DegronMD

Uniprot ID: Q8IWX8

Source protein: Calcium homeostasis endoplasmic reticulum protein

Source gene: CHERP

Class: DEG_SCF_FBW7_1

Location: 818:823

E3 ligase: FBXW7

DEGRON score: 0.9988

ASA_SCORE: 85.5167

COIL: 0.9337

CONS_SCORE: 0.55

DSS_SCORE: 0.8343

HELIX: 0.0492

FCONS_SCORE: 1.5299

RIG_SCORE: 0.4631

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P821A	TCGA-06-1802	GBM	TCGA	PTPPSS	DEG_SCF_FBW7_1	0.6392
p.R811H	TCGA-2W-A8YY	CESC	TCGA	PTPPSS	DEG_SCF_FBW7_1	0.1389
p.A831E	TCGA-63-A5MM	LUSC	TCGA	PTPPSS	DEG_SCF_FBW7_1	0.1111
p.S815F	TCGA-BF-AAOX	SKCM	TCGA	PTPPSS	DEG_SCF_FBW7_1	0.6944
p.S830L	TCGA-BS-A0UF	UCEC	TCGA	PTPPSS	DEG_SCF_FBW7_1	0.5833
p.G827C	TCGA-EO-A3KX	UCEC	TCGA	PTPPSS	DEG_SCF_FBW7_1	0.2222
p.T830P	DO222404	BTCA	ICGC	PTPPSS	DEG_SCF_FBW7_1	0.5833
p.R812Q	DO219744	CESC	ICGC	PTPPSS	DEG_SCF_FBW7_1	0.1667
p.R812Q	SIDM00881	Breast Carcinoma	GDSC	PTPPSS	DEG_SCF_FBW7_1	0.1667
p.R812Q	SIDM00828	Other Sarcomas	GDSC	PTPPSS	DEG_SCF_FBW7_1	0.1667
p.R812Q	HT-1080	soft_tissue	COSMIC	PTPPSS	DEG_SCF_FBW7_1	0.1667
p.R812Q	HCC1428	breast	COSMIC	PTPPSS	DEG_SCF_FBW7_1	0.1667
p.R822H	DO223732	CESC	ICGC	PTPPSS	DEG_SCF_FBW7_1	0.8244
p.S811Y	DO10647	COAD	ICGC	PTPPSS	DEG_SCF_FBW7_1	0.1389
p.P818L	DO52065	HNSC	ICGC	PTPPSS	DEG_SCF_FBW7_1	0.6471
p.R823W	DO232224	PBCA	ICGC	PTPPSS	DEG_SCF_FBW7_1	0.8634
p.S817Y	DO38039	SKCM	ICGC	PTPPSS	DEG_SCF_FBW7_1	0.75
p.S826F	DO223907	SKCM	ICGC	PTPPSS	DEG_SCF_FBW7_1	0.25
p.R825L	DO229272	THCA	ICGC	PTPPSS	DEG_SCF_FBW7_1	0.2778
p.S809P	DO42568	UCEC	ICGC	PTPPSS	DEG_SCF_FBW7_1	0.0833
p.S823P	SIDM00442	Thyroid Gland Carcinoma	GDSC	PTPPSS	DEG_SCF_FBW7_1	0.7863
p.S823P	ML-1	thyroid	COSMIC	PTPPSS	DEG_SCF_FBW7_1	0.7863
p.R814W	SIDM00727	Non-Small Cell Lung Carcinoma	GDSC	PTPPSS	DEG_SCF_FBW7_1	0.2222
p.R814W	NCI-H2342	lung	COSMIC	PTPPSS	DEG_SCF_FBW7_1	0.2222
p.R825W	NCI-H2342	lung	COSMIC	PTPPSS	DEG_SCF_FBW7_1	0.2778
p.R823Q	HCC1428	breast	COSMIC	PTPPSS	DEG_SCF_FBW7_1	0.7329
p.R823Q	HT-1080	soft_tissue	COSMIC	PTPPSS	DEG_SCF_FBW7_1	0.7329

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P40425	Pre-B-cell leukemia transcription factor 2	DEG_SCF_FBW7_1	335:340	PTPPSS	FBXW7	0.9228	More...
Q86VP3	Phosphofurin acidic cluster sorting protein 2	DEG_SCF_FBW7_1	721:726	PTPPSS	FBXW7	0.9883	More...
Q86WP2	Vasculin	DEG_SCF_FBW7_1	14:19	PTPPSS	FBXW7	0.9948	More...
Q8IWX8	Calcium homeostasis endoplasmic reticulum protein	DEG_SCF_FBW7_1	818:823	PTPPSS	FBXW7	0.9988	More...
Q9UKI8	Serine/threonine-protein kinase tousled-like 1	DEG_SCF_FBW7_1	756:761	PTPPSS	FBXW7	0.9859	More...
Q9UPS6	Histone-lysine N-methyltransferase SETD1B	DEG_SCF_FBW7_1	557:562	PTPPSS	FBXW7	0.8737	More...
Q6NV75	Probable G-protein coupled receptor 153	DEG_SCF_FBW7_1	538:543	PTPPSS	FBXW7	0.9703	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PTPPSS

Degron related mutations and impact score

Drug responses associated with CHERP mutations

All proteins holding degron of PTPPSS