DegronMD

Uniprot ID: P40425

Source protein: Pre-B-cell leukemia transcription factor 2

Source gene: PBX2

Class: DEG_SCF_FBW7_1

Location: 335:340

E3 ligase: FBXW7

DEGRON score: 0.9228

ASA_SCORE: 89.7667

COIL: 0.95

CONS_SCORE: 0.3219

DSS_SCORE: 0.6898

HELIX: 0.0272

FCONS_SCORE: 1.1003

RIG_SCORE: 0.5498

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S340C	TCGA-4Z-AA7W	BLCA	TCGA	PTPPSS	DEG_SCF_FBW7_1	0.7541
p.S340C	DO218984	BLCA	ICGC	PTPPSS	DEG_SCF_FBW7_1	0.7541
p.N348D	TCGA-AP-A1DR	UCEC	TCGA	PTPPSS	DEG_SCF_FBW7_1	0.1111
p.N348D	DO43747	UCEC	ICGC	PTPPSS	DEG_SCF_FBW7_1	0.1111
p.S330N	TCGA-B0-5096	KIRC	TCGA	PTPPSS	DEG_SCF_FBW7_1	0.6389
p.S330N	DO19218	KIRC	ICGC	PTPPSS	DEG_SCF_FBW7_1	0.6389
p.P335T	TCGA-CD-A4MI	STAD	TCGA	PTPPSS	DEG_SCF_FBW7_1	0.7031
p.P335T	DO47717	STAD	ICGC	PTPPSS	DEG_SCF_FBW7_1	0.7031
p.P338R	TCGA-NH-A6GC	COAD	TCGA	PTPPSS	DEG_SCF_FBW7_1	0.6401
p.P338R	DO50093	COAD	ICGC	PTPPSS	DEG_SCF_FBW7_1	0.6401
p.A341V	DO229275	THCA	ICGC	PTPPSS	DEG_SCF_FBW7_1	0.3056
p.T325S	SIDM01608	Endometrial Carcinoma	GDSC	PTPPSS	DEG_SCF_FBW7_1	0.5
p.T325S	ACH-000990	Endometrial/Uterine Cancer	CCLE	PTPPSS	DEG_SCF_FBW7_1	0.5

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P40425	Pre-B-cell leukemia transcription factor 2	DEG_SCF_FBW7_1	335:340	PTPPSS	FBXW7	0.9228	More...
Q86VP3	Phosphofurin acidic cluster sorting protein 2	DEG_SCF_FBW7_1	721:726	PTPPSS	FBXW7	0.9883	More...
Q86WP2	Vasculin	DEG_SCF_FBW7_1	14:19	PTPPSS	FBXW7	0.9948	More...
Q8IWX8	Calcium homeostasis endoplasmic reticulum protein	DEG_SCF_FBW7_1	818:823	PTPPSS	FBXW7	0.9988	More...
Q9UKI8	Serine/threonine-protein kinase tousled-like 1	DEG_SCF_FBW7_1	756:761	PTPPSS	FBXW7	0.9859	More...
Q9UPS6	Histone-lysine N-methyltransferase SETD1B	DEG_SCF_FBW7_1	557:562	PTPPSS	FBXW7	0.8737	More...
Q6NV75	Probable G-protein coupled receptor 153	DEG_SCF_FBW7_1	538:543	PTPPSS	FBXW7	0.9703	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons