DegronMD

Uniprot ID: Q9NYQ7

Source protein: Cadherin EGF LAG seven-pass G-type receptor 3

Source gene: CELSR3

Class: DEG_APCC_DBOX_1

Location: 2451:2459

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.559

ASA_SCORE: 82.9333

COIL: 0.6986

CONS_SCORE: 0.297

DSS_SCORE: 0.0553

HELIX: 0.0454

FCONS_SCORE: 0.8113

RIG_SCORE: 0.8297

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R2468C	TCGA-B5-A1MR	UCEC	TCGA	GRNFLRGIL	DEG_APCC_DBOX_1	0.0833
p.R2468C	TCGA-F5-6814	READ	TCGA	GRNFLRGIL	DEG_APCC_DBOX_1	0.0833
p.V2446M	TCGA-XK-AAIW	PRAD	TCGA	GRNFLRGIL	DEG_APCC_DBOX_1	0.1944
p.V2446M	DO51407	PRAD	ICGC	GRNFLRGIL	DEG_APCC_DBOX_1	0.1944
p.P2462S	DO227987	COCA	ICGC	GRNFLRGIL	DEG_APCC_DBOX_1	0.25
p.P2447S	DO234162	ESAD	ICGC	GRNFLRGIL	DEG_APCC_DBOX_1	0.2222
p.E2466K	DO220884	MELA	ICGC	GRNFLRGIL	DEG_APCC_DBOX_1	0.1389
p.P2442L	DO47276	SKCM	ICGC	GRNFLRGIL	DEG_APCC_DBOX_1	0.0833
p.M2444I	DO40837	UCEC	ICGC	GRNFLRGIL	DEG_APCC_DBOX_1	0.1389
p.S2464N	SIDM00447	B-Lymphoblastic Leukemia	GDSC	GRNFLRGIL	DEG_APCC_DBOX_1	0.1944
p.S2464N	ACH-000960	Leukemia	CCLE	GRNFLRGIL	DEG_APCC_DBOX_1	0.1944
p.S2464N	REH	haematopoietic_and_lymphoid_tissue	COSMIC	GRNFLRGIL	DEG_APCC_DBOX_1	0.1944
p.G2451R	SIDM00487	Colorectal Carcinoma	GDSC	GRNFLRGIL	DEG_APCC_DBOX_1	0.6457
p.R2452H	ACH-001303	Neuroblastoma	CCLE	GRNFLRGIL	DEG_APCC_DBOX_1	0.8244

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NYQ7	Cadherin EGF LAG seven-pass G-type receptor 3	DEG_APCC_DBOX_1	2451:2459	GRNFLRGIL	APC,CDC20,FZR1	0.559	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons