DegronMD

Uniprot ID: Q9UPS6

Source protein: Histone-lysine N-methyltransferase SETD1B

Source gene: SETD1B

Class: DEG_SCF_FBW7_1

Location: 557:562

E3 ligase: FBXW7

DEGRON score: 0.8737

ASA_SCORE: 90.5333

COIL: 0.9738

CONS_SCORE: 0.2864

DSS_SCORE: 0.8556

HELIX: 0.0123

FCONS_SCORE: 1.0177

RIG_SCORE: 0.488

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R555Q	TCGA-AP-A1DK	UCEC	TCGA	PTPPSS	DEG_SCF_FBW7_1	0.2778
p.R555Q	DO42033	UCEC	ICGC	PTPPSS	DEG_SCF_FBW7_1	0.2778
p.I572V	DO23188	LINC	ICGC	PTPPSS	DEG_SCF_FBW7_1	0.0556
p.I572V	ACH-000831	Endometrial/Uterine Cancer	CCLE	PTPPSS	DEG_SCF_FBW7_1	0.0556
p.S550F	ACH-000931	Skin Cancer	CCLE	PTPPSS	DEG_SCF_FBW7_1	0.1389
p.R563H	ACH-000986	Colon/Colorectal Cancer	CCLE	PTPPSS	DEG_SCF_FBW7_1	0.3056
p.R563H	ACH-000990	Endometrial/Uterine Cancer	CCLE	PTPPSS	DEG_SCF_FBW7_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P40425	Pre-B-cell leukemia transcription factor 2	DEG_SCF_FBW7_1	335:340	PTPPSS	FBXW7	0.9228	More...
Q86VP3	Phosphofurin acidic cluster sorting protein 2	DEG_SCF_FBW7_1	721:726	PTPPSS	FBXW7	0.9883	More...
Q86WP2	Vasculin	DEG_SCF_FBW7_1	14:19	PTPPSS	FBXW7	0.9948	More...
Q8IWX8	Calcium homeostasis endoplasmic reticulum protein	DEG_SCF_FBW7_1	818:823	PTPPSS	FBXW7	0.9988	More...
Q9UKI8	Serine/threonine-protein kinase tousled-like 1	DEG_SCF_FBW7_1	756:761	PTPPSS	FBXW7	0.9859	More...
Q9UPS6	Histone-lysine N-methyltransferase SETD1B	DEG_SCF_FBW7_1	557:562	PTPPSS	FBXW7	0.8737	More...
Q6NV75	Probable G-protein coupled receptor 153	DEG_SCF_FBW7_1	538:543	PTPPSS	FBXW7	0.9703	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons