DegronMD

Uniprot ID: Q8TCU4

Source protein: Alstrom syndrome protein 1

Source gene: ALMS1

Class: DEG_SPOP_SBC_1

Location: 759:763

E3 ligase: SPOP

DEGRON score: 0.9855

ASA_SCORE: 87.7

COIL: 0.9002

CONS_SCORE: 0.2738

DSS_SCORE: 0.6471

HELIX: 0.0266

FCONS_SCORE: 1.0018

RIG_SCORE: 0.6644

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S762A	TCGA-AP-A056	UCEC	TCGA	VQSSS	DEG_SPOP_SBC_1	0.7588
p.S762A	DO43971	UCEC	ICGC	VQSSS	DEG_SPOP_SBC_1	0.7588
p.T753N	TCGA-DU-6392	LGG	TCGA	VQSSS	DEG_SPOP_SBC_1	0.2778
p.T753N	DO22237	LGG	ICGC	VQSSS	DEG_SPOP_SBC_1	0.2778
p.P769S	TCGA-EE-A3AF	SKCM	TCGA	VQSSS	DEG_SPOP_SBC_1	0.6111
p.P769S	DO50946	LICA	ICGC	VQSSS	DEG_SPOP_SBC_1	0.6111
p.P769S	DO37911	SKCM	ICGC	VQSSS	DEG_SPOP_SBC_1	0.6111
p.S764L	TCGA-G2-A3VY	BLCA	TCGA	VQSSS	DEG_SPOP_SBC_1	0.75
p.S764L	DO590	BLCA	ICGC	VQSSS	DEG_SPOP_SBC_1	0.75
p.S762F	TCGA-IR-A3LH	CESC	TCGA	VQSSS	DEG_SPOP_SBC_1	0.7982
p.S762F	DO44381	CESC	ICGC	VQSSS	DEG_SPOP_SBC_1	0.7982
p.S761T	DO222643	BTCA	ICGC	VQSSS	DEG_SPOP_SBC_1	0.6005
p.S761T	ACH-000582	Skin Cancer	CCLE	VQSSS	DEG_SPOP_SBC_1	0.6005
p.K757E	DO15294	HNSC	ICGC	VQSSS	DEG_SPOP_SBC_1	0.2778
p.L760Q	DO44828	LICA	ICGC	VQSSS	DEG_SPOP_SBC_1	0.7765
p.E772D	DO24740	LUAD	ICGC	VQSSS	DEG_SPOP_SBC_1	0.0833
p.S762T	SIDM01483	Melanoma	GDSC	VQSSS	DEG_SPOP_SBC_1	0.6005
p.S762T	COLO-741	large_intestine	COSMIC	VQSSS	DEG_SPOP_SBC_1	0.6005
p.Q757R	MCC26	skin	COSMIC	VQSSS	DEG_SPOP_SBC_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14917	Protocadherin-17	DEG_SPOP_SBC_1	873:877	VQSSS	SPOP	0.8664	More...
P49792	E3 SUMO-protein ligase RanBP2	DEG_SPOP_SBC_1	926:930	VQSSS	SPOP	0.9967	More...
Q6ZW76	Ankyrin repeat and SAM domain-containing protein 3	DEG_SPOP_SBC_1	348:352	VQSSS	SPOP	0.9789	More...
Q8TCU4	Alstrom syndrome protein 1	DEG_SPOP_SBC_1	759:763	VQSSS	SPOP	0.9855	More...
Q8TCU4	Alstrom syndrome protein 1	DEG_SPOP_SBC_1	1045:1049	VQSSS	SPOP	0.9519	More...
Q96QF7	Germ cell nuclear acidic protein	DEG_SPOP_SBC_1	25:29	VQSSS	SPOP	0.9667	More...
Q9H2G4	Testis-specific Y-encoded-like protein 2	DEG_SPOP_SBC_1	135:139	VQSSS	SPOP	0.7915	More...
Q9NWH9	SAFB-like transcription modulator	DEG_SPOP_SBC_1	785:789	VQSSS	SPOP	0.9787	More...
Q9NYQ7	Cadherin EGF LAG seven-pass G-type receptor 3	DEG_SPOP_SBC_1	3261:3265	VQSSS	SPOP	0.715	More...
Q9UKI8	Serine/threonine-protein kinase tousled-like 1	DEG_SPOP_SBC_1	3:7	VQSSS	SPOP	0.6227	More...
Q9Y613	FH1/FH2 domain-containing protein 1	DEG_SPOP_SBC_1	1074:1078	VQSSS	SPOP	0.7081	More...
Q8WUF8	Cotranscriptional regulator FAM172A	DEG_SPOP_SBC_1	213:217	VQSSS	SPOP	0.9808	More...
Q2KHR3	Glutamine and serine-rich protein 1	DEG_SPOP_SBC_1	519:523	VQSSS	SPOP	0.9359	More...
Q6ZS46	Putative uncharacterized protein FLJ45840	DEG_SPOP_SBC_1	16:20	VQSSS	SPOP	0.8662	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons