DegronMD

Uniprot ID: Q9NYQ7

Source protein: Cadherin EGF LAG seven-pass G-type receptor 3

Source gene: CELSR3

Class: DEG_APCC_DBOX_1

Location: 3200:3208

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9718

ASA_SCORE: 76.2333

COIL: 0.7231

CONS_SCORE: 0.3357

DSS_SCORE: 0.7556

HELIX: 0.2244

FCONS_SCORE: 1.0252

RIG_SCORE: 0.5806

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S3209N	TCGA-85-8481	LUSC	TCGA	SREQLDQVP	DEG_APCC_DBOX_1	0.75
p.E3202K	TCGA-EE-A182	SKCM	TCGA	SREQLDQVP	DEG_APCC_DBOX_1	0.591
p.E3202K	DO37814	SKCM	ICGC	SREQLDQVP	DEG_APCC_DBOX_1	0.591
p.R3210Q	TCGA-GS-A9TQ	DLBC	TCGA	SREQLDQVP	DEG_APCC_DBOX_1	0.2778
p.R3210Q	DO219911	DLBC	ICGC	SREQLDQVP	DEG_APCC_DBOX_1	0.2778
p.R3210W	TCGA-IB-A5SO	PAAD	TCGA	SREQLDQVP	DEG_APCC_DBOX_1	0.2778
p.R3210W	DO46625	PAAD	ICGC	SREQLDQVP	DEG_APCC_DBOX_1	0.2778
p.S3200C	TCGA-YC-A89H	BLCA	TCGA	SREQLDQVP	DEG_APCC_DBOX_1	0.643
p.S3200C	DO51948	BLCA	ICGC	SREQLDQVP	DEG_APCC_DBOX_1	0.643
p.P3190L	DO223424	CLLE	ICGC	SREQLDQVP	DEG_APCC_DBOX_1	0.0556
p.P3190L	SIDM01125	Non-Small Cell Lung Carcinoma	GDSC	SREQLDQVP	DEG_APCC_DBOX_1	0.0556
p.P3190L	ACH-000378	Lung Cancer	CCLE	SREQLDQVP	DEG_APCC_DBOX_1	0.0556
p.P3190L	NCI-H647	lung	COSMIC	SREQLDQVP	DEG_APCC_DBOX_1	0.0556
p.R3201Q	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	SREQLDQVP	DEG_APCC_DBOX_1	0.7329
p.R3201Q	SIDM00855	Other Sarcomas	GDSC	SREQLDQVP	DEG_APCC_DBOX_1	0.7329
p.R3201Q	SIDM00309	Mesothelioma	GDSC	SREQLDQVP	DEG_APCC_DBOX_1	0.7329
p.R3201Q	SIDM00721	Small Cell Lung Carcinoma	GDSC	SREQLDQVP	DEG_APCC_DBOX_1	0.7329
p.R3201Q	SIDM01605	Non-Small Cell Lung Carcinoma	GDSC	SREQLDQVP	DEG_APCC_DBOX_1	0.7329
p.R3201Q	SIDM01387	Small Cell Lung Carcinoma	GDSC	SREQLDQVP	DEG_APCC_DBOX_1	0.7329
p.L3191P	ACH-001610	Brain Cancer	CCLE	SREQLDQVP	DEG_APCC_DBOX_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NYQ7	Cadherin EGF LAG seven-pass G-type receptor 3	DEG_APCC_DBOX_1	3200:3208	SREQLDQVP	APC,CDC20,FZR1	0.9718	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons