DegronMD

Uniprot ID: Q86WP2

Source protein: Vasculin

Source gene: GPBP1

Class: DEG_SCF_FBW7_1

Location: 14:19

E3 ligase: FBXW7

DEGRON score: 0.9948

ASA_SCORE: 74.55

COIL: 0.9485

CONS_SCORE: 0.5546

DSS_SCORE: 0.4298

HELIX: 0.03

FCONS_SCORE: 0.9495

RIG_SCORE: 0.6461

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P16L	TCGA-FI-A2EW	UCEC	TCGA	PTPPSS	DEG_SCF_FBW7_1	0.7582
p.P16L	DO41500	UCEC	ICGC	PTPPSS	DEG_SCF_FBW7_1	0.7582
p.T15N	DO233732	GACA	ICGC	PTPPSS	DEG_SCF_FBW7_1	0.8166
p.Q13H	DO41361	UCEC	ICGC	PTPPSS	DEG_SCF_FBW7_1	0.3056
p.A9T	SIDM00373	Endometrial Carcinoma	GDSC	PTPPSS	DEG_SCF_FBW7_1	0.1944
p.A9T	ACH-000974	Endometrial/Uterine Cancer	CCLE	PTPPSS	DEG_SCF_FBW7_1	0.1944
p.A9T	SNG-M	endometrium	COSMIC	PTPPSS	DEG_SCF_FBW7_1	0.1944
p.L24S	SIDM00780	Colorectal Carcinoma	GDSC	PTPPSS	DEG_SCF_FBW7_1	0.1944
p.P24L	697	haematopoietic_and_lymphoid_tissue	COSMIC	PTPPSS	DEG_SCF_FBW7_1	0.1944
p.D11N	A172	central_nervous_system	COSMIC	PTPPSS	DEG_SCF_FBW7_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P40425	Pre-B-cell leukemia transcription factor 2	DEG_SCF_FBW7_1	335:340	PTPPSS	FBXW7	0.9228	More...
Q86VP3	Phosphofurin acidic cluster sorting protein 2	DEG_SCF_FBW7_1	721:726	PTPPSS	FBXW7	0.9883	More...
Q86WP2	Vasculin	DEG_SCF_FBW7_1	14:19	PTPPSS	FBXW7	0.9948	More...
Q8IWX8	Calcium homeostasis endoplasmic reticulum protein	DEG_SCF_FBW7_1	818:823	PTPPSS	FBXW7	0.9988	More...
Q9UKI8	Serine/threonine-protein kinase tousled-like 1	DEG_SCF_FBW7_1	756:761	PTPPSS	FBXW7	0.9859	More...
Q9UPS6	Histone-lysine N-methyltransferase SETD1B	DEG_SCF_FBW7_1	557:562	PTPPSS	FBXW7	0.8737	More...
Q6NV75	Probable G-protein coupled receptor 153	DEG_SCF_FBW7_1	538:543	PTPPSS	FBXW7	0.9703	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons