DegronMD

Uniprot ID: Q9P2E7

Source protein: Protocadherin-10

Source gene: PCDH10

Class: DEG_APCC_DBOX_1

Location: 881:889

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.916

ASA_SCORE: 71.2222

COIL: 0.4419

CONS_SCORE: 0.4546

DSS_SCORE: 0.4549

HELIX: 0.4818

FCONS_SCORE: 0.977

RIG_SCORE: 0.7892

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Y887F	TCGA-05-4427	LUAD	TCGA	QRAELSYLV	DEG_APCC_DBOX_1	0.7528
p.Y887F	DO23666	LUAD	ICGC	QRAELSYLV	DEG_APCC_DBOX_1	0.7528
p.R891T	TCGA-21-5786	LUSC	TCGA	QRAELSYLV	DEG_APCC_DBOX_1	0.2778
p.R891T	DO26830	LUSC	ICGC	QRAELSYLV	DEG_APCC_DBOX_1	0.2778
p.D890V	TCGA-34-5928	LUSC	TCGA	QRAELSYLV	DEG_APCC_DBOX_1	0.3056
p.D890V	DO27461	LUSC	ICGC	QRAELSYLV	DEG_APCC_DBOX_1	0.3056
p.S886R	TCGA-56-7223	LUSC	TCGA	QRAELSYLV	DEG_APCC_DBOX_1	0.6316
p.S886R	DO26999	LUSC	ICGC	QRAELSYLV	DEG_APCC_DBOX_1	0.6316
p.R893C	TCGA-A5-A0G2	UCEC	TCGA	QRAELSYLV	DEG_APCC_DBOX_1	0.2222
p.R893C	DO41235	UCEC	ICGC	QRAELSYLV	DEG_APCC_DBOX_1	0.2222
p.R894Q	TCGA-BR-8680	STAD	TCGA	QRAELSYLV	DEG_APCC_DBOX_1	0.1944
p.R894Q	DO47769	STAD	ICGC	QRAELSYLV	DEG_APCC_DBOX_1	0.1944
p.G871R	TCGA-D3-A8GI	SKCM	TCGA	QRAELSYLV	DEG_APCC_DBOX_1	0.0556
p.G871R	DO50284	SKCM	ICGC	QRAELSYLV	DEG_APCC_DBOX_1	0.0556
p.N896H	TCGA-DD-A3A2	LIHC	TCGA	QRAELSYLV	DEG_APCC_DBOX_1	0.1389
p.N896H	DO44881	LIHC	ICGC	QRAELSYLV	DEG_APCC_DBOX_1	0.1389
p.D890N	TCGA-XK-AAJT	PRAD	TCGA	QRAELSYLV	DEG_APCC_DBOX_1	0.3056
p.D890N	DO51414	PRAD	ICGC	QRAELSYLV	DEG_APCC_DBOX_1	0.3056
p.S886I	DO229031	LICA	ICGC	QRAELSYLV	DEG_APCC_DBOX_1	0.623
p.E884D	DO50951	LICA	ICGC	QRAELSYLV	DEG_APCC_DBOX_1	0.5647
p.L885H	DO23122	LINC	ICGC	QRAELSYLV	DEG_APCC_DBOX_1	0.7313
p.Y887H	DO45189	LIRI	ICGC	QRAELSYLV	DEG_APCC_DBOX_1	0.7229
p.S875T	DO51469	PACA	ICGC	QRAELSYLV	DEG_APCC_DBOX_1	0.1667
p.S875P	DO229113	PRAD	ICGC	QRAELSYLV	DEG_APCC_DBOX_1	0.1667
p.T878N	SIDM00845	Burkitt's Lymphoma	GDSC	QRAELSYLV	DEG_APCC_DBOX_1	0.25
p.R882G	SIDM00538	Esophageal Carcinoma	GDSC	QRAELSYLV	DEG_APCC_DBOX_1	0.7568
p.R882G	ACH-001497	Esophageal Cancer	CCLE	QRAELSYLV	DEG_APCC_DBOX_1	0.7568
p.R882G	ESO51	oesophagus	COSMIC	QRAELSYLV	DEG_APCC_DBOX_1	0.7568
p.L887R	SIDM00730	Small Cell Lung Carcinoma	GDSC	QRAELSYLV	DEG_APCC_DBOX_1	0.8428
p.L887R	NCI-H2227	lung	COSMIC	QRAELSYLV	DEG_APCC_DBOX_1	0.8428
p.K881N	SIDM01343	Gastric Carcinoma	GDSC	QRAELSYLV	DEG_APCC_DBOX_1	0.6918

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: QRAELSYLV

Degron related mutations and impact score

Drug responses associated with PCDH10 mutations

All proteins holding degron of QRAELSYLV

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9P2E7	Protocadherin-10	DEG_APCC_DBOX_1	881:889	QRAELSYLV	APC,CDC20,FZR1	0.916	More...