DegronMD

Uniprot ID: Q86VP3

Source protein: Phosphofurin acidic cluster sorting protein 2

Source gene: PACS2

Class: LIG_APCC_ABBA_1

Location: 49:54

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8414

ASA_SCORE: 49.35

COIL: 0.1907

CONS_SCORE: 0.4913

DSS_SCORE: 0.013

HELIX: 0.0063

FCONS_SCORE: 0.8636

RIG_SCORE: 0.9653

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S61F	TCGA-21-1079	LUSC	TCGA	LVVFKE	LIG_APCC_ABBA_1	0.1389
p.S61F	TCGA-D3-A2JD	SKCM	TCGA	LVVFKE	LIG_APCC_ABBA_1	0.1389
p.S61F	DO26846	LUSC	ICGC	LVVFKE	LIG_APCC_ABBA_1	0.1389
p.S61F	DO37543	SKCM	ICGC	LVVFKE	LIG_APCC_ABBA_1	0.1389
p.V63M	DO223703	COAD	ICGC	LVVFKE	LIG_APCC_ABBA_1	0.0833
p.T45P	DO218031	GACA	ICGC	LVVFKE	LIG_APCC_ABBA_1	0.2222
p.T45P	DO218243	GACA	ICGC	LVVFKE	LIG_APCC_ABBA_1	0.2222
p.Q58H	DO229037	LICA	ICGC	LVVFKE	LIG_APCC_ABBA_1	0.2222
p.L44M	DO23464	LINC	ICGC	LVVFKE	LIG_APCC_ABBA_1	0.1944
p.C51Y	DO229177	LMS	ICGC	LVVFKE	LIG_APCC_ABBA_1	0.7087
p.D61Y	DO23631	LUAD	ICGC	LVVFKE	LIG_APCC_ABBA_1	0.1389
p.P42S	DO222670	MELA	ICGC	LVVFKE	LIG_APCC_ABBA_1	0.1389
p.E58Q	SIDM01700	Hodgkin's Lymphoma	GDSC	LVVFKE	LIG_APCC_ABBA_1	0.2222
p.K43N	SJRH30	soft_tissue	COSMIC	LVVFKE	LIG_APCC_ABBA_1	0.6111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86VP3	Phosphofurin acidic cluster sorting protein 2	LIG_APCC_ABBA_1	49:54	LVVFKE	APC,CDC20,FZR1	0.8414	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons