DegronMD

Uniprot ID: Q86WP2

Source protein: Vasculin

Source gene: GPBP1

Class: DEG_APCC_KENBOX_2

Location: 229:233

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9819

ASA_SCORE: 106.52

COIL: 0.8146

CONS_SCORE: 0.5117

DSS_SCORE: 0.6361

HELIX: 0.141

FCONS_SCORE: 1.0435

RIG_SCORE: 0.7038

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N239S	TCGA-95-7039	LUAD	TCGA	TKENK	DEG_APCC_KENBOX_2	0.1667
p.N239S	DO228949	LICA	ICGC	TKENK	DEG_APCC_KENBOX_2	0.1667
p.N239S	DO23907	LUAD	ICGC	TKENK	DEG_APCC_KENBOX_2	0.1667
p.T243I	TCGA-BR-8369	STAD	TCGA	TKENK	DEG_APCC_KENBOX_2	0.0556
p.T243I	DO47889	STAD	ICGC	TKENK	DEG_APCC_KENBOX_2	0.0556
p.P222S	TCGA-D5-6929	COAD	TCGA	TKENK	DEG_APCC_KENBOX_2	0.1389
p.P222S	DO7870	COAD	ICGC	TKENK	DEG_APCC_KENBOX_2	0.1389
p.P229L	DO33432	PACA	ICGC	TKENK	DEG_APCC_KENBOX_2	0.7582
p.K220N	DO43306	UCEC	ICGC	TKENK	DEG_APCC_KENBOX_2	0.0833
p.T243A	SIDM00336	Melanoma	GDSC	TKENK	DEG_APCC_KENBOX_2	0.0556
p.T243A	SIDM01233	Colorectal Carcinoma	GDSC	TKENK	DEG_APCC_KENBOX_2	0.0556
p.T243A	SIDM01164	Glioma	GDSC	TKENK	DEG_APCC_KENBOX_2	0.0556
p.T243A	SIDM00665	Gastric Carcinoma	GDSC	TKENK	DEG_APCC_KENBOX_2	0.0556
p.T243A	SIDM01228	Melanoma	GDSC	TKENK	DEG_APCC_KENBOX_2	0.0556
p.T243A	SIDM01564	Colorectal Carcinoma	GDSC	TKENK	DEG_APCC_KENBOX_2	0.0556
p.A237V	SIDM01519	Head and Neck Carcinoma	GDSC	TKENK	DEG_APCC_KENBOX_2	0.2222
p.A224V	ACH-000992	Head and Neck Cancer	CCLE	TKENK	DEG_APCC_KENBOX_2	0.1944
p.S227N	LB2241-RCC	kidney	COSMIC	TKENK	DEG_APCC_KENBOX_2	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons