DegronMD - Q9NYQ7(CELSR3)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R3078L	TCGA-09-2044	OV	TCGA	SREQLDLLL	DEG_APCC_DBOX_1	3068:3076	Mutation rewiring degron network	0.2778
p.R3078L	DO28923	OV	ICGC	SREQLDLLL	DEG_APCC_DBOX_1	3068:3076	Mutation rewiring degron network	0.2778
p.A3251P	TCGA-43-5668	LUSC	TCGA	VQSSS	DEG_SPOP_SBC_1	3261:3265	Mutation rewiring degron network	0.0556
p.A3251P	DO26608	LUSC	ICGC	VQSSS	DEG_SPOP_SBC_1	3261:3265	Mutation rewiring degron network	0.0556
p.S3264L	TCGA-44-3396	LUAD	TCGA	VQSSS	DEG_SPOP_SBC_1	3261:3265	Mutation altering degron motif	0.7667
p.S3264L	DO23559	LUAD	ICGC	VQSSS	DEG_SPOP_SBC_1	3261:3265	Mutation altering degron motif	0.7667
p.S3209N	TCGA-85-8481	LUSC	TCGA	SREQLDQVP	DEG_APCC_DBOX_1	3200:3208	Mutation blocking phosphorylation signal	0.75
p.S3209N	TCGA-85-8481	LUSC	TCGA	SREALGPLP	DEG_APCC_DBOX_1	3213:3221	Mutation blocking phosphorylation signal	0.6667
p.R3077Q	TCGA-AA-A022	COAD	TCGA	SREQLDLLL	DEG_APCC_DBOX_1	3068:3076	Mutation rewiring degron network	0.3056
p.R3077Q	SIDM00060	Ovarian Carcinoma	GDSC	SREQLDLLL	DEG_APCC_DBOX_1	3068:3076	Mutation rewiring degron network	0.3056
p.R2468C	TCGA-B5-A1MR	UCEC	TCGA	GRNFLRGIL	DEG_APCC_DBOX_1	2451:2459	Mutation rewiring degron network	0.0833
p.R2468C	TCGA-F5-6814	READ	TCGA	GRNFLRGIL	DEG_APCC_DBOX_1	2451:2459	Mutation rewiring degron network	0.0833
p.P3159L	TCGA-BA-A4IH	HNSC	TCGA	PREWLSTLP	DEG_APCC_DBOX_1	3149:3157	Mutation rewiring degron network	0.2778
p.E3202K	TCGA-EE-A182	SKCM	TCGA	SREQLDQVP	DEG_APCC_DBOX_1	3200:3208	Mutation altering degron motif	0.591
p.E3202K	DO37814	SKCM	ICGC	SREQLDQVP	DEG_APCC_DBOX_1	3200:3208	Mutation altering degron motif	0.591
p.R3078W	TCGA-EJ-5525	PRAD	TCGA	SREQLDLLL	DEG_APCC_DBOX_1	3068:3076	Mutation rewiring degron network	0.2778
p.T3155M	TCGA-FI-A2D5	UCEC	TCGA	PREWLSTLP	DEG_APCC_DBOX_1	3149:3157	Mutation altering degron motif	0.6312
p.S2382G	TCGA-FJ-A3ZE	BLCA	TCGA	PTSSS	DEG_SPOP_SBC_1	2379:2383	Mutation altering degron motif	0.6993
p.S2382G	DO484	BLCA	ICGC	PTSSS	DEG_SPOP_SBC_1	2379:2383	Mutation altering degron motif	0.6993
p.R3078Q	TCGA-GN-A269	SKCM	TCGA	SREQLDLLL	DEG_APCC_DBOX_1	3068:3076	Mutation rewiring degron network	0.2778
p.R3210Q	TCGA-GS-A9TQ	DLBC	TCGA	SREQLDQVP	DEG_APCC_DBOX_1	3200:3208	Mutation rewiring degron network	0.2778
p.R3210Q	TCGA-GS-A9TQ	DLBC	TCGA	SREALGPLP	DEG_APCC_DBOX_1	3213:3221	Mutation rewiring degron network	0.25
p.R3210Q	DO219911	DLBC	ICGC	SREQLDQVP	DEG_APCC_DBOX_1	3200:3208	Mutation rewiring degron network	0.2778
p.R3210Q	DO219911	DLBC	ICGC	SREALGPLP	DEG_APCC_DBOX_1	3213:3221	Mutation rewiring degron network	0.25
p.R3210W	TCGA-IB-A5SO	PAAD	TCGA	SREQLDQVP	DEG_APCC_DBOX_1	3200:3208	Mutation rewiring degron network	0.2778
p.R3210W	TCGA-IB-A5SO	PAAD	TCGA	SREALGPLP	DEG_APCC_DBOX_1	3213:3221	Mutation rewiring degron network	0.25
