DegronMD - Q86VP3(PACS2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S61F	TCGA-21-1079	LUSC	TCGA	LVVFKE	LIG_APCC_ABBA_1	49:54	Mutation rewiring degron network	0.1389
p.S61F	TCGA-21-1079	LUSC	TCGA	KLVVFKE	LIG_APCC_ABBAyCdc20_2	48:54	Mutation rewiring degron network	0.1389
p.S61F	TCGA-D3-A2JD	SKCM	TCGA	LVVFKE	LIG_APCC_ABBA_1	49:54	Mutation rewiring degron network	0.1389
p.S61F	TCGA-D3-A2JD	SKCM	TCGA	KLVVFKE	LIG_APCC_ABBAyCdc20_2	48:54	Mutation rewiring degron network	0.1389
p.S61F	DO26846	LUSC	ICGC	LVVFKE	LIG_APCC_ABBA_1	49:54	Mutation rewiring degron network	0.1389
p.S61F	DO26846	LUSC	ICGC	KLVVFKE	LIG_APCC_ABBAyCdc20_2	48:54	Mutation rewiring degron network	0.1389
p.S61F	DO37543	SKCM	ICGC	LVVFKE	LIG_APCC_ABBA_1	49:54	Mutation rewiring degron network	0.1389
p.S61F	DO37543	SKCM	ICGC	KLVVFKE	LIG_APCC_ABBAyCdc20_2	48:54	Mutation rewiring degron network	0.1389
p.S238L	TCGA-90-A4ED	LUSC	TCGA	VRTTS	DEG_SPOP_SBC_1	240:244	Mutation blocking phosphorylation signal	0.7222
p.S238L	TCGA-D3-A8GM	SKCM	TCGA	VRTTS	DEG_SPOP_SBC_1	240:244	Mutation blocking phosphorylation signal	0.7222
p.S238L	TCGA-EO-A3B0	UCEC	TCGA	VRTTS	DEG_SPOP_SBC_1	240:244	Mutation blocking phosphorylation signal	0.7222
p.R237I	TCGA-AX-A2HC	UCEC	TCGA	VRTTS	DEG_SPOP_SBC_1	240:244	Mutation rewiring degron network	0.25
p.D309N	TCGA-B5-A0JY	UCEC	TCGA	LRPYFE	LIG_APCC_ABBA_1	319:324	Mutation rewiring degron network	0.0556
p.P317R	TCGA-BP-5168	KIRC	TCGA	LRPYFE	LIG_APCC_ABBA_1	319:324	Mutation rewiring degron network	0.2778
p.V311I	TCGA-BR-8078	STAD	TCGA	LRPYFE	LIG_APCC_ABBA_1	319:324	Mutation rewiring degron network	0.1111
p.R320L	TCGA-DZ-6133	KIRP	TCGA	LRPYFE	LIG_APCC_ABBA_1	319:324	Mutation altering degron motif	0.7316
p.T242M	TCGA-EO-A3B0	UCEC	TCGA	VRTTS	DEG_SPOP_SBC_1	240:244	Mutation altering degron motif	0.7423
p.T242M	TCGA-EY-A549	UCEC	TCGA	VRTTS	DEG_SPOP_SBC_1	240:244	Mutation altering degron motif	0.7423
p.T246I	TCGA-FI-A2D0	UCEC	TCGA	VRTTS	DEG_SPOP_SBC_1	240:244	Mutation blocking phosphorylation signal	0.7222
p.N250Y	TCGA-FP-8099	STAD	TCGA	VRTTS	DEG_SPOP_SBC_1	240:244	Mutation rewiring degron network	0.1667
p.R236W	TCGA-VQ-A8P2	STAD	TCGA	VRTTS	DEG_SPOP_SBC_1	240:244	Mutation rewiring degron network	0.2222
p.E253K	DO51865	BLCA	ICGC	VRTTS	DEG_SPOP_SBC_1	240:244	Mutation rewiring degron network	0.0833
p.S241L	DO1555	BRCA	ICGC	VRTTS	DEG_SPOP_SBC_1	240:244	Mutation altering degron motif	0.7667
p.G245E	DO2401	BRCA	ICGC	VRTTS	DEG_SPOP_SBC_1	240:244	Mutation rewiring degron network	0.3056
p.E325K	DO48978	CESC	ICGC	LRPYFE	LIG_APCC_ABBA_1	319:324	Mutation rewiring degron network	0.3056
p.V63M	DO223703	COAD	ICGC	LVVFKE	LIG_APCC_ABBA_1	49:54	Mutation rewiring degron network	0.0833
p.V63M	DO223703	COAD	ICGC	KLVVFKE	LIG_APCC_ABBAyCdc20_2	48:54	Mutation rewiring degron network	0.0833
p.V318M	DO227563	COCA	ICGC	LRPYFE	LIG_APCC_ABBA_1	319:324	Mutation rewiring degron network	0.3056
p.V318M	DO232761	PBCA	ICGC	LRPYFE	LIG_APCC_ABBA_1	319:324	Mutation rewiring degron network	0.3056
p.V234M	DO234377	ESAD	ICGC	VRTTS	DEG_SPOP_SBC_1	240:244	Mutation substituting flanking lysine	0.2778
