DegronMD

Uniprot ID: Q86VP3

Source protein: Phosphofurin acidic cluster sorting protein 2

Source gene: PACS2

Class: LIG_APCC_ABBA_1

Location: 319:324

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9847

ASA_SCORE: 89.1833

COIL: 0.7897

CONS_SCORE: 0.653

DSS_SCORE: 0.6136

HELIX: 0.1043

FCONS_SCORE: 1.294

RIG_SCORE: 0.6925

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D309N	TCGA-B5-A0JY	UCEC	TCGA	LRPYFE	LIG_APCC_ABBA_1	0.0556
p.P317R	TCGA-BP-5168	KIRC	TCGA	LRPYFE	LIG_APCC_ABBA_1	0.2778
p.V311I	TCGA-BR-8078	STAD	TCGA	LRPYFE	LIG_APCC_ABBA_1	0.1111
p.R320L	TCGA-DZ-6133	KIRP	TCGA	LRPYFE	LIG_APCC_ABBA_1	0.7316
p.E325K	DO48978	CESC	ICGC	LRPYFE	LIG_APCC_ABBA_1	0.3056
p.V318M	DO227563	COCA	ICGC	LRPYFE	LIG_APCC_ABBA_1	0.3056
p.V318M	DO232761	PBCA	ICGC	LRPYFE	LIG_APCC_ABBA_1	0.3056
p.K315T	DO233814	GACA	ICGC	LRPYFE	LIG_APCC_ABBA_1	0.2222
p.A321S	DO229045	LICA	ICGC	LRPYFE	LIG_APCC_ABBA_1	0.7588
p.A311T	DO29940	OV	ICGC	LRPYFE	LIG_APCC_ABBA_1	0.1111
p.E322K	DO220056	SARC	ICGC	LRPYFE	LIG_APCC_ABBA_1	0.7022
p.R328W	DO220258	SARC	ICGC	LRPYFE	LIG_APCC_ABBA_1	0.2222
p.P320R	DO37414	SKCM	ICGC	LRPYFE	LIG_APCC_ABBA_1	0.7512
p.P320L	DO37936	SKCM	ICGC	LRPYFE	LIG_APCC_ABBA_1	0.7582
p.P324S	DO229221	THCA	ICGC	LRPYFE	LIG_APCC_ABBA_1	0.6752
p.K332N	DO223286	UCEC	ICGC	LRPYFE	LIG_APCC_ABBA_1	0.1111
p.G325C	SIDM02021	Esophageal Carcinoma	GDSC	LRPYFE	LIG_APCC_ABBA_1	0.3056
p.S327W	SIDM00661	B-Cell Non-Hodgkin's Lymphoma	GDSC	LRPYFE	LIG_APCC_ABBA_1	0.25
p.S327W	ACH-000914	Lymphoma	CCLE	LRPYFE	LIG_APCC_ABBA_1	0.25
p.S327W	HT	haematopoietic_and_lymphoid_tissue	COSMIC	LRPYFE	LIG_APCC_ABBA_1	0.25
p.T314P	ACH-000922	Leukemia	CCLE	LRPYFE	LIG_APCC_ABBA_1	0.1944
p.L312H	ACH-001513	Cervical Cancer	CCLE	LRPYFE	LIG_APCC_ABBA_1	0.1389
p.E319K	BT-474	breast	COSMIC	LRPYFE	LIG_APCC_ABBA_1	0.7022
p.K315N	MFE-319	endometrium	COSMIC	LRPYFE	LIG_APCC_ABBA_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86VP3	Phosphofurin acidic cluster sorting protein 2	LIG_APCC_ABBA_1	319:324	LRPYFE	APC,CDC20,FZR1	0.9847	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons