DegronMD

Uniprot ID: Q9UKI8

Source protein: Serine/threonine-protein kinase tousled-like 1

Source gene: TLK1

Class: DEG_APCC_DBOX_1

Location: 383:391

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6163

ASA_SCORE: 83.7222

COIL: 0.7726

CONS_SCORE: 0.4323

DSS_SCORE: 0.4455

HELIX: 0.1456

FCONS_SCORE: 0.9138

RIG_SCORE: 0.7747

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R384I	TCGA-21-1083	LUSC	TCGA	VRPNLPQLL	DEG_APCC_DBOX_1	0.8102
p.R384I	DO26769	LUSC	ICGC	VRPNLPQLL	DEG_APCC_DBOX_1	0.8102
p.H397D	TCGA-AX-A2IO	UCEC	TCGA	VRPNLPQLL	DEG_APCC_DBOX_1	0.1667
p.H397D	DO40800	UCEC	ICGC	VRPNLPQLL	DEG_APCC_DBOX_1	0.1667
p.E400G	TCGA-B5-A3FA	UCEC	TCGA	VRPNLPQLL	DEG_APCC_DBOX_1	0.0833
p.Q399H	TCGA-CR-7379	HNSC	TCGA	VRPNLPQLL	DEG_APCC_DBOX_1	0.1111
p.E400K	TCGA-EE-A2GC	SKCM	TCGA	VRPNLPQLL	DEG_APCC_DBOX_1	0.0833
p.E400K	DO37839	SKCM	ICGC	VRPNLPQLL	DEG_APCC_DBOX_1	0.0833
p.E400K	SIDM01068	Non-Small Cell Lung Carcinoma	GDSC	VRPNLPQLL	DEG_APCC_DBOX_1	0.0833
p.E400K	ACH-000562	Lung Cancer	CCLE	VRPNLPQLL	DEG_APCC_DBOX_1	0.0833
p.E400K	HCC-78	lung	COSMIC	VRPNLPQLL	DEG_APCC_DBOX_1	0.0833
p.E378Q	TCGA-GN-A8LK	SKCM	TCGA	VRPNLPQLL	DEG_APCC_DBOX_1	0.1944
p.E378Q	DO51259	SKCM	ICGC	VRPNLPQLL	DEG_APCC_DBOX_1	0.1944
p.L390V	TCGA-YL-A8SO	PRAD	TCGA	VRPNLPQLL	DEG_APCC_DBOX_1	0.5654
p.S382C	DO51884	BLCA	ICGC	VRPNLPQLL	DEG_APCC_DBOX_1	0.3056
p.Q389K	DO229015	LICA	ICGC	VRPNLPQLL	DEG_APCC_DBOX_1	0.5833
p.A373E	DO229036	LICA	ICGC	VRPNLPQLL	DEG_APCC_DBOX_1	0.0556
p.A373G	DO229058	LICA	ICGC	VRPNLPQLL	DEG_APCC_DBOX_1	0.0556
p.P387L	DO47795	STAD	ICGC	VRPNLPQLL	DEG_APCC_DBOX_1	0.7582
p.P388L	SIDM00364	B-Lymphoblastic Leukemia	GDSC	VRPNLPQLL	DEG_APCC_DBOX_1	0.6471
p.P388L	ACH-002059	Leukemia	CCLE	VRPNLPQLL	DEG_APCC_DBOX_1	0.6471
p.P388L	P30-OHK	haematopoietic_and_lymphoid_tissue	COSMIC	VRPNLPQLL	DEG_APCC_DBOX_1	0.6471
p.G376E	SIDM01779	Gastric Carcinoma	GDSC	VRPNLPQLL	DEG_APCC_DBOX_1	0.1389
p.G376E	ACH-000761	Gastric Cancer	CCLE	VRPNLPQLL	DEG_APCC_DBOX_1	0.1389
p.V374I	ACH-001346	Head and Neck Cancer	CCLE	VRPNLPQLL	DEG_APCC_DBOX_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UKI8	Serine/threonine-protein kinase tousled-like 1	DEG_APCC_DBOX_1	383:391	VRPNLPQLL	APC,CDC20,FZR1	0.6163	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VRPNLPQLL

Degron related mutations and impact score

Drug responses associated with TLK1 mutations

All proteins holding degron of VRPNLPQLL