p.T45P	DO218031	GACA	ICGC	LVVFKE	LIG_APCC_ABBA_1	49:54	Mutation rewiring degron network	0.2222
p.T45P	DO218031	GACA	ICGC	KLVVFKE	LIG_APCC_ABBAyCdc20_2	48:54	Mutation rewiring degron network	0.25
p.T45P	DO218243	GACA	ICGC	LVVFKE	LIG_APCC_ABBA_1	49:54	Mutation rewiring degron network	0.2222
p.T45P	DO218243	GACA	ICGC	KLVVFKE	LIG_APCC_ABBAyCdc20_2	48:54	Mutation rewiring degron network	0.25
p.K315T	DO233814	GACA	ICGC	LRPYFE	LIG_APCC_ABBA_1	319:324	Mutation rewiring degron network	0.2222
p.H248Y	DO19663	KIRC	ICGC	VRTTS	DEG_SPOP_SBC_1	240:244	Mutation rewiring degron network	0.2222
p.H248Y	CAL-62	thyroid	COSMIC	VRTTS	DEG_SPOP_SBC_1	240:244	Mutation rewiring degron network	0.2222
p.A233S	DO228976	LICA	ICGC	VRTTS	DEG_SPOP_SBC_1	240:244	Mutation substituting flanking lysine	0.25
p.A230S	DO228976	LICA	ICGC	VRTTS	DEG_SPOP_SBC_1	240:244	Mutation rewiring degron network	0.0556
p.Q252H	DO229026	LICA	ICGC	VRTTS	DEG_SPOP_SBC_1	240:244	Mutation substituting flanking lysine	0.2222
p.Q58H	DO229037	LICA	ICGC	LVVFKE	LIG_APCC_ABBA_1	49:54	Mutation rewiring degron network	0.2222
p.Q58H	DO229037	LICA	ICGC	KLVVFKE	LIG_APCC_ABBAyCdc20_2	48:54	Mutation rewiring degron network	0.2222
p.A321S	DO229045	LICA	ICGC	LRPYFE	LIG_APCC_ABBA_1	319:324	Mutation altering degron motif	0.7588
p.G245R	DO22986	LIHC	ICGC	VRTTS	DEG_SPOP_SBC_1	240:244	Mutation rewiring degron network	0.3056
p.L44M	DO23464	LINC	ICGC	LVVFKE	LIG_APCC_ABBA_1	49:54	Mutation rewiring degron network	0.1944
p.L44M	DO23464	LINC	ICGC	KLVVFKE	LIG_APCC_ABBAyCdc20_2	48:54	Mutation rewiring degron network	0.2222
p.C51Y	DO229177	LMS	ICGC	LVVFKE	LIG_APCC_ABBA_1	49:54	Mutation altering degron motif	0.7087
p.C51Y	DO229177	LMS	ICGC	KLVVFKE	LIG_APCC_ABBAyCdc20_2	48:54	Mutation altering degron motif	0.7087
p.D61Y	DO23631	LUAD	ICGC	LVVFKE	LIG_APCC_ABBA_1	49:54	Mutation rewiring degron network	0.1389
p.D61Y	DO23631	LUAD	ICGC	KLVVFKE	LIG_APCC_ABBAyCdc20_2	48:54	Mutation rewiring degron network	0.1389
p.S249F	DO222434	MELA	ICGC	VRTTS	DEG_SPOP_SBC_1	240:244	Mutation rewiring degron network	0.1944
p.P42S	DO222670	MELA	ICGC	LVVFKE	LIG_APCC_ABBA_1	49:54	Mutation rewiring degron network	0.1389
p.P42S	DO222670	MELA	ICGC	KLVVFKE	LIG_APCC_ABBAyCdc20_2	48:54	Mutation rewiring degron network	0.1667
p.F232V	DO50083	OV	ICGC	VRTTS	DEG_SPOP_SBC_1	240:244	Mutation rewiring degron network	0.1111
p.A311T	DO29940	OV	ICGC	LRPYFE	LIG_APCC_ABBA_1	319:324	Mutation rewiring degron network	0.1111
p.E322K	DO220056	SARC	ICGC	LRPYFE	LIG_APCC_ABBA_1	319:324	Mutation altering degron motif	0.7022
p.R328W	DO220258	SARC	ICGC	LRPYFE	LIG_APCC_ABBA_1	319:324	Mutation rewiring degron network	0.2222
p.S249P	DO218878	SKCA	ICGC	VRTTS	DEG_SPOP_SBC_1	240:244	Mutation rewiring degron network	0.1944
p.P320R	DO37414	SKCM	ICGC	LRPYFE	LIG_APCC_ABBA_1	319:324	Mutation altering degron motif	0.7512
p.P250S	DO37406	SKCM	ICGC	VRTTS	DEG_SPOP_SBC_1	240:244	Mutation rewiring degron network	0.1667
p.P320L	DO37936	SKCM	ICGC	LRPYFE	LIG_APCC_ABBA_1	319:324	Mutation altering degron motif	0.7582
p.P324S	DO229221	THCA	ICGC	LRPYFE	LIG_APCC_ABBA_1	319:324	Mutation altering degron motif	0.6752
