DegronMD

Uniprot ID: O14917

Source protein: Protocadherin-17

Source gene: PCDH17

Class: DEG_SPOP_SBC_1

Location: 873:877

E3 ligase: SPOP

DEGRON score: 0.8664

ASA_SCORE: 63.86

COIL: 0.5148

CONS_SCORE: 0.5704

DSS_SCORE: 0.6623

HELIX: 0.1352

FCONS_SCORE: 1.1585

RIG_SCORE: 0.6781

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S886I	TCGA-44-A4SS	LUAD	TCGA	VQSSS	DEG_SPOP_SBC_1	0.0833
p.S886I	TCGA-95-7567	LUAD	TCGA	VQSSS	DEG_SPOP_SBC_1	0.0833
p.S886I	DO229028	LICA	ICGC	VQSSS	DEG_SPOP_SBC_1	0.0833
p.S886I	DO24227	LUAD	ICGC	VQSSS	DEG_SPOP_SBC_1	0.0833
p.S886I	DO25564	LUAD	ICGC	VQSSS	DEG_SPOP_SBC_1	0.0833
p.F879L	TCGA-50-6593	LUAD	TCGA	VQSSS	DEG_SPOP_SBC_1	0.2778
p.F879L	DO24100	LUAD	ICGC	VQSSS	DEG_SPOP_SBC_1	0.2778
p.G867C	TCGA-55-6978	LUAD	TCGA	VQSSS	DEG_SPOP_SBC_1	0.1667
p.G867C	DO23625	LUAD	ICGC	VQSSS	DEG_SPOP_SBC_1	0.1667
p.Q874E	TCGA-63-A5MW	LUSC	TCGA	VQSSS	DEG_SPOP_SBC_1	0.5633
p.Q874E	DO219169	LUSC	ICGC	VQSSS	DEG_SPOP_SBC_1	0.5633
p.Q870P	TCGA-BH-A0BZ	BRCA	TCGA	VQSSS	DEG_SPOP_SBC_1	0.25
p.Q870P	DO1396	BRCA	ICGC	VQSSS	DEG_SPOP_SBC_1	0.25
p.D881N	TCGA-D3-A5GN	SKCM	TCGA	VQSSS	DEG_SPOP_SBC_1	0.2222
p.D881N	DO47317	SKCM	ICGC	VQSSS	DEG_SPOP_SBC_1	0.2222
p.M866L	TCGA-VQ-A8DU	STAD	TCGA	VQSSS	DEG_SPOP_SBC_1	0.1389
p.M866L	DO51752	STAD	ICGC	VQSSS	DEG_SPOP_SBC_1	0.1389
p.T878M	DO233749	GACA	ICGC	VQSSS	DEG_SPOP_SBC_1	0.3056
p.T878M	DO228851	MALY	ICGC	VQSSS	DEG_SPOP_SBC_1	0.3056
p.S886R	DO228359	LICA	ICGC	VQSSS	DEG_SPOP_SBC_1	0.0833
p.S876I	DO229045	LICA	ICGC	VQSSS	DEG_SPOP_SBC_1	0.7341
p.G867V	DO229009	LICA	ICGC	VQSSS	DEG_SPOP_SBC_1	0.1667
p.A885S	DO23544	LIRI	ICGC	VQSSS	DEG_SPOP_SBC_1	0.1111
p.R884K	DO229177	LMS	ICGC	VQSSS	DEG_SPOP_SBC_1	0.1389
p.L887V	SIDM00477	Esophageal Carcinoma	GDSC	VQSSS	DEG_SPOP_SBC_1	0.0556
p.L887V	ACH-000383	Esophageal Cancer	CCLE	VQSSS	DEG_SPOP_SBC_1	0.0556
p.L887V	OE33	oesophagus	COSMIC	VQSSS	DEG_SPOP_SBC_1	0.0556
p.R884I	SIDM00892	Breast Carcinoma	GDSC	VQSSS	DEG_SPOP_SBC_1	0.1389
p.R884I	ACH-000818	Breast Cancer	CCLE	VQSSS	DEG_SPOP_SBC_1	0.1389
p.R884I	BT-483	breast	COSMIC	VQSSS	DEG_SPOP_SBC_1	0.1389
p.F872L	SIDM00016	Neuroblastoma	GDSC	VQSSS	DEG_SPOP_SBC_1	0.3056
p.F872L	ACH-000446	Neuroblastoma	CCLE	VQSSS	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14917	Protocadherin-17	DEG_SPOP_SBC_1	873:877	VQSSS	SPOP	0.8664	More...
P49792	E3 SUMO-protein ligase RanBP2	DEG_SPOP_SBC_1	926:930	VQSSS	SPOP	0.9967	More...
Q6ZW76	Ankyrin repeat and SAM domain-containing protein 3	DEG_SPOP_SBC_1	348:352	VQSSS	SPOP	0.9789	More...
Q8TCU4	Alstrom syndrome protein 1	DEG_SPOP_SBC_1	759:763	VQSSS	SPOP	0.9855	More...
Q8TCU4	Alstrom syndrome protein 1	DEG_SPOP_SBC_1	1045:1049	VQSSS	SPOP	0.9519	More...
Q96QF7	Germ cell nuclear acidic protein	DEG_SPOP_SBC_1	25:29	VQSSS	SPOP	0.9667	More...
Q9H2G4	Testis-specific Y-encoded-like protein 2	DEG_SPOP_SBC_1	135:139	VQSSS	SPOP	0.7915	More...
Q9NWH9	SAFB-like transcription modulator	DEG_SPOP_SBC_1	785:789	VQSSS	SPOP	0.9787	More...
Q9NYQ7	Cadherin EGF LAG seven-pass G-type receptor 3	DEG_SPOP_SBC_1	3261:3265	VQSSS	SPOP	0.715	More...
Q9UKI8	Serine/threonine-protein kinase tousled-like 1	DEG_SPOP_SBC_1	3:7	VQSSS	SPOP	0.6227	More...
Q9Y613	FH1/FH2 domain-containing protein 1	DEG_SPOP_SBC_1	1074:1078	VQSSS	SPOP	0.7081	More...
Q8WUF8	Cotranscriptional regulator FAM172A	DEG_SPOP_SBC_1	213:217	VQSSS	SPOP	0.9808	More...
Q2KHR3	Glutamine and serine-rich protein 1	DEG_SPOP_SBC_1	519:523	VQSSS	SPOP	0.9359	More...
Q6ZS46	Putative uncharacterized protein FLJ45840	DEG_SPOP_SBC_1	16:20	VQSSS	SPOP	0.8662	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VQSSS

Degron related mutations and impact score

Drug responses associated with PCDH17 mutations

All proteins holding degron of VQSSS