DegronMD - Q8N6M0(OTUD6B)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K64N	TCGA-AP-A0LM	UCEC	TCGA	HREELEQLK	DEG_APCC_DBOX_1	63:71	Mutation altering degron motif	0.6918
p.K64N	TCGA-AX-A0J0	UCEC	TCGA	HREELEQLK	DEG_APCC_DBOX_1	63:71	Mutation altering degron motif	0.6918
p.K64N	DO43306	UCEC	ICGC	HREELEQLK	DEG_APCC_DBOX_1	63:71	Mutation altering degron motif	0.6918
p.K64N	DO41133	UCEC	ICGC	HREELEQLK	DEG_APCC_DBOX_1	63:71	Mutation altering degron motif	0.6918
p.K59N	TCGA-BA-A4IG	HNSC	TCGA	HREELEQLK	DEG_APCC_DBOX_1	63:71	Mutation rewiring degron network	0.2222
p.K59N	DO52028	HNSC	ICGC	HREELEQLK	DEG_APCC_DBOX_1	63:71	Mutation rewiring degron network	0.2222
p.K87T	TCGA-BP-5168	KIRC	TCGA	TKENK	DEG_APCC_KENBOX_2	74:78	Mutation rewiring degron network	0.0833
p.K87T	DO18671	KIRC	ICGC	TKENK	DEG_APCC_KENBOX_2	74:78	Mutation rewiring degron network	0.0833
p.K64E	TCGA-BR-8368	STAD	TCGA	HREELEQLK	DEG_APCC_DBOX_1	63:71	Mutation altering degron motif	0.7022
p.K64E	DO47981	STAD	ICGC	HREELEQLK	DEG_APCC_DBOX_1	63:71	Mutation altering degron motif	0.7022
p.A83V	TCGA-CN-5369	HNSC	TCGA	TKENK	DEG_APCC_KENBOX_2	74:78	Mutation rewiring degron network	0.1944
p.A83V	DO16069	HNSC	ICGC	TKENK	DEG_APCC_KENBOX_2	74:78	Mutation rewiring degron network	0.1944
p.V82M	DO48388	BLCA	ICGC	TKENK	DEG_APCC_KENBOX_2	74:78	Mutation rewiring degron network	0.2222
p.L78R	DO50759	LICA	ICGC	TKENK	DEG_APCC_KENBOX_2	74:78	Mutation altering degron motif	0.8428
p.P68A	SIDM00768	Non-Small Cell Lung Carcinoma	GDSC	HREELEQLK	DEG_APCC_DBOX_1	63:71	Mutation altering degron motif	0.7503
p.P68A	ACH-000894	Lung Cancer	CCLE	HREELEQLK	DEG_APCC_DBOX_1	63:71	Mutation altering degron motif	0.7503
p.P68A	NCI-H1869	lung	COSMIC	HREELEQLK	DEG_APCC_DBOX_1	63:71	Mutation altering degron motif	0.7503
p.L56S	SIDM01088	Endometrial Carcinoma	GDSC	HREELEQLK	DEG_APCC_DBOX_1	63:71	Mutation rewiring degron network	0.1389
p.L56S	ACH-000965	Endometrial/Uterine Cancer	CCLE	HREELEQLK	DEG_APCC_DBOX_1	63:71	Mutation rewiring degron network	0.1389
p.L56S	RL95-2	endometrium	COSMIC	HREELEQLK	DEG_APCC_DBOX_1	63:71	Mutation rewiring degron network	0.1389
p.E63K	NCI-H187	lung	COSMIC	HREELEQLK	DEG_APCC_DBOX_1	63:71	Mutation altering degron motif	0.7022

Kaplan plot for OTUD6B in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

OTUD6B

UniProt ID: Q8N6M0

Entrez ID: 51633

Protein name: Deubiquitinase OTUD6B (EC 3.4.19.12) (DUBA-5) (OTU domain-containing protein 6B)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for OTUD6B in