DegronMD

Uniprot ID: Q8N6M0

Source protein: Deubiquitinase OTUD6B

Source gene: OTUD6B

Class: DEG_APCC_DBOX_1

Location: 63:71

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5291

ASA_SCORE: 101.4

COIL: 0.181

CONS_SCORE: 0.5274

DSS_SCORE: 0.4809

HELIX: 0.8156

FCONS_SCORE: 1.0346

RIG_SCORE: 0.7802

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K64N	TCGA-AP-A0LM	UCEC	TCGA	HREELEQLK	DEG_APCC_DBOX_1	0.6918
p.K64N	TCGA-AX-A0J0	UCEC	TCGA	HREELEQLK	DEG_APCC_DBOX_1	0.6918
p.K64N	DO43306	UCEC	ICGC	HREELEQLK	DEG_APCC_DBOX_1	0.6918
p.K64N	DO41133	UCEC	ICGC	HREELEQLK	DEG_APCC_DBOX_1	0.6918
p.K59N	TCGA-BA-A4IG	HNSC	TCGA	HREELEQLK	DEG_APCC_DBOX_1	0.2222
p.K59N	DO52028	HNSC	ICGC	HREELEQLK	DEG_APCC_DBOX_1	0.2222
p.K64E	TCGA-BR-8368	STAD	TCGA	HREELEQLK	DEG_APCC_DBOX_1	0.7022
p.K64E	DO47981	STAD	ICGC	HREELEQLK	DEG_APCC_DBOX_1	0.7022
p.P68A	SIDM00768	Non-Small Cell Lung Carcinoma	GDSC	HREELEQLK	DEG_APCC_DBOX_1	0.7503
p.P68A	ACH-000894	Lung Cancer	CCLE	HREELEQLK	DEG_APCC_DBOX_1	0.7503
p.P68A	NCI-H1869	lung	COSMIC	HREELEQLK	DEG_APCC_DBOX_1	0.7503
p.L56S	SIDM01088	Endometrial Carcinoma	GDSC	HREELEQLK	DEG_APCC_DBOX_1	0.1389
p.L56S	ACH-000965	Endometrial/Uterine Cancer	CCLE	HREELEQLK	DEG_APCC_DBOX_1	0.1389
p.L56S	RL95-2	endometrium	COSMIC	HREELEQLK	DEG_APCC_DBOX_1	0.1389
p.E63K	NCI-H187	lung	COSMIC	HREELEQLK	DEG_APCC_DBOX_1	0.7022

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N6M0	Deubiquitinase OTUD6B	DEG_APCC_DBOX_1	63:71	HREELEQLK	APC,CDC20,FZR1	0.5291	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons