DegronMD

Uniprot ID: Q9NYQ7

Source protein: Cadherin EGF LAG seven-pass G-type receptor 3

Source gene: CELSR3

Class: DEG_APCC_DBOX_1

Location: 3068:3076

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5125

ASA_SCORE: 72.1556

COIL: 0.1479

CONS_SCORE: 0.2114

DSS_SCORE: 0.4143

HELIX: 0.8577

FCONS_SCORE: 0.8739

RIG_SCORE: 0.7925

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R3078L	TCGA-09-2044	OV	TCGA	SREQLDLLL	DEG_APCC_DBOX_1	0.2778
p.R3078L	DO28923	OV	ICGC	SREQLDLLL	DEG_APCC_DBOX_1	0.2778
p.R3077Q	TCGA-AA-A022	COAD	TCGA	SREQLDLLL	DEG_APCC_DBOX_1	0.3056
p.R3077Q	SIDM00060	Ovarian Carcinoma	GDSC	SREQLDLLL	DEG_APCC_DBOX_1	0.3056
p.R3078W	TCGA-EJ-5525	PRAD	TCGA	SREQLDLLL	DEG_APCC_DBOX_1	0.2778
p.R3078Q	TCGA-GN-A269	SKCM	TCGA	SREQLDLLL	DEG_APCC_DBOX_1	0.2778
p.R3082Q	DO10647	COAD	ICGC	SREQLDLLL	DEG_APCC_DBOX_1	0.1667
p.R3082Q	DO35442	PACA	ICGC	SREQLDLLL	DEG_APCC_DBOX_1	0.1667
p.A3068V	DO228627	GACA	ICGC	SREQLDLLL	DEG_APCC_DBOX_1	0.6936
p.R3083W	DO229053	LICA	ICGC	SREQLDLLL	DEG_APCC_DBOX_1	0.1389
p.R3083W	DO36340	PRAD	ICGC	SREQLDLLL	DEG_APCC_DBOX_1	0.1389
p.R3083Q	DO37483	SKCM	ICGC	SREQLDLLL	DEG_APCC_DBOX_1	0.1389
p.G3059V	DO47735	STAD	ICGC	SREQLDLLL	DEG_APCC_DBOX_1	0.0833
p.T3061M	DO40889	UCEC	ICGC	SREQLDLLL	DEG_APCC_DBOX_1	0.1389
p.R3069G	ACH-000836	Head and Neck Cancer	CCLE	SREQLDLLL	DEG_APCC_DBOX_1	0.7568
p.R3082C	ACH-001818	Bone Cancer	CCLE	SREQLDLLL	DEG_APCC_DBOX_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NYQ7	Cadherin EGF LAG seven-pass G-type receptor 3	DEG_APCC_DBOX_1	3068:3076	SREQLDLLL	APC,CDC20,FZR1	0.5125	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons