586	LUSC	TCGA	DSGHGDS	DEG_SCF_TRCP1_1	0.6457
p.G914R	DO27318	LUSC	ICGC	DSGHGDS	DEG_SCF_TRCP1_1	0.6457
p.S908Y	TCGA-43-5668	LUSC	TCGA	DSGHGDS	DEG_SCF_TRCP1_1	0.2778
p.S908Y	DO26608	LUSC	ICGC	DSGHGDS	DEG_SCF_TRCP1_1	0.2778
p.D904N	TCGA-CQ-5327	HNSC	TCGA	DSGHGDS	DEG_SCF_TRCP1_1	0.1667
p.D904N	DO15878	HNSC	ICGC	DSGHGDS	DEG_SCF_TRCP1_1	0.1667
p.D924N	TCGA-FP-8211	STAD	TCGA	DSGHGDS	DEG_SCF_TRCP1_1	0.1111
p.D924N	DO47847	STAD	ICGC	DSGHGDS	DEG_SCF_TRCP1_1	0.1111
p.S921I	DO229028	LICA	ICGC	DSGHGDS	DEG_SCF_TRCP1_1	0.1944
p.D904Y	DO229027	LICA	ICGC	DSGHGDS	DEG_SCF_TRCP1_1	0.1667
p.D922N	DO222843	MELA	ICGC	DSGHGDS	DEG_SCF_TRCP1_1	0.1667
p.V906A	DO48557	PAEN	ICGC	DSGHGDS	DEG_SCF_TRCP1_1	0.2222
p.A925V	SIDM00845	Burkitt's Lymphoma	GDSC	DSGHGDS	DEG_SCF_TRCP1_1	0.0833
p.A925V	SIDM00461	Acute Myeloid Leukemia	GDSC	DSGHGDS	DEG_SCF_TRCP1_1	0.0833
p.A925V	SIDM01519	Head and Neck Carcinoma	GDSC	DSGHGDS	DEG_SCF_TRCP1_1	0.0833
p.A925V	ACH-000786	Lymphoma	CCLE	DSGHGDS	DEG_SCF_TRCP1_1	0.0833
p.A925V	ACH-000992	Head and Neck Cancer	CCLE	DSGHGDS	DEG_SCF_TRCP1_1	0.0833
p.A925S	SIDM00298	Squamous Cell Lung Carcinoma	GDSC	DSGHGDS	DEG_SCF_TRCP1_1	0.0833
p.A925S	ACH-000705	Lung Cancer	CCLE	DSGHGDS	DEG_SCF_TRCP1_1	0.0833
p.A925S	ACH-001113	Lung Cancer	CCLE	DSGHGDS	DEG_SCF_TRCP1_1	0.0833
p.A925S	ACH-002156	Lung Cancer	CCLE	DSGHGDS	DEG_SCF_TRCP1_1	0.0833
p.A925S	LC-1-sq	lung	COSMIC	DSGHGDS	DEG_SCF_TRCP1_1	0.0833
p.S907I	ACH-000870	Lung Cancer	CCLE	DSGHGDS	DEG_SCF_TRCP1_1	0.25
p.I905M	ACH-000961	Endometrial/Uterine Cancer	CCLE	DSGHGDS	DEG_SCF_TRCP1_1	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons