DegronMD

Uniprot ID: Q9NYQ7

Source protein: Cadherin EGF LAG seven-pass G-type receptor 3

Source gene: CELSR3

Class: DEG_APCC_DBOX_1

Location: 3213:3221

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9991

ASA_SCORE: 72.9333

COIL: 0.704

CONS_SCORE: 0.3289

DSS_SCORE: 0.6874

HELIX: 0.271

FCONS_SCORE: 1.1121

RIG_SCORE: 0.6248

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S3209N	TCGA-85-8481	LUSC	TCGA	SREALGPLP	DEG_APCC_DBOX_1	0.6667
p.R3210Q	TCGA-GS-A9TQ	DLBC	TCGA	SREALGPLP	DEG_APCC_DBOX_1	0.25
p.R3210Q	DO219911	DLBC	ICGC	SREALGPLP	DEG_APCC_DBOX_1	0.25
p.R3210W	TCGA-IB-A5SO	PAAD	TCGA	SREALGPLP	DEG_APCC_DBOX_1	0.25
p.R3210W	DO46625	PAAD	ICGC	SREALGPLP	DEG_APCC_DBOX_1	0.25
p.S3230L	TCGA-UC-A7PI	CESC	TCGA	SREALGPLP	DEG_APCC_DBOX_1	0.0833
p.S3230L	DO51616	CESC	ICGC	SREALGPLP	DEG_APCC_DBOX_1	0.0833
p.P3221Q	DO229026	LICA	ICGC	SREALGPLP	DEG_APCC_DBOX_1	0.5924
p.S3214N	DO45465	LUSC	ICGC	SREALGPLP	DEG_APCC_DBOX_1	0.7069
p.R3214G	SIDM01525	Acute Myeloid Leukemia	GDSC	SREALGPLP	DEG_APCC_DBOX_1	0.7568
p.R3214G	ACH-000557	Leukemia	CCLE	SREALGPLP	DEG_APCC_DBOX_1	0.7568

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NYQ7	Cadherin EGF LAG seven-pass G-type receptor 3	DEG_APCC_DBOX_1	3213:3221	SREALGPLP	APC,CDC20,FZR1	0.9991	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons