DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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CGC
Degron:
VQSSS
Uniprot ID:
Q9NWH9
Source protein:
SAFB-like transcription modulator
Source gene:
SLTM
Class:
DEG_SPOP_SBC_1
Location:
785:789
E3 ligase:
SPOP
DEGRON score:
0.9787
ASA_SCORE:
78.58
COIL:
0.7692
CONS_SCORE:
0.3635
DSS_SCORE:
0.5578
HELIX:
0.2104
FCONS_SCORE:
0.8717
RIG_SCORE:
0.6286
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.E775Q
TCGA-33-AASI
LUSC
TCGA
VQSSS
DEG_SPOP_SBC_1
0.0556
p.V797I
TCGA-AA-A01P
COAD
TCGA
VQSSS
DEG_SPOP_SBC_1
0.1111
p.R795H
TCGA-AX-A0J1
UCEC
TCGA
VQSSS
DEG_SPOP_SBC_1
0.1667
p.E775D
TCGA-AX-A2HC
UCEC
TCGA
VQSSS
DEG_SPOP_SBC_1
0.0556
p.V797D
TCGA-C4-A0F6
BLCA
TCGA
VQSSS
DEG_SPOP_SBC_1
0.1111
p.R793W
TCGA-E9-A5UO
BRCA
TCGA
VQSSS
DEG_SPOP_SBC_1
0.2222
p.E775K
TCGA-EE-A2M5
SKCM
TCGA
VQSSS
DEG_SPOP_SBC_1
0.0556
p.P780S
TCGA-EE-A2MS
SKCM
TCGA
VQSSS
DEG_SPOP_SBC_1
0.1944
p.P780S
TCGA-W3-AA1V
SKCM
TCGA
VQSSS
DEG_SPOP_SBC_1
0.1944
p.P780S
SIDM00379
Glioma
GDSC
VQSSS
DEG_SPOP_SBC_1
0.1944
p.P780S
ACH-002304
Brain Cancer
CCLE
VQSSS
DEG_SPOP_SBC_1
0.1944
p.P780S
SK-MG-1
central_nervous_system
COSMIC
VQSSS
DEG_SPOP_SBC_1
0.1944
p.V797A
TCGA-FI-A2D5
UCEC
TCGA
VQSSS
DEG_SPOP_SBC_1
0.1111
p.D794Y
TCGA-NC-A5HH
LUSC
TCGA
VQSSS
DEG_SPOP_SBC_1
0.1944
p.R795C
SIDM01134
Small Cell Lung Carcinoma
GDSC
VQSSS
DEG_SPOP_SBC_1
0.1667
p.R795C
ACH-000292
Lung Cancer
CCLE
VQSSS
DEG_SPOP_SBC_1
0.1667
Drug responses associated with SLTM mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of VQSSS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O14917
Protocadherin-17
DEG_SPOP_SBC_1
873:877
VQSSS
SPOP
0.8664
More...
P49792
E3 SUMO-protein ligase RanBP2
DEG_SPOP_SBC_1
926:930
VQSSS
SPOP
0.9967
More...
Q6ZW76
Ankyrin repeat and SAM domain-containing protein 3
DEG_SPOP_SBC_1
348:352
VQSSS
SPOP
0.9789
More...
Q8TCU4
Alstrom syndrome protein 1
DEG_SPOP_SBC_1
759:763
VQSSS
SPOP
0.9855
More...
Q8TCU4
Alstrom syndrome protein 1
DEG_SPOP_SBC_1
1045:1049
VQSSS
SPOP
0.9519
More...
Q96QF7
Germ cell nuclear acidic protein
DEG_SPOP_SBC_1
25:29
VQSSS
SPOP
0.9667
More...
Q9H2G4
Testis-specific Y-encoded-like protein 2
DEG_SPOP_SBC_1
135:139
VQSSS
SPOP
0.7915
More...
Q9NWH9
SAFB-like transcription modulator
DEG_SPOP_SBC_1
785:789
VQSSS
SPOP
0.9787
More...
Q9NYQ7
Cadherin EGF LAG seven-pass G-type receptor 3
DEG_SPOP_SBC_1
3261:3265
VQSSS
SPOP
0.715
More...
Q9UKI8
Serine/threonine-protein kinase tousled-like 1
DEG_SPOP_SBC_1
3:7
VQSSS
SPOP
0.6227
More...
Q9Y613
FH1/FH2 domain-containing protein 1
DEG_SPOP_SBC_1
1074:1078
VQSSS
SPOP
0.7081
More...
Q8WUF8
Cotranscriptional regulator FAM172A
DEG_SPOP_SBC_1
213:217
VQSSS
SPOP
0.9808
More...
Q2KHR3
Glutamine and serine-rich protein 1
DEG_SPOP_SBC_1
519:523
VQSSS
SPOP
0.9359
More...
Q6ZS46
Putative uncharacterized protein FLJ45840
DEG_SPOP_SBC_1
16:20
VQSSS
SPOP
0.8662
More...