DegronMD - P40425(PBX2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S159W	TCGA-23-2641	OV	TCGA	DYR	CBL_MET	160:162	Mutation blocking phosphorylation signal	0.75
p.S159W	DO31574	OV	ICGC	DYR	CBL_MET	160:162	Mutation blocking phosphorylation signal	0.75
p.S340C	TCGA-4Z-AA7W	BLCA	TCGA	PTPPSS	DEG_SCF_FBW7_1	335:340	Mutation altering degron motif	0.7541
p.S340C	DO218984	BLCA	ICGC	PTPPSS	DEG_SCF_FBW7_1	335:340	Mutation altering degron motif	0.7541
p.N348D	TCGA-AP-A1DR	UCEC	TCGA	PTPPSS	DEG_SCF_FBW7_1	335:340	Mutation rewiring degron network	0.1111
p.N348D	DO43747	UCEC	ICGC	PTPPSS	DEG_SCF_FBW7_1	335:340	Mutation rewiring degron network	0.1111
p.D153G	TCGA-AX-A2HD	UCEC	TCGA	DYR	CBL_MET	160:162	Mutation rewiring degron network	0.1389
p.D153G	DO42608	UCEC	ICGC	DYR	CBL_MET	160:162	Mutation rewiring degron network	0.1389
p.S330N	TCGA-B0-5096	KIRC	TCGA	PTPPSS	DEG_SCF_FBW7_1	335:340	Mutation blocking phosphorylation signal	0.6389
p.S330N	DO19218	KIRC	ICGC	PTPPSS	DEG_SCF_FBW7_1	335:340	Mutation blocking phosphorylation signal	0.6389
p.G14A	TCGA-BJ-A0Z2	THCA	TCGA	GRGGLGLVS	DEG_APCC_DBOX_1	14:22	Mutation altering degron motif	0.6429
p.G14A	DO229234	THCA	ICGC	GRGGLGLVS	DEG_APCC_DBOX_1	14:22	Mutation altering degron motif	0.6429
p.G14A	DO39306	THCA	ICGC	GRGGLGLVS	DEG_APCC_DBOX_1	14:22	Mutation altering degron motif	0.6429
p.G14A	MM1S	haematopoietic and lymphoid tissue	COSMIC	GRGGLGLVS	DEG_APCC_DBOX_1	14:22	Mutation altering degron motif	0.6429
p.G14A	NCI-H1437	lung	COSMIC	GRGGLGLVS	DEG_APCC_DBOX_1	14:22	Mutation altering degron motif	0.6429
p.G14A	DU-145	prostate	COSMIC	GRGGLGLVS	DEG_APCC_DBOX_1	14:22	Mutation altering degron motif	0.6429
p.G14A	MOLT-16	haematopoietic and lymphoid tissue	COSMIC	GRGGLGLVS	DEG_APCC_DBOX_1	14:22	Mutation altering degron motif	0.6429
p.L165R	TCGA-BR-6458	STAD	TCGA	DYR	CBL_MET	160:162	Mutation rewiring degron network	0.25
p.L165R	DO38296	STAD	ICGC	DYR	CBL_MET	160:162	Mutation rewiring degron network	0.25
p.P335T	TCGA-CD-A4MI	STAD	TCGA	PTPPSS	DEG_SCF_FBW7_1	335:340	Mutation altering degron motif	0.7031
p.P335T	DO47717	STAD	ICGC	PTPPSS	DEG_SCF_FBW7_1	335:340	Mutation altering degron motif	0.7031
p.G19A	TCGA-CN-A63U	HNSC	TCGA	GRGGLGLVS	DEG_APCC_DBOX_1	14:22	Mutation altering degron motif	0.6429
p.G19A	DO44454	HNSC	ICGC	GRGGLGLVS	DEG_APCC_DBOX_1	14:22	Mutation altering degron motif	0.6429
p.P338R	TCGA-NH-A6GC	COAD	TCGA	PTPPSS	DEG_SCF_FBW7_1	335:340	Mutation altering degron motif	0.6401
p.P338R	DO50093	COAD	ICGC	PTPPSS	DEG_SCF_FBW7_1	335:340	Mutation altering degron motif	0.6401
p.S163I	DO233270	GACA	ICGC	DYR	CBL_MET	160:162	Mutation rewiring degron network	0.3056
p.R169H	DO228338	MALY	ICGC	DYR	CBL_MET	160:162	Mutation rewiring degron network	0.1389
p.R169H	SIDM00948	Burkitt's Lymphoma	GDSC	DYR	CBL_MET	160:162	Mutation rewiring degron network	0.1389
p.R169H	ACH-002232	Lymphoma	CCLE	DYR	CBL_MET	160:162	Mutation rewiring degron network	0.1389
p.R169H	DG-75	haematopoietic and lymphoid tissue	COSMIC	DYR	CBL_MET	160:162	Mutation rewiring degron network	0.1389
p.E24G	DO229479	SKCA	ICGC	GRGGLGLVS	DEG_APCC_DBOX_1	14:22	Mutation rewiring degron network	0.2778
p.A341V	DO229275	THCA	ICGC	PTPPSS	DEG_SCF_FBW7_1	335:340	Mutation rewiring degron network	0.3056
p.Y161D	SIDM00193	Colorectal Carcinoma	GDSC	DYR	CBL_MET	160:162	Mutation altering degron motif	0.7325
p.Y161D	ACH-000991	Colon/Colorectal Cancer	CCLE	DYR	CBL_MET	160:162	Mutation altering degron motif	0.7325
p.Y161D	SNU-81	large intestine	COSMIC	DYR	CBL_MET	160:162	Mutation altering degron motif	0.7325
p.T325S	SIDM01608	Endometrial Carcinoma	GDSC	PTPPSS	DEG_SCF_FBW7_1	335:340	Mutation blocking phosphorylation signal	0.5
p.T325S	ACH-000990	Endometrial/Uterine Cancer	CCLE	PTPPSS	DEG_SCF_FBW7_1	335:340	Mutation blocking phosphorylation signal	0.5
p.L18Q	SIDM01573	Plasma Cell Myeloma	GDSC	GRGGLGLVS	DEG_APCC_DBOX_1	14:22	Mutation altering degron motif	0.7765
p.L18Q	ACH-000576	Myeloma	CCLE	GRGGLGLVS	DEG_APCC_DBOX_1	14:22	Mutation altering degron motif	0.7765
p.I171V	SIDM01518	Oral Cavity Carcinoma	GDSC	DYR	CBL_MET	160:162	Mutation rewiring degron network	0.0833
p.I171V	ACH-000771	Head and Neck Cancer	CCLE	DYR	CBL_MET	160:162	Mutation rewiring degron network	0.0833
p.P32S	ACH-001688	Kidney Cancer	CCLE	GRGGLGLVS	DEG_APCC_DBOX_1	14:22	Mutation rewiring degron network	0.0556

Kaplan plot for PBX2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PBX2

UniProt ID: P40425

Entrez ID: 5089

Protein name: Pre-B-cell leukemia transcription factor 2 (Homeobox protein PBX2) (Protein G17)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PBX2 in