DegronMD

Uniprot ID: Q86VP3

Source protein: Phosphofurin acidic cluster sorting protein 2

Source gene: PACS2

Class: DEG_SCF_FBW7_1

Location: 721:726

E3 ligase: FBXW7

DEGRON score: 0.9883

ASA_SCORE: 85.2833

COIL: 0.9807

CONS_SCORE: 0.4675

DSS_SCORE: 0.6963

HELIX: 0.0078

FCONS_SCORE: 1.3345

RIG_SCORE: 0.493

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A712V	SIDM00569	Osteosarcoma	GDSC	PTPPSS	DEG_SCF_FBW7_1	0.0833
p.A712V	NY	bone	COSMIC	PTPPSS	DEG_SCF_FBW7_1	0.0833
p.T719M	SIDM00292	Small Cell Lung Carcinoma	GDSC	PTPPSS	DEG_SCF_FBW7_1	0.2778
p.T719M	LU-165	lung	COSMIC	PTPPSS	DEG_SCF_FBW7_1	0.2778
p.G731R	ACH-001509	Head and Neck Cancer	CCLE	PTPPSS	DEG_SCF_FBW7_1	0.1944
p.V729M	LU-165	lung	COSMIC	PTPPSS	DEG_SCF_FBW7_1	0.25
p.K736N	SNU-81	large_intestine	COSMIC	PTPPSS	DEG_SCF_FBW7_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P40425	Pre-B-cell leukemia transcription factor 2	DEG_SCF_FBW7_1	335:340	PTPPSS	FBXW7	0.9228	More...
Q86VP3	Phosphofurin acidic cluster sorting protein 2	DEG_SCF_FBW7_1	721:726	PTPPSS	FBXW7	0.9883	More...
Q86WP2	Vasculin	DEG_SCF_FBW7_1	14:19	PTPPSS	FBXW7	0.9948	More...
Q8IWX8	Calcium homeostasis endoplasmic reticulum protein	DEG_SCF_FBW7_1	818:823	PTPPSS	FBXW7	0.9988	More...
Q9UKI8	Serine/threonine-protein kinase tousled-like 1	DEG_SCF_FBW7_1	756:761	PTPPSS	FBXW7	0.9859	More...
Q9UPS6	Histone-lysine N-methyltransferase SETD1B	DEG_SCF_FBW7_1	557:562	PTPPSS	FBXW7	0.8737	More...
Q6NV75	Probable G-protein coupled receptor 153	DEG_SCF_FBW7_1	538:543	PTPPSS	FBXW7	0.9703	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons