DegronMD

Uniprot ID: Q8TCU4

Source protein: Alstrom syndrome protein 1

Source gene: ALMS1

Class: DEG_SPOP_SBC_1

Location: 1045:1049

E3 ligase: SPOP

DEGRON score: 0.9519

ASA_SCORE: 85.26

COIL: 0.8748

CONS_SCORE: 0.3465

DSS_SCORE: 0.6427

HELIX: 0.0264

FCONS_SCORE: 0.9384

RIG_SCORE: 0.6535

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E1040V	TCGA-43-5668	LUSC	TCGA	VQSSS	DEG_SPOP_SBC_1	0.1944
p.E1040V	DO26608	LUSC	ICGC	VQSSS	DEG_SPOP_SBC_1	0.1944
p.R1052M	TCGA-43-A56U	LUSC	TCGA	VQSSS	DEG_SPOP_SBC_1	0.25
p.R1052M	DO49083	LUSC	ICGC	VQSSS	DEG_SPOP_SBC_1	0.25
p.V1044A	TCGA-AJ-A3EL	UCEC	TCGA	VQSSS	DEG_SPOP_SBC_1	0.3056
p.V1044A	DO41542	UCEC	ICGC	VQSSS	DEG_SPOP_SBC_1	0.3056
p.E1053D	TCGA-AN-A046	BRCA	TCGA	VQSSS	DEG_SPOP_SBC_1	0.2222
p.E1053D	DO1285	BRCA	ICGC	VQSSS	DEG_SPOP_SBC_1	0.2222
p.E1053K	TCGA-B7-A5TI	STAD	TCGA	VQSSS	DEG_SPOP_SBC_1	0.2222
p.E1053K	DO222328	STAD	ICGC	VQSSS	DEG_SPOP_SBC_1	0.2222
p.V1057A	TCGA-CG-5723	STAD	TCGA	VQSSS	DEG_SPOP_SBC_1	0.1111
p.P1042Q	TCGA-EE-A2MM	SKCM	TCGA	VQSSS	DEG_SPOP_SBC_1	0.25
p.S1047I	DO228986	LICA	ICGC	VQSSS	DEG_SPOP_SBC_1	0.7341
p.V1045I	SIDM00373	Endometrial Carcinoma	GDSC	VQSSS	DEG_SPOP_SBC_1	0.7076
p.V1045I	SNG-M	endometrium	COSMIC	VQSSS	DEG_SPOP_SBC_1	0.7076
p.L1059W	SIDM00919	Ovarian Carcinoma	GDSC	VQSSS	DEG_SPOP_SBC_1	0.0556
p.L1059W	Caov-3	ovary	COSMIC	VQSSS	DEG_SPOP_SBC_1	0.0556
p.P1035Q	SIDM00257	Neuroblastoma	GDSC	VQSSS	DEG_SPOP_SBC_1	0.0556
p.P1035Q	NB13	autonomic_ganglia	COSMIC	VQSSS	DEG_SPOP_SBC_1	0.0556
p.P1035S	SIDM01758	B-Cell Non-Hodgkin's Lymphoma	GDSC	VQSSS	DEG_SPOP_SBC_1	0.0556
p.S1049A	SIDM01450	Gastric Carcinoma	GDSC	VQSSS	DEG_SPOP_SBC_1	0.7588
p.L1058W	ACH-000713	Ovarian Cancer	CCLE	VQSSS	DEG_SPOP_SBC_1	0.0833
p.S1048A	ACH-000898	Gastric Cancer	CCLE	VQSSS	DEG_SPOP_SBC_1	0.7588
p.V1044I	ACH-000974	Endometrial/Uterine Cancer	CCLE	VQSSS	DEG_SPOP_SBC_1	0.3056
p.V1044I	ACH-002026	Endometrial/Uterine Cancer	CCLE	VQSSS	DEG_SPOP_SBC_1	0.3056
p.P1038S	NCI-H1770	lung	COSMIC	VQSSS	DEG_SPOP_SBC_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14917	Protocadherin-17	DEG_SPOP_SBC_1	873:877	VQSSS	SPOP	0.8664	More...
P49792	E3 SUMO-protein ligase RanBP2	DEG_SPOP_SBC_1	926:930	VQSSS	SPOP	0.9967	More...
Q6ZW76	Ankyrin repeat and SAM domain-containing protein 3	DEG_SPOP_SBC_1	348:352	VQSSS	SPOP	0.9789	More...
Q8TCU4	Alstrom syndrome protein 1	DEG_SPOP_SBC_1	759:763	VQSSS	SPOP	0.9855	More...
Q8TCU4	Alstrom syndrome protein 1	DEG_SPOP_SBC_1	1045:1049	VQSSS	SPOP	0.9519	More...
Q96QF7	Germ cell nuclear acidic protein	DEG_SPOP_SBC_1	25:29	VQSSS	SPOP	0.9667	More...
Q9H2G4	Testis-specific Y-encoded-like protein 2	DEG_SPOP_SBC_1	135:139	VQSSS	SPOP	0.7915	More...
Q9NWH9	SAFB-like transcription modulator	DEG_SPOP_SBC_1	785:789	VQSSS	SPOP	0.9787	More...
Q9NYQ7	Cadherin EGF LAG seven-pass G-type receptor 3	DEG_SPOP_SBC_1	3261:3265	VQSSS	SPOP	0.715	More...
Q9UKI8	Serine/threonine-protein kinase tousled-like 1	DEG_SPOP_SBC_1	3:7	VQSSS	SPOP	0.6227	More...
Q9Y613	FH1/FH2 domain-containing protein 1	DEG_SPOP_SBC_1	1074:1078	VQSSS	SPOP	0.7081	More...
Q8WUF8	Cotranscriptional regulator FAM172A	DEG_SPOP_SBC_1	213:217	VQSSS	SPOP	0.9808	More...
Q2KHR3	Glutamine and serine-rich protein 1	DEG_SPOP_SBC_1	519:523	VQSSS	SPOP	0.9359	More...
Q6ZS46	Putative uncharacterized protein FLJ45840	DEG_SPOP_SBC_1	16:20	VQSSS	SPOP	0.8662	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VQSSS

Degron related mutations and impact score

Drug responses associated with ALMS1 mutations

All proteins holding degron of VQSSS