DegronMD

Uniprot ID: Q9NYQ7

Source protein: Cadherin EGF LAG seven-pass G-type receptor 3

Source gene: CELSR3

Class: DEG_APCC_DBOX_1

Location: 3149:3157

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.702

ASA_SCORE: 67.1

COIL: 0.602

CONS_SCORE: 0.1732

DSS_SCORE: 0.631

HELIX: 0.3551

FCONS_SCORE: 0.9662

RIG_SCORE: 0.6815

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P3159L	TCGA-BA-A4IH	HNSC	TCGA	PREWLSTLP	DEG_APCC_DBOX_1	0.2778
p.T3155M	TCGA-FI-A2D5	UCEC	TCGA	PREWLSTLP	DEG_APCC_DBOX_1	0.6312
p.R3155Q	DO2712	BRCA	ICGC	PREWLSTLP	DEG_APCC_DBOX_1	0.7329
p.R3165C	DO230323	COCA	ICGC	PREWLSTLP	DEG_APCC_DBOX_1	0.1111
p.P3158L	DO230334	COCA	ICGC	PREWLSTLP	DEG_APCC_DBOX_1	0.3056
p.P3158L	SIDM00837	Colorectal Carcinoma	GDSC	PREWLSTLP	DEG_APCC_DBOX_1	0.3056
p.P3158L	ACH-000958	Colon/Colorectal Cancer	CCLE	PREWLSTLP	DEG_APCC_DBOX_1	0.3056
p.P3158L	SW48	large_intestine	COSMIC	PREWLSTLP	DEG_APCC_DBOX_1	0.3056
p.G3144W	DO227984	COCA	ICGC	PREWLSTLP	DEG_APCC_DBOX_1	0.1944
p.T3160M	DO234219	ESAD	ICGC	PREWLSTLP	DEG_APCC_DBOX_1	0.25
p.T3160M	DO233879	GACA	ICGC	PREWLSTLP	DEG_APCC_DBOX_1	0.25
p.T3160M	DO41331	UCEC	ICGC	PREWLSTLP	DEG_APCC_DBOX_1	0.25
p.L3144P	DO234333	ESAD	ICGC	PREWLSTLP	DEG_APCC_DBOX_1	0.1944
p.M3139V	DO228732	GACA	ICGC	PREWLSTLP	DEG_APCC_DBOX_1	0.0556
p.P3164L	DO52029	HNSC	ICGC	PREWLSTLP	DEG_APCC_DBOX_1	0.1389
p.D3147N	DO222702	MELA	ICGC	PREWLSTLP	DEG_APCC_DBOX_1	0.2778
p.A3140D	DO46657	PAAD	ICGC	PREWLSTLP	DEG_APCC_DBOX_1	0.5278
p.R3142C	DO219987	SARC	ICGC	PREWLSTLP	DEG_APCC_DBOX_1	0.1389
p.R3142C	DO42633	UCEC	ICGC	PREWLSTLP	DEG_APCC_DBOX_1	0.1389
p.A3140V	DO43306	UCEC	ICGC	PREWLSTLP	DEG_APCC_DBOX_1	0.5278
p.R3160C	SIDM01037	Breast Carcinoma	GDSC	PREWLSTLP	DEG_APCC_DBOX_1	0.25
p.R3160C	JIMT-1	breast	COSMIC	PREWLSTLP	DEG_APCC_DBOX_1	0.25
p.T3162N	SIDM00845	Burkitt's Lymphoma	GDSC	PREWLSTLP	DEG_APCC_DBOX_1	0.1944
p.R3163Q	SIDM00688	B-Cell Non-Hodgkin's Lymphoma	GDSC	PREWLSTLP	DEG_APCC_DBOX_1	0.1667
p.R3163Q	JSC-1	haematopoietic_and_lymphoid_tissue	COSMIC	PREWLSTLP	DEG_APCC_DBOX_1	0.1667
p.R3163W	ACH-000055	Brain Cancer	CCLE	PREWLSTLP	DEG_APCC_DBOX_1	0.1667
p.R3161H	ACH-000513	Kidney Cancer	CCLE	PREWLSTLP	DEG_APCC_DBOX_1	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PREWLSTLP

Degron related mutations and impact score

Drug responses associated with CELSR3 mutations

All proteins holding degron of PREWLSTLP

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NYQ7	Cadherin EGF LAG seven-pass G-type receptor 3	DEG_APCC_DBOX_1	3149:3157	PREWLSTLP	APC,CDC20,FZR1	0.702	More...