p.R3210W	DO46625	PAAD	ICGC	SREQLDQVP	DEG_APCC_DBOX_1	3200:3208	Mutation rewiring degron network	0.2778
p.R3210W	DO46625	PAAD	ICGC	SREALGPLP	DEG_APCC_DBOX_1	3213:3221	Mutation rewiring degron network	0.25
p.S3230L	TCGA-UC-A7PI	CESC	TCGA	SREALGPLP	DEG_APCC_DBOX_1	3213:3221	Mutation rewiring degron network	0.0833
p.S3230L	DO51616	CESC	ICGC	SREALGPLP	DEG_APCC_DBOX_1	3213:3221	Mutation rewiring degron network	0.0833
p.V2446M	TCGA-XK-AAIW	PRAD	TCGA	GRNFLRGIL	DEG_APCC_DBOX_1	2451:2459	Mutation rewiring degron network	0.1944
p.V2446M	DO51407	PRAD	ICGC	GRNFLRGIL	DEG_APCC_DBOX_1	2451:2459	Mutation rewiring degron network	0.1944
p.S3200C	TCGA-YC-A89H	BLCA	TCGA	SREQLDQVP	DEG_APCC_DBOX_1	3200:3208	Mutation altering degron motif	0.643
p.S3200C	DO51948	BLCA	ICGC	SREQLDQVP	DEG_APCC_DBOX_1	3200:3208	Mutation altering degron motif	0.643
p.R3155Q	DO2712	BRCA	ICGC	PREWLSTLP	DEG_APCC_DBOX_1	3149:3157	Mutation altering degron motif	0.7329
p.P3190L	DO223424	CLLE	ICGC	SREQLDQVP	DEG_APCC_DBOX_1	3200:3208	Mutation rewiring degron network	0.0556
p.P3190L	SIDM01125	Non-Small Cell Lung Carcinoma	GDSC	SREQLDQVP	DEG_APCC_DBOX_1	3200:3208	Mutation rewiring degron network	0.0556
p.P3190L	ACH-000378	Lung Cancer	CCLE	SREQLDQVP	DEG_APCC_DBOX_1	3200:3208	Mutation rewiring degron network	0.0556
p.P3190L	NCI-H647	lung	COSMIC	SREQLDQVP	DEG_APCC_DBOX_1	3200:3208	Mutation rewiring degron network	0.0556
p.R3082Q	DO10647	COAD	ICGC	SREQLDLLL	DEG_APCC_DBOX_1	3068:3076	Mutation rewiring degron network	0.1667
p.R3082Q	DO35442	PACA	ICGC	SREQLDLLL	DEG_APCC_DBOX_1	3068:3076	Mutation rewiring degron network	0.1667
p.R3165C	DO230323	COCA	ICGC	PREWLSTLP	DEG_APCC_DBOX_1	3149:3157	Mutation rewiring degron network	0.1111
p.P3158L	DO230334	COCA	ICGC	PREWLSTLP	DEG_APCC_DBOX_1	3149:3157	Mutation rewiring degron network	0.3056
p.P3158L	SIDM00837	Colorectal Carcinoma	GDSC	PREWLSTLP	DEG_APCC_DBOX_1	3149:3157	Mutation rewiring degron network	0.3056
p.P3158L	ACH-000958	Colon/Colorectal Cancer	CCLE	PREWLSTLP	DEG_APCC_DBOX_1	3149:3157	Mutation rewiring degron network	0.3056
p.P3158L	SW48	large intestine	COSMIC	PREWLSTLP	DEG_APCC_DBOX_1	3149:3157	Mutation rewiring degron network	0.3056
p.G3144W	DO227984	COCA	ICGC	PREWLSTLP	DEG_APCC_DBOX_1	3149:3157	Mutation rewiring degron network	0.1944
p.P2462S	DO227987	COCA	ICGC	GRNFLRGIL	DEG_APCC_DBOX_1	2451:2459	Mutation rewiring degron network	0.25
p.T3160M	DO234219	ESAD	ICGC	PREWLSTLP	DEG_APCC_DBOX_1	3149:3157	Mutation rewiring degron network	0.25
p.T3160M	DO233879	GACA	ICGC	PREWLSTLP	DEG_APCC_DBOX_1	3149:3157	Mutation rewiring degron network	0.25
p.T3160M	DO41331	UCEC	ICGC	PREWLSTLP	DEG_APCC_DBOX_1	3149:3157	Mutation rewiring degron network	0.25
p.P2447S	DO234162	ESAD	ICGC	GRNFLRGIL	DEG_APCC_DBOX_1	2451:2459	Mutation rewiring degron network	0.2222
p.L3144P	DO234333	ESAD	ICGC	PREWLSTLP	DEG_APCC_DBOX_1	3149:3157	Mutation rewiring degron network	0.1944
p.A3068V	DO228627	GACA	ICGC	SREQLDLLL	DEG_APCC_DBOX_1	3068:3076	Mutation altering degron motif	0.6936
p.M3139V	DO228732	GACA	ICGC	PREWLSTLP	DEG_APCC_DBOX_1	3149:3157	Mutation rewiring degron network	0.0556
p.P3164L	DO52029	HNSC	ICGC	PREWLSTLP	DEG_APCC_DBOX_1	3149:3157	Mutation rewiring degron network	0.1389
p.S2386R	DO229018	LICA	ICGC	PTSSS	DEG_SPOP_SBC_1	2379:2383	Mutation rewiring degron network	0.25
p.P3221Q	DO229026	LICA	ICGC	SREALGPLP	DEG_APCC_DBOX_1	3213:3221	Mutation altering degron motif	0.5924
p.R3083W	DO229053	LICA	ICGC	SREQLDLLL	DEG_APCC_DBOX_1	3068:3076	Mutation rewiring degron network	0.1389
p.R3083W	DO36340	PRAD	ICGC	SREQLDLLL	DEG_APCC_DBOX_1	3068:3076	Mutation rewiring degron network	0.1389
p.S3214N	DO45465	LUSC	ICGC	SREALGPLP	DEG_APCC_DBOX_1	3213:3221	Mutation altering degron motif	0.7069
p.E2466K	DO220884	MELA	ICGC	GRNFLRGIL	DEG_APCC_DBOX_1	2451:2459	Mutation rewiring degron network	0.1389
p.S2372F	DO220913	MELA	ICGC	PTSSS	DEG_SPOP_SBC_1	2379:2383	Mutation rewiring degron network	0.1389
p.D3147N	DO222702	MELA	ICGC	PREWLSTLP	DEG_APCC_DBOX_1	3149:3157	Mutation rewiring degron network	0.2778
p.A3140D	DO46657	PAAD	ICGC	PREWLSTLP	DEG_APCC_DBOX_1	3149:3157	Mutation blocking phosphorylation signal	0.5278
p.R3142C	DO219987	SARC	ICGC	PREWLSTLP	DEG_APCC_DBOX_1	3149:3157	Mutation rewiring degron network	0.1389
p.R3142C	DO42633	UCEC	ICGC	PREWLSTLP	DEG_APCC_DBOX_1	3149:3157	Mutation rewiring degron network	0.1389
p.P2442L	DO47276	SKCM	ICGC	GRNFLRGIL	DEG_APCC_DBOX_1	2451:2459	Mutation rewiring degron network	0.0833
p.R3083Q	DO37483	SKCM	ICGC	SREQLDLLL	DEG_APCC_DBOX_1	3068:3076	Mutation rewiring degron network	0.1389
p.G3059V	DO47735	STAD	ICGC	SREQLDLLL	DEG_APCC_DBOX_1	3068:3076	Mutation rewiring degron network	0.0833
p.M2444I	DO40837	UCEC	ICGC	GRNFLRGIL	DEG_APCC_DBOX_1	2451:2459	Mutation rewiring degron network	0.1389
p.T3061M	DO40889	UCEC	ICGC	SREQLDLLL	DEG_APCC_DBOX_1	3068:3076	Mutation rewiring degron network	0.1389
p.A3140V	DO43306	UCEC	ICGC	PREWLSTLP	DEG_APCC_DBOX_1	3149:3157	Mutation blocking phosphorylation signal	0.5278
p.V2392A	DO42673	UCEC	ICGC	PTSSS	DEG_SPOP_SBC_1	2379:2383	Mutation rewiring degron network	0.0833
p.R3160C	SIDM01037	Breast Carcinoma	GDSC	PREWLSTLP	DEG_APCC_DBOX_1	3149:3157	Mutation rewiring degron network	0.25
p.R3160C	JIMT-1	breast	COSMIC	PREWLSTLP	DEG_APCC_DBOX_1	3149:3157	Mutation rewiring degron network	0.25
p.R3201Q	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	SREQLDQVP	DEG_APCC_DBOX_1	3200:3208	Mutation altering degron motif	0.7329
p.R3201Q	SIDM00855	Other Sarcomas	GDSC	SREQLDQVP	DEG_APCC_DBOX_1	3200:3208	Mutation altering degron motif	0.7329
p.R3201Q	SIDM00309	Mesothelioma	GDSC	SREQLDQVP	DEG_APCC_DBOX_1	3200:3208	Mutation altering degron motif	0.7329
p.R3201Q	SIDM00721	Small Cell Lung Carcinoma	GDSC	SREQLDQVP	DEG_APCC_DBOX_1	3200:3208	Mutation altering degron motif	0.7329
p.R3201Q	SIDM01605	Non-Small Cell Lung Carcinoma	GDSC	SREQLDQVP	DEG_APCC_DBOX_1	3200:3208	Mutation altering degron motif	0.7329
p.R3201Q	SIDM01387	Small Cell Lung Carcinoma	GDSC	SREQLDQVP	DEG_APCC_DBOX_1	3200:3208	Mutation altering degron motif	0.7329
p.T3162N	SIDM00845	Burkitt's Lymphoma	GDSC	PREWLSTLP	DEG_APCC_DBOX_1	3149:3157	Mutation rewiring degron network	0.1944
p.S2464N	SIDM00447	B-Lymphoblastic Leukemia	GDSC	GRNFLRGIL	DEG_APCC_DBOX_1	2451:2459	Mutation rewiring degron network	0.1944
p.S2464N	ACH-000960	Leukemia	CCLE	GRNFLRGIL	DEG_APCC_DBOX_1	2451:2459	Mutation rewiring degron network	0.1944
p.S2464N	REH	haematopoietic and lymphoid tissue	COSMIC	GRNFLRGIL	DEG_APCC_DBOX_1	2451:2459	Mutation rewiring degron network	0.1944
p.G2451R	SIDM00487	Colorectal Carcinoma	GDSC	GRNFLRGIL	DEG_APCC_DBOX_1	2451:2459	Mutation altering degron motif	0.6457
p.R2371W	SIDM00217	Colorectal Carcinoma	GDSC	PTSSS	DEG_SPOP_SBC_1	2379:2383	Mutation rewiring degron network	0.1111
p.R2371W	ACH-000999	Colon/Colorectal Cancer	CCLE	PTSSS	DEG_SPOP_SBC_1	2379:2383	Mutation rewiring degron network	0.1111
p.R2371W	SNU-1040	large intestine	COSMIC	PTSSS	DEG_SPOP_SBC_1	2379:2383	Mutation rewiring degron network	0.1111
p.R3163Q	SIDM00688	B-Cell Non-Hodgkin's Lymphoma	GDSC	PREWLSTLP	DEG_APCC_DBOX_1	3149:3157	Mutation rewiring degron network	0.1667
p.R3163Q	JSC-1	haematopoietic and lymphoid tissue	COSMIC	PREWLSTLP	DEG_APCC_DBOX_1	3149:3157	Mutation rewiring degron network	0.1667
p.R3214G	SIDM01525	Acute Myeloid Leukemia	GDSC	SREALGPLP	DEG_APCC_DBOX_1	3213:3221	Mutation altering degron motif	0.7568
p.R3214G	ACH-000557	Leukemia	CCLE	SREALGPLP	DEG_APCC_DBOX_1	3213:3221	Mutation altering degron motif	0.7568
p.R3163W	ACH-000055	Brain Cancer	CCLE	PREWLSTLP	DEG_APCC_DBOX_1	3149:3157	Mutation rewiring degron network	0.1667
p.R3161H	ACH-000513	Kidney Cancer	CCLE	PREWLSTLP	DEG_APCC_DBOX_1	3149:3157	Mutation rewiring degron network	0.2222
p.R3069G	ACH-000836	Head and Neck Cancer	CCLE	SREQLDLLL	DEG_APCC_DBOX_1	3068:3076	Mutation altering degron motif	0.7568
p.R2452H	ACH-001303	Neuroblastoma	CCLE	GRNFLRGIL	DEG_APCC_DBOX_1	2451:2459	Mutation altering degron motif	0.8244
p.L3191P	ACH-001610	Brain Cancer	CCLE	SREQLDQVP	DEG_APCC_DBOX_1	3200:3208	Mutation rewiring degron network	0.0833
p.R3082C	ACH-001818	Bone Cancer	CCLE	SREQLDLLL	DEG_APCC_DBOX_1	3068:3076	Mutation rewiring degron network	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CELSR3

UniProt ID: Q9NYQ7

Entrez ID: 1951

Protein name: Cadherin EGF LAG seven-pass G-type receptor 3 (Cadherin family member 11) (Epidermal growth factor-like protein 1) (EGF-like protein 1) (Flamingo homolog 1) (hFmi1) (Multiple epidermal growth factor-like domains protein 2) (Multiple EGF-like domains protein 2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CELSR3 in