DegronMD

Uniprot ID: Q9H2G4

Source protein: Testis-specific Y-encoded-like protein 2

Source gene: TSPYL2

Class: DEG_SPOP_SBC_1

Location: 135:139

E3 ligase: SPOP

DEGRON score: 0.7915

ASA_SCORE: 74.74

COIL: 0.6676

CONS_SCORE: 0.2323

DSS_SCORE: 0.4036

HELIX: 0.1684

FCONS_SCORE: 0.9854

RIG_SCORE: 0.7454

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E129K	TCGA-GF-A6C8	SKCM	TCGA	VQSSS	DEG_SPOP_SBC_1	0.1667
p.E129K	DO48765	SKCM	ICGC	VQSSS	DEG_SPOP_SBC_1	0.1667
p.A145S	DO229029	LICA	ICGC	VQSSS	DEG_SPOP_SBC_1	0.1667
p.A145T	DO45299	LIRI	ICGC	VQSSS	DEG_SPOP_SBC_1	0.1667
p.G125V	SIDM00545	Melanoma	GDSC	VQSSS	DEG_SPOP_SBC_1	0.0556
p.G125V	SIDM00915	Small Cell Lung Carcinoma	GDSC	VQSSS	DEG_SPOP_SBC_1	0.0556
p.G125V	NCI-H378	lung	COSMIC	VQSSS	DEG_SPOP_SBC_1	0.0556
p.G125V	Mewo	skin	COSMIC	VQSSS	DEG_SPOP_SBC_1	0.0556
p.T148I	SIDM01187	Breast Carcinoma	GDSC	VQSSS	DEG_SPOP_SBC_1	0.0833
p.T148I	UACC-812	breast	COSMIC	VQSSS	DEG_SPOP_SBC_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14917	Protocadherin-17	DEG_SPOP_SBC_1	873:877	VQSSS	SPOP	0.8664	More...
P49792	E3 SUMO-protein ligase RanBP2	DEG_SPOP_SBC_1	926:930	VQSSS	SPOP	0.9967	More...
Q6ZW76	Ankyrin repeat and SAM domain-containing protein 3	DEG_SPOP_SBC_1	348:352	VQSSS	SPOP	0.9789	More...
Q8TCU4	Alstrom syndrome protein 1	DEG_SPOP_SBC_1	759:763	VQSSS	SPOP	0.9855	More...
Q8TCU4	Alstrom syndrome protein 1	DEG_SPOP_SBC_1	1045:1049	VQSSS	SPOP	0.9519	More...
Q96QF7	Germ cell nuclear acidic protein	DEG_SPOP_SBC_1	25:29	VQSSS	SPOP	0.9667	More...
Q9H2G4	Testis-specific Y-encoded-like protein 2	DEG_SPOP_SBC_1	135:139	VQSSS	SPOP	0.7915	More...
Q9NWH9	SAFB-like transcription modulator	DEG_SPOP_SBC_1	785:789	VQSSS	SPOP	0.9787	More...
Q9NYQ7	Cadherin EGF LAG seven-pass G-type receptor 3	DEG_SPOP_SBC_1	3261:3265	VQSSS	SPOP	0.715	More...
Q9UKI8	Serine/threonine-protein kinase tousled-like 1	DEG_SPOP_SBC_1	3:7	VQSSS	SPOP	0.6227	More...
Q9Y613	FH1/FH2 domain-containing protein 1	DEG_SPOP_SBC_1	1074:1078	VQSSS	SPOP	0.7081	More...
Q8WUF8	Cotranscriptional regulator FAM172A	DEG_SPOP_SBC_1	213:217	VQSSS	SPOP	0.9808	More...
Q2KHR3	Glutamine and serine-rich protein 1	DEG_SPOP_SBC_1	519:523	VQSSS	SPOP	0.9359	More...
Q6ZS46	Putative uncharacterized protein FLJ45840	DEG_SPOP_SBC_1	16:20	VQSSS	SPOP	0.8662	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons