DegronMD - Q8IWX8(CHERP)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P821A	TCGA-06-1802	GBM	TCGA	PTPPSS	DEG_SCF_FBW7_1	818:823	Mutation altering degron motif	0.6392
p.R811H	TCGA-2W-A8YY	CESC	TCGA	PTPPSS	DEG_SCF_FBW7_1	818:823	Mutation rewiring degron network	0.1389
p.A831E	TCGA-63-A5MM	LUSC	TCGA	PTPPSS	DEG_SCF_FBW7_1	818:823	Mutation rewiring degron network	0.1111
p.S815F	TCGA-BF-AAOX	SKCM	TCGA	PTPPSS	DEG_SCF_FBW7_1	818:823	Mutation blocking phosphorylation signal	0.6944
p.S830L	TCGA-BS-A0UF	UCEC	TCGA	PTPPSS	DEG_SCF_FBW7_1	818:823	Mutation blocking phosphorylation signal	0.5833
p.G827C	TCGA-EO-A3KX	UCEC	TCGA	PTPPSS	DEG_SCF_FBW7_1	818:823	Mutation rewiring degron network	0.2222
p.T830P	DO222404	BTCA	ICGC	PTPPSS	DEG_SCF_FBW7_1	818:823	Mutation blocking phosphorylation signal	0.5833
p.R812Q	DO219744	CESC	ICGC	PTPPSS	DEG_SCF_FBW7_1	818:823	Mutation rewiring degron network	0.1667
p.R812Q	SIDM00881	Breast Carcinoma	GDSC	PTPPSS	DEG_SCF_FBW7_1	818:823	Mutation rewiring degron network	0.1667
p.R812Q	SIDM00828	Other Sarcomas	GDSC	PTPPSS	DEG_SCF_FBW7_1	818:823	Mutation rewiring degron network	0.1667
p.R812Q	HT-1080	soft tissue	COSMIC	PTPPSS	DEG_SCF_FBW7_1	818:823	Mutation rewiring degron network	0.1667
p.R812Q	HCC1428	breast	COSMIC	PTPPSS	DEG_SCF_FBW7_1	818:823	Mutation rewiring degron network	0.1667
p.R822H	DO223732	CESC	ICGC	PTPPSS	DEG_SCF_FBW7_1	818:823	Mutation altering degron motif	0.8244
p.S811Y	DO10647	COAD	ICGC	PTPPSS	DEG_SCF_FBW7_1	818:823	Mutation rewiring degron network	0.1389
p.P818L	DO52065	HNSC	ICGC	PTPPSS	DEG_SCF_FBW7_1	818:823	Mutation altering degron motif	0.6471
p.R823W	DO232224	PBCA	ICGC	PTPPSS	DEG_SCF_FBW7_1	818:823	Mutation altering degron motif	0.8634
p.S817Y	DO38039	SKCM	ICGC	PTPPSS	DEG_SCF_FBW7_1	818:823	Mutation blocking phosphorylation signal	0.75
p.S826F	DO223907	SKCM	ICGC	PTPPSS	DEG_SCF_FBW7_1	818:823	Mutation rewiring degron network	0.25
p.R825L	DO229272	THCA	ICGC	PTPPSS	DEG_SCF_FBW7_1	818:823	Mutation rewiring degron network	0.2778
p.S809P	DO42568	UCEC	ICGC	PTPPSS	DEG_SCF_FBW7_1	818:823	Mutation rewiring degron network	0.0833
p.S823P	SIDM00442	Thyroid Gland Carcinoma	GDSC	PTPPSS	DEG_SCF_FBW7_1	818:823	Mutation altering degron motif	0.7863
p.S823P	ML-1	thyroid	COSMIC	PTPPSS	DEG_SCF_FBW7_1	818:823	Mutation altering degron motif	0.7863
p.R814W	SIDM00727	Non-Small Cell Lung Carcinoma	GDSC	PTPPSS	DEG_SCF_FBW7_1	818:823	Mutation rewiring degron network	0.2222
p.R814W	NCI-H2342	lung	COSMIC	PTPPSS	DEG_SCF_FBW7_1	818:823	Mutation rewiring degron network	0.2222
p.R825W	NCI-H2342	lung	COSMIC	PTPPSS	DEG_SCF_FBW7_1	818:823	Mutation rewiring degron network	0.2778
p.R823Q	HCC1428	breast	COSMIC	PTPPSS	DEG_SCF_FBW7_1	818:823	Mutation altering degron motif	0.7329
p.R823Q	HT-1080	soft tissue	COSMIC	PTPPSS	DEG_SCF_FBW7_1	818:823	Mutation altering degron motif	0.7329

Kaplan plot for CHERP in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CHERP

UniProt ID: Q8IWX8

Entrez ID: 10523

Protein name: Calcium homeostasis endoplasmic reticulum protein (ERPROT 213-21) (SR-related CTD-associated factor 6)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CHERP in