DegronMD

Uniprot ID: Q86VP3

Source protein: Phosphofurin acidic cluster sorting protein 2

Source gene: PACS2

Class: LIG_APCC_ABBAyCdc20_2

Location: 48:54

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8053

ASA_SCORE: 53.0857

COIL: 0.1676

CONS_SCORE: 0.4939

DSS_SCORE: 0.0151

HELIX: 0.006

FCONS_SCORE: 0.8577

RIG_SCORE: 0.9638

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S61F	TCGA-21-1079	LUSC	TCGA	KLVVFKE	LIG_APCC_ABBAyCdc20_2	0.1389
p.S61F	TCGA-D3-A2JD	SKCM	TCGA	KLVVFKE	LIG_APCC_ABBAyCdc20_2	0.1389
p.S61F	DO26846	LUSC	ICGC	KLVVFKE	LIG_APCC_ABBAyCdc20_2	0.1389
p.S61F	DO37543	SKCM	ICGC	KLVVFKE	LIG_APCC_ABBAyCdc20_2	0.1389
p.V63M	DO223703	COAD	ICGC	KLVVFKE	LIG_APCC_ABBAyCdc20_2	0.0833
p.T45P	DO218031	GACA	ICGC	KLVVFKE	LIG_APCC_ABBAyCdc20_2	0.25
p.T45P	DO218243	GACA	ICGC	KLVVFKE	LIG_APCC_ABBAyCdc20_2	0.25
p.Q58H	DO229037	LICA	ICGC	KLVVFKE	LIG_APCC_ABBAyCdc20_2	0.2222
p.L44M	DO23464	LINC	ICGC	KLVVFKE	LIG_APCC_ABBAyCdc20_2	0.2222
p.C51Y	DO229177	LMS	ICGC	KLVVFKE	LIG_APCC_ABBAyCdc20_2	0.7087
p.D61Y	DO23631	LUAD	ICGC	KLVVFKE	LIG_APCC_ABBAyCdc20_2	0.1389
p.P42S	DO222670	MELA	ICGC	KLVVFKE	LIG_APCC_ABBAyCdc20_2	0.1667
p.E58Q	SIDM01700	Hodgkin's Lymphoma	GDSC	KLVVFKE	LIG_APCC_ABBAyCdc20_2	0.2222
p.K43N	SJRH30	soft_tissue	COSMIC	KLVVFKE	LIG_APCC_ABBAyCdc20_2	0.6389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86VP3	Phosphofurin acidic cluster sorting protein 2	LIG_APCC_ABBAyCdc20_2	48:54	KLVVFKE	APC,CDC20,FZR1	0.8053	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons