DegronMD - Q86WP2(GPBP1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.N239S	TCGA-95-7039	LUAD	TCGA	TKENK	DEG_APCC_KENBOX_2	229:233	Mutation rewiring degron network	0.1667
p.N239S	DO228949	LICA	ICGC	TKENK	DEG_APCC_KENBOX_2	229:233	Mutation rewiring degron network	0.1667
p.N239S	DO23907	LUAD	ICGC	TKENK	DEG_APCC_KENBOX_2	229:233	Mutation rewiring degron network	0.1667
p.R375Q	TCGA-B5-A0JY	UCEC	TCGA	VLSSS	DEG_SPOP_SBC_1	377:381	Mutation rewiring degron network	0.2778
p.R375Q	DO43041	UCEC	ICGC	VLSSS	DEG_SPOP_SBC_1	377:381	Mutation rewiring degron network	0.2778
p.T243I	TCGA-BR-8369	STAD	TCGA	TKENK	DEG_APCC_KENBOX_2	229:233	Mutation rewiring degron network	0.0556
p.T243I	DO47889	STAD	ICGC	TKENK	DEG_APCC_KENBOX_2	229:233	Mutation rewiring degron network	0.0556
p.P222S	TCGA-D5-6929	COAD	TCGA	TKENK	DEG_APCC_KENBOX_2	229:233	Mutation rewiring degron network	0.1389
p.P222S	DO7870	COAD	ICGC	TKENK	DEG_APCC_KENBOX_2	229:233	Mutation rewiring degron network	0.1389
p.P16L	TCGA-FI-A2EW	UCEC	TCGA	PTPPSS	DEG_SCF_FBW7_1	14:19	Mutation altering degron motif	0.7582
p.P16L	TCGA-FI-A2EW	UCEC	TCGA	PPSST	DEG_SPOP_SBC_1	16:20	Mutation altering degron motif	0.7582
p.P16L	DO41500	UCEC	ICGC	PTPPSS	DEG_SCF_FBW7_1	14:19	Mutation altering degron motif	0.7582
p.P16L	DO41500	UCEC	ICGC	PPSST	DEG_SPOP_SBC_1	16:20	Mutation altering degron motif	0.7582
p.T15N	DO233732	GACA	ICGC	PTPPSS	DEG_SCF_FBW7_1	14:19	Mutation altering degron motif	0.8166
p.D383Y	DO229029	LICA	ICGC	VLSSS	DEG_SPOP_SBC_1	377:381	Mutation rewiring degron network	0.2778
p.P229L	DO33432	PACA	ICGC	TKENK	DEG_APCC_KENBOX_2	229:233	Mutation altering degron motif	0.7582
p.E369D	DO222392	STAD	ICGC	VLSSS	DEG_SPOP_SBC_1	377:381	Mutation rewiring degron network	0.1111
p.K220N	DO43306	UCEC	ICGC	TKENK	DEG_APCC_KENBOX_2	229:233	Mutation rewiring degron network	0.0833
p.Q13H	DO41361	UCEC	ICGC	PTPPSS	DEG_SCF_FBW7_1	14:19	Mutation rewiring degron network	0.3056
p.Q13H	DO41361	UCEC	ICGC	PPSST	DEG_SPOP_SBC_1	16:20	Mutation rewiring degron network	0.25
p.T20A	SIDM00582	Pancreatic Carcinoma	GDSC	PPSST	DEG_SPOP_SBC_1	16:20	Mutation altering degron motif	0.7139
p.T20A	ACH-000281	Pancreatic Cancer	CCLE	PPSST	DEG_SPOP_SBC_1	16:20	Mutation altering degron motif	0.7139
p.T20A	KP-2	pancreas	COSMIC	PPSST	DEG_SPOP_SBC_1	16:20	Mutation altering degron motif	0.7139
p.T243A	SIDM00336	Melanoma	GDSC	TKENK	DEG_APCC_KENBOX_2	229:233	Mutation rewiring degron network	0.0556
p.T243A	SIDM01233	Colorectal Carcinoma	GDSC	TKENK	DEG_APCC_KENBOX_2	229:233	Mutation rewiring degron network	0.0556
p.T243A	SIDM01164	Glioma	GDSC	TKENK	DEG_APCC_KENBOX_2	229:233	Mutation rewiring degron network	0.0556
p.T243A	SIDM00665	Gastric Carcinoma	GDSC	TKENK	DEG_APCC_KENBOX_2	229:233	Mutation rewiring degron network	0.0556
p.T243A	SIDM01228	Melanoma	GDSC	TKENK	DEG_APCC_KENBOX_2	229:233	Mutation rewiring degron network	0.0556
p.T243A	SIDM01564	Colorectal Carcinoma	GDSC	TKENK	DEG_APCC_KENBOX_2	229:233	Mutation rewiring degron network	0.0556
p.A9T	SIDM00373	Endometrial Carcinoma	GDSC	PTPPSS	DEG_SCF_FBW7_1	14:19	Mutation rewiring degron network	0.1944
p.A9T	SIDM00373	Endometrial Carcinoma	GDSC	PPSST	DEG_SPOP_SBC_1	16:20	Mutation rewiring degron network	0.1389
p.A9T	ACH-000974	Endometrial/Uterine Cancer	CCLE	PTPPSS	DEG_SCF_FBW7_1	14:19	Mutation rewiring degron network	0.1944
p.A9T	ACH-000974	Endometrial/Uterine Cancer	CCLE	PPSST	DEG_SPOP_SBC_1	16:20	Mutation rewiring degron network	0.1389
p.A9T	SNG-M	endometrium	COSMIC	PTPPSS	DEG_SCF_FBW7_1	14:19	Mutation rewiring degron network	0.1944
p.A9T	SNG-M	endometrium	COSMIC	PPSST	DEG_SPOP_SBC_1	16:20	Mutation rewiring degron network	0.1389
p.L24S	SIDM00780	Colorectal Carcinoma	GDSC	PTPPSS	DEG_SCF_FBW7_1	14:19	Mutation rewiring degron network	0.1944
p.L24S	SIDM00780	Colorectal Carcinoma	GDSC	PPSST	DEG_SPOP_SBC_1	16:20	Mutation rewiring degron network	0.2222
p.A237V	SIDM01519	Head and Neck Carcinoma	GDSC	TKENK	DEG_APCC_KENBOX_2	229:233	Mutation rewiring degron network	0.2222
p.A224V	ACH-000992	Head and Neck Cancer	CCLE	TKENK	DEG_APCC_KENBOX_2	229:233	Mutation rewiring degron network	0.1944
p.P24L	697	haematopoietic and lymphoid tissue	COSMIC	PTPPSS	DEG_SCF_FBW7_1	14:19	Mutation rewiring degron network	0.1944
p.P24L	697	haematopoietic and lymphoid tissue	COSMIC	PPSST	DEG_SPOP_SBC_1	16:20	Mutation rewiring degron network	0.2222
p.S227N	LB2241-RCC	kidney	COSMIC	TKENK	DEG_APCC_KENBOX_2	229:233	Mutation rewiring degron network	0.2778
p.D11N	A172	central nervous system	COSMIC	PTPPSS	DEG_SCF_FBW7_1	14:19	Mutation rewiring degron network	0.25
p.D11N	A172	central nervous system	COSMIC	PPSST	DEG_SPOP_SBC_1	16:20	Mutation rewiring degron network	0.1944
p.S390N	LB2241-RCC	kidney	COSMIC	VLSSS	DEG_SPOP_SBC_1	377:381	Mutation substituting flanking lysine	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

GPBP1

UniProt ID: Q86WP2

Entrez ID: 65056

Protein name: Vasculin (GC-rich promoter-binding protein 1) (Vascular wall-linked protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for GPBP1 in