DegronMD - Q9P2E7(PCDH10)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Y887F	TCGA-05-4427	LUAD	TCGA	QRAELSYLV	DEG_APCC_DBOX_1	881:889	Mutation altering degron motif	0.7528
p.Y887F	DO23666	LUAD	ICGC	QRAELSYLV	DEG_APCC_DBOX_1	881:889	Mutation altering degron motif	0.7528
p.R891T	TCGA-21-5786	LUSC	TCGA	QRAELSYLV	DEG_APCC_DBOX_1	881:889	Mutation rewiring degron network	0.2778
p.R891T	DO26830	LUSC	ICGC	QRAELSYLV	DEG_APCC_DBOX_1	881:889	Mutation rewiring degron network	0.2778
p.G914R	TCGA-33-4586	LUSC	TCGA	DSGHGDS	DEG_SCF_TRCP1_1	910:916	Mutation altering degron motif	0.6457
p.G914R	DO27318	LUSC	ICGC	DSGHGDS	DEG_SCF_TRCP1_1	910:916	Mutation altering degron motif	0.6457
p.D890V	TCGA-34-5928	LUSC	TCGA	QRAELSYLV	DEG_APCC_DBOX_1	881:889	Mutation rewiring degron network	0.3056
p.D890V	DO27461	LUSC	ICGC	QRAELSYLV	DEG_APCC_DBOX_1	881:889	Mutation rewiring degron network	0.3056
p.S908Y	TCGA-43-5668	LUSC	TCGA	DSGHGDS	DEG_SCF_TRCP1_1	910:916	Mutation rewiring degron network	0.2778
p.S908Y	DO26608	LUSC	ICGC	DSGHGDS	DEG_SCF_TRCP1_1	910:916	Mutation rewiring degron network	0.2778
p.S886R	TCGA-56-7223	LUSC	TCGA	QRAELSYLV	DEG_APCC_DBOX_1	881:889	Mutation altering degron motif	0.6316
p.S886R	DO26999	LUSC	ICGC	QRAELSYLV	DEG_APCC_DBOX_1	881:889	Mutation altering degron motif	0.6316
p.R893C	TCGA-A5-A0G2	UCEC	TCGA	QRAELSYLV	DEG_APCC_DBOX_1	881:889	Mutation rewiring degron network	0.2222
p.R893C	DO41235	UCEC	ICGC	QRAELSYLV	DEG_APCC_DBOX_1	881:889	Mutation rewiring degron network	0.2222
p.R894Q	TCGA-BR-8680	STAD	TCGA	QRAELSYLV	DEG_APCC_DBOX_1	881:889	Mutation rewiring degron network	0.1944
p.R894Q	DO47769	STAD	ICGC	QRAELSYLV	DEG_APCC_DBOX_1	881:889	Mutation rewiring degron network	0.1944
p.D904N	TCGA-CQ-5327	HNSC	TCGA	DSGHGDS	DEG_SCF_TRCP1_1	910:916	Mutation rewiring degron network	0.1667
p.D904N	DO15878	HNSC	ICGC	DSGHGDS	DEG_SCF_TRCP1_1	910:916	Mutation rewiring degron network	0.1667
p.G871R	TCGA-D3-A8GI	SKCM	TCGA	QRAELSYLV	DEG_APCC_DBOX_1	881:889	Mutation rewiring degron network	0.0556
p.G871R	DO50284	SKCM	ICGC	QRAELSYLV	DEG_APCC_DBOX_1	881:889	Mutation rewiring degron network	0.0556
p.N896H	TCGA-DD-A3A2	LIHC	TCGA	QRAELSYLV	DEG_APCC_DBOX_1	881:889	Mutation rewiring degron network	0.1389
p.N896H	DO44881	LIHC	ICGC	QRAELSYLV	DEG_APCC_DBOX_1	881:889	Mutation rewiring degron network	0.1389
p.D924N	TCGA-FP-8211	STAD	TCGA	DSGHGDS	DEG_SCF_TRCP1_1	910:916	Mutation rewiring degron network	0.1111
p.D924N	DO47847	STAD	ICGC	DSGHGDS	DEG_SCF_TRCP1_1	910:916	Mutation rewiring degron network	0.1111
p.D890N	TCGA-XK-AAJT	PRAD	TCGA	QRAELSYLV	DEG_APCC_DBOX_1	881:889	Mutation rewiring degron network	0.3056
p.D890N	DO51414	PRAD	ICGC	QRAELSYLV	DEG_APCC_DBOX_1	881:889	Mutation rewiring degron network	0.3056
p.S921I	DO229028	LICA	ICGC	DSGHGDS	DEG_SCF_TRCP1_1	910:916	Mutation rewiring degron network	0.1944
p.D904Y	DO229027	LICA	ICGC	DSGHGDS	DEG_SCF_TRCP1_1	910:916	Mutation rewiring degron network	0.1667
p.S886I	DO229031	LICA	ICGC	QRAELSYLV	DEG_APCC_DBOX_1	881:889	Mutation altering degron motif	0.623
