DegronMD: protein-targeted degradation, mutation and drug response to degrons
Home
(current)
Browse
Proteins/Degrons
Mutations
Drug response
Network-rewiring
Drug resistance
Search
Tutorial
Download
Contact
Links
BSML
CPH
CGC
Degron:
PTPPSS
Uniprot ID:
Q6NV75
Source protein:
Probable G-protein coupled receptor 153
Source gene:
GPR153
Class:
DEG_SCF_FBW7_1
Location:
538:543
E3 ligase:
FBXW7
DEGRON score:
0.9703
ASA_SCORE:
69.4833
COIL:
0.9078
CONS_SCORE:
0.3944
DSS_SCORE:
0.9
HELIX:
0.0667
FCONS_SCORE:
1.0445
RIG_SCORE:
0.4989
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.G535R
DO222623
BTCA
ICGC
PTPPSS
DEG_SCF_FBW7_1
0.25
p.P552S
SIDM00875
Breast Carcinoma
GDSC
PTPPSS
DEG_SCF_FBW7_1
0.0833
p.P552S
SIDM00257
Neuroblastoma
GDSC
PTPPSS
DEG_SCF_FBW7_1
0.0833
p.E536A
ACH-000612
Lymphoma
CCLE
PTPPSS
DEG_SCF_FBW7_1
0.2778
Drug responses associated with GPR153 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PTPPSS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P40425
Pre-B-cell leukemia transcription factor 2
DEG_SCF_FBW7_1
335:340
PTPPSS
FBXW7
0.9228
More...
Q86VP3
Phosphofurin acidic cluster sorting protein 2
DEG_SCF_FBW7_1
721:726
PTPPSS
FBXW7
0.9883
More...
Q86WP2
Vasculin
DEG_SCF_FBW7_1
14:19
PTPPSS
FBXW7
0.9948
More...
Q8IWX8
Calcium homeostasis endoplasmic reticulum protein
DEG_SCF_FBW7_1
818:823
PTPPSS
FBXW7
0.9988
More...
Q9UKI8
Serine/threonine-protein kinase tousled-like 1
DEG_SCF_FBW7_1
756:761
PTPPSS
FBXW7
0.9859
More...
Q9UPS6
Histone-lysine N-methyltransferase SETD1B
DEG_SCF_FBW7_1
557:562
PTPPSS
FBXW7
0.8737
More...
Q6NV75
Probable G-protein coupled receptor 153
DEG_SCF_FBW7_1
538:543
PTPPSS
FBXW7
0.9703
More...