DegronMD - Q9UKI8(TLK1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S7T	TCGA-05-4424	LUAD	TCGA	VQSSS	DEG_SPOP_SBC_1	3:7	Mutation altering degron motif	0.7116
p.S7T	DO23672	LUAD	ICGC	VQSSS	DEG_SPOP_SBC_1	3:7	Mutation altering degron motif	0.7116
p.G8E	TCGA-06-5416	GBM	TCGA	VQSSS	DEG_SPOP_SBC_1	3:7	Mutation rewiring degron network	0.3056
p.G8E	DO10880	GBM	ICGC	VQSSS	DEG_SPOP_SBC_1	3:7	Mutation rewiring degron network	0.3056
p.R384I	TCGA-21-1083	LUSC	TCGA	VRPNLPQLL	DEG_APCC_DBOX_1	383:391	Mutation altering degron motif	0.8102
p.R384I	DO26769	LUSC	ICGC	VRPNLPQLL	DEG_APCC_DBOX_1	383:391	Mutation altering degron motif	0.8102
p.H397D	TCGA-AX-A2IO	UCEC	TCGA	VRPNLPQLL	DEG_APCC_DBOX_1	383:391	Mutation rewiring degron network	0.1667
p.H397D	DO40800	UCEC	ICGC	VRPNLPQLL	DEG_APCC_DBOX_1	383:391	Mutation rewiring degron network	0.1667
p.E400G	TCGA-B5-A3FA	UCEC	TCGA	VRPNLPQLL	DEG_APCC_DBOX_1	383:391	Mutation rewiring degron network	0.0833
p.G751R	TCGA-BR-4371	STAD	TCGA	PTPPSS	DEG_SCF_FBW7_1	756:761	Mutation rewiring degron network	0.1944
p.G751R	TCGA-BR-4371	STAD	TCGA	PPSSS	DEG_SPOP_SBC_1	758:762	Mutation rewiring degron network	0.1389
p.G751R	DO38348	STAD	ICGC	PTPPSS	DEG_SCF_FBW7_1	756:761	Mutation rewiring degron network	0.1944
p.G751R	DO38348	STAD	ICGC	PPSSS	DEG_SPOP_SBC_1	758:762	Mutation rewiring degron network	0.1389
p.L747P	TCGA-CG-4305	STAD	TCGA	PTPPSS	DEG_SCF_FBW7_1	756:761	Mutation rewiring degron network	0.0833
p.L747P	DO38823	STAD	ICGC	PTPPSS	DEG_SCF_FBW7_1	756:761	Mutation rewiring degron network	0.0833
p.Q399H	TCGA-CR-7379	HNSC	TCGA	VRPNLPQLL	DEG_APCC_DBOX_1	383:391	Mutation rewiring degron network	0.1111
p.E400K	TCGA-EE-A2GC	SKCM	TCGA	VRPNLPQLL	DEG_APCC_DBOX_1	383:391	Mutation rewiring degron network	0.0833
p.E400K	DO37839	SKCM	ICGC	VRPNLPQLL	DEG_APCC_DBOX_1	383:391	Mutation rewiring degron network	0.0833
p.E400K	SIDM01068	Non-Small Cell Lung Carcinoma	GDSC	VRPNLPQLL	DEG_APCC_DBOX_1	383:391	Mutation rewiring degron network	0.0833
p.E400K	ACH-000562	Lung Cancer	CCLE	VRPNLPQLL	DEG_APCC_DBOX_1	383:391	Mutation rewiring degron network	0.0833
p.E400K	HCC-78	lung	COSMIC	VRPNLPQLL	DEG_APCC_DBOX_1	383:391	Mutation rewiring degron network	0.0833
p.S9G	TCGA-EY-A1GU	UCEC	TCGA	VQSSS	DEG_SPOP_SBC_1	3:7	Mutation rewiring degron network	0.2778
p.S9G	DO41518	UCEC	ICGC	VQSSS	DEG_SPOP_SBC_1	3:7	Mutation rewiring degron network	0.2778
p.E378Q	TCGA-GN-A8LK	SKCM	TCGA	VRPNLPQLL	DEG_APCC_DBOX_1	383:391	Mutation rewiring degron network	0.1944
p.E378Q	DO51259	SKCM	ICGC	VRPNLPQLL	DEG_APCC_DBOX_1	383:391	Mutation rewiring degron network	0.1944
p.L390V	TCGA-YL-A8SO	PRAD	TCGA	VRPNLPQLL	DEG_APCC_DBOX_1	383:391	Mutation altering degron motif	0.5654
p.S382C	DO51884	BLCA	ICGC	VRPNLPQLL	DEG_APCC_DBOX_1	383:391	Mutation rewiring degron network	0.3056
p.Q389K	DO229015	LICA	ICGC	VRPNLPQLL	DEG_APCC_DBOX_1	383:391	Mutation altering degron motif	0.5833
p.A373E	DO229036	LICA	ICGC	VRPNLPQLL	DEG_APCC_DBOX_1	383:391	Mutation rewiring degron network	0.0556
p.A373G	DO229058	LICA	ICGC	VRPNLPQLL	DEG_APCC_DBOX_1	383:391	Mutation rewiring degron network	0.0556
p.P387L	DO47795	STAD	ICGC	VRPNLPQLL	DEG_APCC_DBOX_1	383:391	Mutation altering degron motif	0.7582
p.D8G	SIDM00336	Melanoma	GDSC	VQSSS	DEG_SPOP_SBC_1	3:7	Mutation rewiring degron network	0.3056
p.D8G	MEL-JUSO	skin	COSMIC	VQSSS	DEG_SPOP_SBC_1	3:7	Mutation rewiring degron network	0.3056
p.P388L	SIDM00364	B-Lymphoblastic Leukemia	GDSC	VRPNLPQLL	DEG_APCC_DBOX_1	383:391	Mutation altering degron motif	0.6471
p.P388L	ACH-002059	Leukemia	CCLE	VRPNLPQLL	DEG_APCC_DBOX_1	383:391	Mutation altering degron motif	0.6471
p.P388L	P30-OHK	haematopoietic and lymphoid tissue	COSMIC	VRPNLPQLL	DEG_APCC_DBOX_1	383:391	Mutation altering degron motif	0.6471
p.G376E	SIDM01779	Gastric Carcinoma	GDSC	VRPNLPQLL	DEG_APCC_DBOX_1	383:391	Mutation rewiring degron network	0.1389
p.G376E	ACH-000761	Gastric Cancer	CCLE	VRPNLPQLL	DEG_APCC_DBOX_1	383:391	Mutation rewiring degron network	0.1389
p.V374I	ACH-001346	Head and Neck Cancer	CCLE	VRPNLPQLL	DEG_APCC_DBOX_1	383:391	Mutation rewiring degron network	0.0833
p.S764Y	HT-115	large intestine	COSMIC	PTPPSS	DEG_SCF_FBW7_1	756:761	Mutation rewiring degron network	0.25
p.S764Y	HT-115	large intestine	COSMIC	PPSSS	DEG_SPOP_SBC_1	758:762	Mutation rewiring degron network	0.2778
p.P16Q	SK-MEL-24	skin	COSMIC	VQSSS	DEG_SPOP_SBC_1	3:7	Mutation rewiring degron network	0.0833

Kaplan plot for TLK1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TLK1

UniProt ID: Q9UKI8

Entrez ID: 9874

Protein name: Serine/threonine-protein kinase tousled-like 1 (EC 2.7.11.1) (PKU-beta) (Tousled-like kinase 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TLK1 in