p.E884D	DO50951	LICA	ICGC	QRAELSYLV	DEG_APCC_DBOX_1	881:889	Mutation altering degron motif	0.5647
p.L885H	DO23122	LINC	ICGC	QRAELSYLV	DEG_APCC_DBOX_1	881:889	Mutation altering degron motif	0.7313
p.Y887H	DO45189	LIRI	ICGC	QRAELSYLV	DEG_APCC_DBOX_1	881:889	Mutation altering degron motif	0.7229
p.D922N	DO222843	MELA	ICGC	DSGHGDS	DEG_SCF_TRCP1_1	910:916	Mutation rewiring degron network	0.1667
p.S875T	DO51469	PACA	ICGC	QRAELSYLV	DEG_APCC_DBOX_1	881:889	Mutation rewiring degron network	0.1667
p.V906A	DO48557	PAEN	ICGC	DSGHGDS	DEG_SCF_TRCP1_1	910:916	Mutation rewiring degron network	0.2222
p.S875P	DO229113	PRAD	ICGC	QRAELSYLV	DEG_APCC_DBOX_1	881:889	Mutation rewiring degron network	0.1667
p.T878N	SIDM00845	Burkitt's Lymphoma	GDSC	QRAELSYLV	DEG_APCC_DBOX_1	881:889	Mutation rewiring degron network	0.25
p.A925V	SIDM00845	Burkitt's Lymphoma	GDSC	DSGHGDS	DEG_SCF_TRCP1_1	910:916	Mutation rewiring degron network	0.0833
p.A925V	SIDM00461	Acute Myeloid Leukemia	GDSC	DSGHGDS	DEG_SCF_TRCP1_1	910:916	Mutation rewiring degron network	0.0833
p.A925V	SIDM01519	Head and Neck Carcinoma	GDSC	DSGHGDS	DEG_SCF_TRCP1_1	910:916	Mutation rewiring degron network	0.0833
p.A925V	ACH-000786	Lymphoma	CCLE	DSGHGDS	DEG_SCF_TRCP1_1	910:916	Mutation rewiring degron network	0.0833
p.A925V	ACH-000992	Head and Neck Cancer	CCLE	DSGHGDS	DEG_SCF_TRCP1_1	910:916	Mutation rewiring degron network	0.0833
p.R882G	SIDM00538	Esophageal Carcinoma	GDSC	QRAELSYLV	DEG_APCC_DBOX_1	881:889	Mutation altering degron motif	0.7568
p.R882G	ACH-001497	Esophageal Cancer	CCLE	QRAELSYLV	DEG_APCC_DBOX_1	881:889	Mutation altering degron motif	0.7568
p.R882G	ESO51	oesophagus	COSMIC	QRAELSYLV	DEG_APCC_DBOX_1	881:889	Mutation altering degron motif	0.7568
p.A925S	SIDM00298	Squamous Cell Lung Carcinoma	GDSC	DSGHGDS	DEG_SCF_TRCP1_1	910:916	Mutation rewiring degron network	0.0833
p.A925S	ACH-000705	Lung Cancer	CCLE	DSGHGDS	DEG_SCF_TRCP1_1	910:916	Mutation rewiring degron network	0.0833
p.A925S	ACH-001113	Lung Cancer	CCLE	DSGHGDS	DEG_SCF_TRCP1_1	910:916	Mutation rewiring degron network	0.0833
p.A925S	ACH-002156	Lung Cancer	CCLE	DSGHGDS	DEG_SCF_TRCP1_1	910:916	Mutation rewiring degron network	0.0833
p.A925S	LC-1-sq	lung	COSMIC	DSGHGDS	DEG_SCF_TRCP1_1	910:916	Mutation rewiring degron network	0.0833
p.L887R	SIDM00730	Small Cell Lung Carcinoma	GDSC	QRAELSYLV	DEG_APCC_DBOX_1	881:889	Mutation altering degron motif	0.8428
p.L887R	NCI-H2227	lung	COSMIC	QRAELSYLV	DEG_APCC_DBOX_1	881:889	Mutation altering degron motif	0.8428
p.K881N	SIDM01343	Gastric Carcinoma	GDSC	QRAELSYLV	DEG_APCC_DBOX_1	881:889	Mutation altering degron motif	0.6918
p.S907I	ACH-000870	Lung Cancer	CCLE	DSGHGDS	DEG_SCF_TRCP1_1	910:916	Mutation rewiring degron network	0.25
p.I905M	ACH-000961	Endometrial/Uterine Cancer	CCLE	DSGHGDS	DEG_SCF_TRCP1_1	910:916	Mutation rewiring degron network	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PCDH10

UniProt ID: Q9P2E7

Entrez ID: 57575

Protein name: Protocadherin-10

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for PCDH10 in