p.K332N	DO223286	UCEC	ICGC	LRPYFE	LIG_APCC_ABBA_1	319:324	Mutation rewiring degron network	0.1111
p.R230Q	DO41999	UCEC	ICGC	VRTTS	DEG_SPOP_SBC_1	240:244	Mutation rewiring degron network	0.0556
p.G325C	SIDM02021	Esophageal Carcinoma	GDSC	LRPYFE	LIG_APCC_ABBA_1	319:324	Mutation rewiring degron network	0.3056
p.S327W	SIDM00661	B-Cell Non-Hodgkin's Lymphoma	GDSC	LRPYFE	LIG_APCC_ABBA_1	319:324	Mutation rewiring degron network	0.25
p.S327W	ACH-000914	Lymphoma	CCLE	LRPYFE	LIG_APCC_ABBA_1	319:324	Mutation rewiring degron network	0.25
p.S327W	HT	haematopoietic and lymphoid tissue	COSMIC	LRPYFE	LIG_APCC_ABBA_1	319:324	Mutation rewiring degron network	0.25
p.A712V	SIDM00569	Osteosarcoma	GDSC	PTPPSS	DEG_SCF_FBW7_1	721:726	Mutation rewiring degron network	0.0833
p.A712V	NY	bone	COSMIC	PTPPSS	DEG_SCF_FBW7_1	721:726	Mutation rewiring degron network	0.0833
p.T719M	SIDM00292	Small Cell Lung Carcinoma	GDSC	PTPPSS	DEG_SCF_FBW7_1	721:726	Mutation rewiring degron network	0.2778
p.T719M	LU-165	lung	COSMIC	PTPPSS	DEG_SCF_FBW7_1	721:726	Mutation rewiring degron network	0.2778
p.E58Q	SIDM01700	Hodgkin's Lymphoma	GDSC	LVVFKE	LIG_APCC_ABBA_1	49:54	Mutation rewiring degron network	0.2222
p.E58Q	SIDM01700	Hodgkin's Lymphoma	GDSC	KLVVFKE	LIG_APCC_ABBAyCdc20_2	48:54	Mutation rewiring degron network	0.2222
p.T314P	ACH-000922	Leukemia	CCLE	LRPYFE	LIG_APCC_ABBA_1	319:324	Mutation rewiring degron network	0.1944
p.G731R	ACH-001509	Head and Neck Cancer	CCLE	PTPPSS	DEG_SCF_FBW7_1	721:726	Mutation rewiring degron network	0.1944
p.L312H	ACH-001513	Cervical Cancer	CCLE	LRPYFE	LIG_APCC_ABBA_1	319:324	Mutation rewiring degron network	0.1389
p.P250L	IGR-1	skin	COSMIC	VRTTS	DEG_SPOP_SBC_1	240:244	Mutation rewiring degron network	0.1667
p.K43N	SJRH30	soft tissue	COSMIC	LVVFKE	LIG_APCC_ABBA_1	49:54	Mutation blocking phosphorylation signal	0.6111
p.K43N	SJRH30	soft tissue	COSMIC	KLVVFKE	LIG_APCC_ABBAyCdc20_2	48:54	Mutation blocking phosphorylation signal	0.6389
p.V729M	LU-165	lung	COSMIC	PTPPSS	DEG_SCF_FBW7_1	721:726	Mutation rewiring degron network	0.25
p.E319K	BT-474	breast	COSMIC	LRPYFE	LIG_APCC_ABBA_1	319:324	Mutation altering degron motif	0.7022
p.K736N	SNU-81	large intestine	COSMIC	PTPPSS	DEG_SCF_FBW7_1	721:726	Mutation rewiring degron network	0.0556
p.K315N	MFE-319	endometrium	COSMIC	LRPYFE	LIG_APCC_ABBA_1	319:324	Mutation rewiring degron network	0.2222
p.D236E	SUP-B8	haematopoietic and lymphoid tissue	COSMIC	VRTTS	DEG_SPOP_SBC_1	240:244	Mutation rewiring degron network	0.2222
p.D236E	NCI-H2066	lung	COSMIC	VRTTS	DEG_SPOP_SBC_1	240:244	Mutation rewiring degron network	0.2222
p.Q243K	KARPAS-620	haematopoietic and lymphoid tissue	COSMIC	VRTTS	DEG_SPOP_SBC_1	240:244	Mutation altering degron motif	0.6944
p.S252W	HT	haematopoietic and lymphoid tissue	COSMIC	VRTTS	DEG_SPOP_SBC_1	240:244	Mutation substituting flanking lysine	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PACS2

UniProt ID: Q86VP3

Entrez ID: 23241

Protein name: Phosphofurin acidic cluster sorting protein 2 (PACS-2) (PACS1-like protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PACS2 in