DegronMD

Uniprot ID: Q6ZW76

Source protein: Ankyrin repeat and SAM domain-containing protein 3

Source gene: ANKS3

Class: DEG_SPOP_SBC_1

Location: 348:352

E3 ligase: SPOP

DEGRON score: 0.9789

ASA_SCORE: 67.9

COIL: 0.8204

CONS_SCORE: 0.5838

DSS_SCORE: 0.5029

HELIX: 0.1124

FCONS_SCORE: 1.2021

RIG_SCORE: 0.6115

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E338V	TCGA-06-5416	GBM	TCGA	VQSSS	DEG_SPOP_SBC_1	0.0556
p.Q361H	TCGA-BF-A1PZ	SKCM	TCGA	VQSSS	DEG_SPOP_SBC_1	0.0833
p.V348I	TCGA-EO-A3B0	UCEC	TCGA	VQSSS	DEG_SPOP_SBC_1	0.7076
p.A360T	DO230343	COCA	ICGC	VQSSS	DEG_SPOP_SBC_1	0.1111
p.A360T	DO41452	UCEC	ICGC	VQSSS	DEG_SPOP_SBC_1	0.1111
p.T341K	DO229006	LICA	ICGC	VQSSS	DEG_SPOP_SBC_1	0.1389
p.A352G	DO23711	LUAD	ICGC	VQSSS	DEG_SPOP_SBC_1	0.754
p.I340L	DO51274	SKCM	ICGC	VQSSS	DEG_SPOP_SBC_1	0.1111
p.R361H	DO51776	STAD	ICGC	VQSSS	DEG_SPOP_SBC_1	0.0833
p.R361C	DO222335	STAD	ICGC	VQSSS	DEG_SPOP_SBC_1	0.0833
p.R361C	DO40996	UCEC	ICGC	VQSSS	DEG_SPOP_SBC_1	0.0833
p.V348G	SIDM01660	Kidney Carcinoma	GDSC	VQSSS	DEG_SPOP_SBC_1	0.7532
p.V348G	ACH-000709	Kidney Cancer	CCLE	VQSSS	DEG_SPOP_SBC_1	0.7532
p.F341L	SIDM01518	Oral Cavity Carcinoma	GDSC	VQSSS	DEG_SPOP_SBC_1	0.1389
p.F341L	ACH-000771	Head and Neck Cancer	CCLE	VQSSS	DEG_SPOP_SBC_1	0.1389
p.L357P	ACH-000801	Skin Cancer	CCLE	VQSSS	DEG_SPOP_SBC_1	0.1944
p.T350S	LS-180	large_intestine	COSMIC	VQSSS	DEG_SPOP_SBC_1	0.7116

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14917	Protocadherin-17	DEG_SPOP_SBC_1	873:877	VQSSS	SPOP	0.8664	More...
P49792	E3 SUMO-protein ligase RanBP2	DEG_SPOP_SBC_1	926:930	VQSSS	SPOP	0.9967	More...
Q6ZW76	Ankyrin repeat and SAM domain-containing protein 3	DEG_SPOP_SBC_1	348:352	VQSSS	SPOP	0.9789	More...
Q8TCU4	Alstrom syndrome protein 1	DEG_SPOP_SBC_1	759:763	VQSSS	SPOP	0.9855	More...
Q8TCU4	Alstrom syndrome protein 1	DEG_SPOP_SBC_1	1045:1049	VQSSS	SPOP	0.9519	More...
Q96QF7	Germ cell nuclear acidic protein	DEG_SPOP_SBC_1	25:29	VQSSS	SPOP	0.9667	More...
Q9H2G4	Testis-specific Y-encoded-like protein 2	DEG_SPOP_SBC_1	135:139	VQSSS	SPOP	0.7915	More...
Q9NWH9	SAFB-like transcription modulator	DEG_SPOP_SBC_1	785:789	VQSSS	SPOP	0.9787	More...
Q9NYQ7	Cadherin EGF LAG seven-pass G-type receptor 3	DEG_SPOP_SBC_1	3261:3265	VQSSS	SPOP	0.715	More...
Q9UKI8	Serine/threonine-protein kinase tousled-like 1	DEG_SPOP_SBC_1	3:7	VQSSS	SPOP	0.6227	More...
Q9Y613	FH1/FH2 domain-containing protein 1	DEG_SPOP_SBC_1	1074:1078	VQSSS	SPOP	0.7081	More...
Q8WUF8	Cotranscriptional regulator FAM172A	DEG_SPOP_SBC_1	213:217	VQSSS	SPOP	0.9808	More...
Q2KHR3	Glutamine and serine-rich protein 1	DEG_SPOP_SBC_1	519:523	VQSSS	SPOP	0.9359	More...
Q6ZS46	Putative uncharacterized protein FLJ45840	DEG_SPOP_SBC_1	16:20	VQSSS	SPOP	0.8662	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons