DegronMD

Uniprot ID: Q9UKI8

Source protein: Serine/threonine-protein kinase tousled-like 1

Source gene: TLK1

Class: DEG_SCF_FBW7_1

Location: 756:761

E3 ligase: FBXW7

DEGRON score: 0.9859

ASA_SCORE: 86.4333

COIL: 0.9603

CONS_SCORE: 0.3258

DSS_SCORE: 0.5794

HELIX: 0.0183

FCONS_SCORE: 0.9574

RIG_SCORE: 0.6099

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G751R	TCGA-BR-4371	STAD	TCGA	PTPPSS	DEG_SCF_FBW7_1	0.1944
p.G751R	DO38348	STAD	ICGC	PTPPSS	DEG_SCF_FBW7_1	0.1944
p.L747P	TCGA-CG-4305	STAD	TCGA	PTPPSS	DEG_SCF_FBW7_1	0.0833
p.L747P	DO38823	STAD	ICGC	PTPPSS	DEG_SCF_FBW7_1	0.0833
p.S764Y	HT-115	large_intestine	COSMIC	PTPPSS	DEG_SCF_FBW7_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P40425	Pre-B-cell leukemia transcription factor 2	DEG_SCF_FBW7_1	335:340	PTPPSS	FBXW7	0.9228	More...
Q86VP3	Phosphofurin acidic cluster sorting protein 2	DEG_SCF_FBW7_1	721:726	PTPPSS	FBXW7	0.9883	More...
Q86WP2	Vasculin	DEG_SCF_FBW7_1	14:19	PTPPSS	FBXW7	0.9948	More...
Q8IWX8	Calcium homeostasis endoplasmic reticulum protein	DEG_SCF_FBW7_1	818:823	PTPPSS	FBXW7	0.9988	More...
Q9UKI8	Serine/threonine-protein kinase tousled-like 1	DEG_SCF_FBW7_1	756:761	PTPPSS	FBXW7	0.9859	More...
Q9UPS6	Histone-lysine N-methyltransferase SETD1B	DEG_SCF_FBW7_1	557:562	PTPPSS	FBXW7	0.8737	More...
Q6NV75	Probable G-protein coupled receptor 153	DEG_SCF_FBW7_1	538:543	PTPPSS	FBXW7	0.9703	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons