DegronMD

Uniprot ID: Q8N6M0

Source protein: Deubiquitinase OTUD6B

Source gene: OTUD6B

Class: DEG_APCC_KENBOX_2

Location: 74:78

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7864

ASA_SCORE: 116.86

COIL: 0.7246

CONS_SCORE: 0.4392

DSS_SCORE: 0.3341

HELIX: 0.2568

FCONS_SCORE: 0.9798

RIG_SCORE: 0.7556

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K87T	TCGA-BP-5168	KIRC	TCGA	TKENK	DEG_APCC_KENBOX_2	0.0833
p.K87T	DO18671	KIRC	ICGC	TKENK	DEG_APCC_KENBOX_2	0.0833
p.A83V	TCGA-CN-5369	HNSC	TCGA	TKENK	DEG_APCC_KENBOX_2	0.1944
p.A83V	DO16069	HNSC	ICGC	TKENK	DEG_APCC_KENBOX_2	0.1944
p.V82M	DO48388	BLCA	ICGC	TKENK	DEG_APCC_KENBOX_2	0.2222
p.L78R	DO50759	LICA	ICGC	TKENK	DEG_APCC_KENBOX_2	0.8428

DegronMD: protein-targeted degradation, mutation and drug response to degrons