DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
VQSSS
Uniprot ID:
Q6ZS46
Source protein:
Putative uncharacterized protein FLJ45840
Source gene:
-
Class:
DEG_SPOP_SBC_1
Location:
16:20
E3 ligase:
SPOP
DEGRON score:
0.8662
ASA_SCORE:
62.9
COIL:
0.685
CONS_SCORE:
0
DSS_SCORE:
0.3476
HELIX:
0.0368
FCONS_SCORE:
0
RIG_SCORE:
0.7275
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with - mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of VQSSS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O14917
Protocadherin-17
DEG_SPOP_SBC_1
873:877
VQSSS
SPOP
0.8664
More...
P49792
E3 SUMO-protein ligase RanBP2
DEG_SPOP_SBC_1
926:930
VQSSS
SPOP
0.9967
More...
Q6ZW76
Ankyrin repeat and SAM domain-containing protein 3
DEG_SPOP_SBC_1
348:352
VQSSS
SPOP
0.9789
More...
Q8TCU4
Alstrom syndrome protein 1
DEG_SPOP_SBC_1
759:763
VQSSS
SPOP
0.9855
More...
Q8TCU4
Alstrom syndrome protein 1
DEG_SPOP_SBC_1
1045:1049
VQSSS
SPOP
0.9519
More...
Q96QF7
Germ cell nuclear acidic protein
DEG_SPOP_SBC_1
25:29
VQSSS
SPOP
0.9667
More...
Q9H2G4
Testis-specific Y-encoded-like protein 2
DEG_SPOP_SBC_1
135:139
VQSSS
SPOP
0.7915
More...
Q9NWH9
SAFB-like transcription modulator
DEG_SPOP_SBC_1
785:789
VQSSS
SPOP
0.9787
More...
Q9NYQ7
Cadherin EGF LAG seven-pass G-type receptor 3
DEG_SPOP_SBC_1
3261:3265
VQSSS
SPOP
0.715
More...
Q9UKI8
Serine/threonine-protein kinase tousled-like 1
DEG_SPOP_SBC_1
3:7
VQSSS
SPOP
0.6227
More...
Q9Y613
FH1/FH2 domain-containing protein 1
DEG_SPOP_SBC_1
1074:1078
VQSSS
SPOP
0.7081
More...
Q8WUF8
Cotranscriptional regulator FAM172A
DEG_SPOP_SBC_1
213:217
VQSSS
SPOP
0.9808
More...
Q2KHR3
Glutamine and serine-rich protein 1
DEG_SPOP_SBC_1
519:523
VQSSS
SPOP
0.9359
More...
Q6ZS46
Putative uncharacterized protein FLJ45840
DEG_SPOP_SBC_1
16:20
VQSSS
SPOP
0.8662
More...