DegronMD

Uniprot ID: P40425

Source protein: Pre-B-cell leukemia transcription factor 2

Source gene: PBX2

Class: DEG_APCC_DBOX_1

Location: 14:22

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8936

ASA_SCORE: 61.4222

COIL: 0.7978

CONS_SCORE: 0.3682

DSS_SCORE: 0.8312

HELIX: 0.0489

FCONS_SCORE: 0.9701

RIG_SCORE: 0.5504

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L18Q	SIDM01573	Plasma Cell Myeloma	GDSC	GRGGLGLVS	DEG_APCC_DBOX_1	0.7765
p.L18Q	ACH-000576	Myeloma	CCLE	GRGGLGLVS	DEG_APCC_DBOX_1	0.7765
p.G14A	TCGA-BJ-A0Z2	THCA	TCGA	GRGGLGLVS	DEG_APCC_DBOX_1	0.6429
p.G14A	DO229234	THCA	ICGC	GRGGLGLVS	DEG_APCC_DBOX_1	0.6429
p.G14A	DO39306	THCA	ICGC	GRGGLGLVS	DEG_APCC_DBOX_1	0.6429
p.G14A	MM1S	haematopoietic_and_lymphoid_tissue	COSMIC	GRGGLGLVS	DEG_APCC_DBOX_1	0.6429
p.G14A	NCI-H1437	lung	COSMIC	GRGGLGLVS	DEG_APCC_DBOX_1	0.6429
p.G14A	DU-145	prostate	COSMIC	GRGGLGLVS	DEG_APCC_DBOX_1	0.6429
p.G14A	MOLT-16	haematopoietic_and_lymphoid_tissue	COSMIC	GRGGLGLVS	DEG_APCC_DBOX_1	0.6429
p.G19A	TCGA-CN-A63U	HNSC	TCGA	GRGGLGLVS	DEG_APCC_DBOX_1	0.6429
p.G19A	DO44454	HNSC	ICGC	GRGGLGLVS	DEG_APCC_DBOX_1	0.6429
p.E24G	DO229479	SKCA	ICGC	GRGGLGLVS	DEG_APCC_DBOX_1	0.2778
p.P32S	ACH-001688	Kidney Cancer	CCLE	GRGGLGLVS	DEG_APCC_DBOX_1	0.0556

Showing 1 to 13 of 13 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P40425	Pre-B-cell leukemia transcription factor 2	DEG_APCC_DBOX_1	14:22	GRGGLGLVS	APC,CDC20,FZR1	0.8936	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons